Coupling between Cbz-Arg-OH and Leu-X Catalyzed by Trypsin and Papain

Trypsin [EC 3.4.21.4] and papain [EC 3.4.22.2] catalyzed the coupling between Cbz-Arg-OH and Leu-X (X=−NH2, -OEt, -OBut, or ) in solution. The optimum pH for synthesis by trypsin and by papain was 6.5-7.0 and 5.5, respectively. Papain possessed reactivity several times higher than that of trypsin. T...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 1980-01, Vol.88 (3), p.669-675
Hauptverfasser:	TSUZUKI, Hiroshige, OKA, Tatsushi, MORIHARA, Kazuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine - analogs & derivatives Dimethylformamide Dipeptides - chemical synthesis Hydrogen-Ion Concentration Leucine - analogs & derivatives Papain Trypsin
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