Pharmacokinetics of atenolol in hypertensive subjects with and without co-administration of chlorthalidone
The pharmacokinetics of atenolol with and without the co-administration of chlorthalidone were studied in five hypertensive subjects. Concomitant administration of chlorthalidone appears to have little if any effect on the pharmacokinetics of atenolol during treatment for 7 days. The atenolol elimin...
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| Veröffentlicht in: | European journal of clinical pharmacology 1980-05, Vol.17 (5), p.333-337 |
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| container_end_page | 337 |
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| container_issue | 5 |
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| container_title | European journal of clinical pharmacology |
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| creator | Riva, E Farina, P L Sega, R Tognoni, G Bastain, W McAinsh, J |
| description | The pharmacokinetics of atenolol with and without the co-administration of chlorthalidone were studied in five hypertensive subjects. Concomitant administration of chlorthalidone appears to have little if any effect on the pharmacokinetics of atenolol during treatment for 7 days. The atenolol elimination half-lives were 6.7 +/- 1.1 and 6.3 +/- 0.9 h, respectively, with and without chlorthalidone. Two healthy volunteers also received a single 50 mg oral dose of chlorthalidone. Their blood profiles and pharmacokinetics were similar to those observed in hypertensive subjects, but a statistically significant difference (p < 0.01) was found between the urinary excretion half-lives of chlorthalidone. This difference may be because chronic administration of the drug caused saturation of red cell binding. |
| doi_str_mv | 10.1007/BF00558445 |
| format | Article |
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Concomitant administration of chlorthalidone appears to have little if any effect on the pharmacokinetics of atenolol during treatment for 7 days. The atenolol elimination half-lives were 6.7 +/- 1.1 and 6.3 +/- 0.9 h, respectively, with and without chlorthalidone. Two healthy volunteers also received a single 50 mg oral dose of chlorthalidone. Their blood profiles and pharmacokinetics were similar to those observed in hypertensive subjects, but a statistically significant difference (p < 0.01) was found between the urinary excretion half-lives of chlorthalidone. This difference may be because chronic administration of the drug caused saturation of red cell binding.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF00558445</identifier><identifier>PMID: 7418712</identifier><language>eng</language><publisher>Germany</publisher><subject>Adult ; Atenolol - administration & dosage ; Atenolol - metabolism ; Chlorthalidone - administration & dosage ; Chlorthalidone - metabolism ; Drug Therapy, Combination ; Half-Life ; Humans ; Hypertension - blood ; Hypertension - drug therapy ; Hypertension - urine ; Male ; Propanolamines - metabolism</subject><ispartof>European journal of clinical pharmacology, 1980-05, Vol.17 (5), p.333-337</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-9b79ef07a062c03b258e47d7e635acdb46574966e63537212de069c80ed947903</citedby><cites>FETCH-LOGICAL-c282t-9b79ef07a062c03b258e47d7e635acdb46574966e63537212de069c80ed947903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7418712$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Riva, E</creatorcontrib><creatorcontrib>Farina, P L</creatorcontrib><creatorcontrib>Sega, R</creatorcontrib><creatorcontrib>Tognoni, G</creatorcontrib><creatorcontrib>Bastain, W</creatorcontrib><creatorcontrib>McAinsh, J</creatorcontrib><title>Pharmacokinetics of atenolol in hypertensive subjects with and without co-administration of chlorthalidone</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>The pharmacokinetics of atenolol with and without the co-administration of chlorthalidone were studied in five hypertensive subjects. Concomitant administration of chlorthalidone appears to have little if any effect on the pharmacokinetics of atenolol during treatment for 7 days. The atenolol elimination half-lives were 6.7 +/- 1.1 and 6.3 +/- 0.9 h, respectively, with and without chlorthalidone. Two healthy volunteers also received a single 50 mg oral dose of chlorthalidone. Their blood profiles and pharmacokinetics were similar to those observed in hypertensive subjects, but a statistically significant difference (p < 0.01) was found between the urinary excretion half-lives of chlorthalidone. This difference may be because chronic administration of the drug caused saturation of red cell binding.</description><subject>Adult</subject><subject>Atenolol - administration & dosage</subject><subject>Atenolol - metabolism</subject><subject>Chlorthalidone - administration & dosage</subject><subject>Chlorthalidone - metabolism</subject><subject>Drug Therapy, Combination</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - urine</subject><subject>Male</subject><subject>Propanolamines - metabolism</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFLwzAUxoMoc04v3oWcPAjVlzRp2qMOp8JAD3ouafpGM9tmJqmy_95Oh57e98GPH7yPkHMG1wxA3dwtAKTMhZAHZMpEyhMGgh2SKUDKkqxQcExOQlgDMFlAOiETJViuGJ-S9UujfaeNe7c9RmsCdSuqI_audS21PW22G_RjD_YTaRiqNZoY6JeNDdV9_RPcEKlxia4729sQvY7W9TuPaVrnY6NbW7seT8nRSrcBz_Z3Rt4W96_zx2T5_PA0v10mhuc8JkWlClyB0pBxA2nFZY5C1QqzVGpTVyKTShRZtuup4ozXCFlhcsC6EGp8b0Yuf70b7z4GDLHsbDDYtrpHN4RSSa64lGoEr35B410IHlflxttO-23JoNwNW_4PO8IXe-tQdVj_ofsl02-2enQb</recordid><startdate>198005</startdate><enddate>198005</enddate><creator>Riva, E</creator><creator>Farina, P L</creator><creator>Sega, R</creator><creator>Tognoni, G</creator><creator>Bastain, W</creator><creator>McAinsh, J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198005</creationdate><title>Pharmacokinetics of atenolol in hypertensive subjects with and without co-administration of chlorthalidone</title><author>Riva, E ; Farina, P L ; Sega, R ; Tognoni, G ; Bastain, W ; McAinsh, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-9b79ef07a062c03b258e47d7e635acdb46574966e63537212de069c80ed947903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Adult</topic><topic>Atenolol - administration & dosage</topic><topic>Atenolol - metabolism</topic><topic>Chlorthalidone - administration & dosage</topic><topic>Chlorthalidone - metabolism</topic><topic>Drug Therapy, Combination</topic><topic>Half-Life</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - urine</topic><topic>Male</topic><topic>Propanolamines - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Riva, E</creatorcontrib><creatorcontrib>Farina, P L</creatorcontrib><creatorcontrib>Sega, R</creatorcontrib><creatorcontrib>Tognoni, G</creatorcontrib><creatorcontrib>Bastain, W</creatorcontrib><creatorcontrib>McAinsh, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Riva, E</au><au>Farina, P L</au><au>Sega, R</au><au>Tognoni, G</au><au>Bastain, W</au><au>McAinsh, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of atenolol in hypertensive subjects with and without co-administration of chlorthalidone</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1980-05</date><risdate>1980</risdate><volume>17</volume><issue>5</issue><spage>333</spage><epage>337</epage><pages>333-337</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>The pharmacokinetics of atenolol with and without the co-administration of chlorthalidone were studied in five hypertensive subjects. 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| identifier | ISSN: 0031-6970 |
| ispartof | European journal of clinical pharmacology, 1980-05, Vol.17 (5), p.333-337 |
| issn | 0031-6970 1432-1041 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Atenolol - administration & dosage Atenolol - metabolism Chlorthalidone - administration & dosage Chlorthalidone - metabolism Drug Therapy, Combination Half-Life Humans Hypertension - blood Hypertension - drug therapy Hypertension - urine Male Propanolamines - metabolism |
| title | Pharmacokinetics of atenolol in hypertensive subjects with and without co-administration of chlorthalidone |
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