Ultrastructural evidence of microvascular damage and myocardial cell injury after coronary artery occlusion: which comes first?
Both microvascular damage and myocardial cell injury occur after coronary occlusion, but the relationship of these two events is unclear; specifically, it is unknown whether microvascular damage causes myocardial cell injury. Dogs were subjected to coronary occlusion for 20, 40, 60, 90 or 180 minute...
Gespeichert in:
| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1980-11, Vol.62 (5), p.945-952 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 952 |
|---|---|
| container_issue | 5 |
| container_start_page | 945 |
| container_title | Circulation (New York, N.Y.) |
| container_volume | 62 |
| creator | Kloner, R A Rude, R E Carlson, N Maroko, P R DeBoer, L W Braunwald, E |
| description | Both microvascular damage and myocardial cell injury occur after coronary occlusion, but the relationship of these two events is unclear; specifically, it is unknown whether microvascular damage causes myocardial cell injury. Dogs were subjected to coronary occlusion for 20, 40, 60, 90 or 180 minutes, after which subendocardial and subepicardial biopsies were obtained for electron and light microscopy of 1-mu sections. Of 312 biopsies of ischemic myocadium, 181 showed myocardial cell injury with no microvascular damage; 131 showed myocardial cell injury and microvascular damage; but none showed microvascular damage without myocardial cell injury. Although ultrastructural evidence of myocardial cell damage was present in the subendocardium after 20-40 minutes of ischemia, ultrastructural evidence of microvascular damage was not prominent until 60-90 minutes after coronary artery occlusion. Morphologic ultrastructural evidence of microvascular damage lagged behind myocardial cell injury, suggesting that ultrastructural microvascular damage is not a primary cause of ultrastructural myocardial cell injury. |
| doi_str_mv | 10.1161/01.cir.62.5.945 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75270952</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>75270952</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4005-f29176d676303102fe92f04f1c89db9965a941b5854deddace0c1acf5f0501c23</originalsourceid><addsrcrecordid>eNo9kM9LwzAcxYMoc07PnoScvLVL0qZdvIgMfwwGgrhzyL5JXEbbzKSd7OS_bsuGpy8PPu_xfQ-hW0pSSgs6JTQFF9KCpTwVOT9DY8pZnuQ8E-doTAgRSZkxdomuYtz2sshKPkKjMqczWoox-l1VbVCxDR20XVAVNnunTQMGe4trB8HvVYSuUgFrVasvg1WjcX3woIJ2PQ-mqrBrtl04YGVbEzD44Bs1yNDLA_YAVRedbx7wz8bBpgdqE7F1IbaP1-jCqiqam9OdoNXL8-f8LVm-vy7mT8sEckJ4YpmgZaGLsshIRgmzRjBLckthJvRaiIIrkdM1n_FcG60VGAJUgeWWcEKBZRN0f8zdBf_dmdjK2sXhd9UY30VZclYSwQdwegT76jEGY-UuuLqvIymRw-SSUDlffMiCSS77yXvH3Sm6W9dG__OnjbM_MwB_nQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75270952</pqid></control><display><type>article</type><title>Ultrastructural evidence of microvascular damage and myocardial cell injury after coronary artery occlusion: which comes first?</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Journals@Ovid Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Kloner, R A ; Rude, R E ; Carlson, N ; Maroko, P R ; DeBoer, L W ; Braunwald, E</creator><creatorcontrib>Kloner, R A ; Rude, R E ; Carlson, N ; Maroko, P R ; DeBoer, L W ; Braunwald, E</creatorcontrib><description>Both microvascular damage and myocardial cell injury occur after coronary occlusion, but the relationship of these two events is unclear; specifically, it is unknown whether microvascular damage causes myocardial cell injury. Dogs were subjected to coronary occlusion for 20, 40, 60, 90 or 180 minutes, after which subendocardial and subepicardial biopsies were obtained for electron and light microscopy of 1-mu sections. Of 312 biopsies of ischemic myocadium, 181 showed myocardial cell injury with no microvascular damage; 131 showed myocardial cell injury and microvascular damage; but none showed microvascular damage without myocardial cell injury. Although ultrastructural evidence of myocardial cell damage was present in the subendocardium after 20-40 minutes of ischemia, ultrastructural evidence of microvascular damage was not prominent until 60-90 minutes after coronary artery occlusion. Morphologic ultrastructural evidence of microvascular damage lagged behind myocardial cell injury, suggesting that ultrastructural microvascular damage is not a primary cause of ultrastructural myocardial cell injury.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.cir.62.5.945</identifier><identifier>PMID: 7418179</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Arterial Occlusive Diseases - pathology ; Coronary Vessels ; Dogs ; Endothelium - ultrastructure ; Heart Injuries - pathology ; Microcirculation ; Myocardium - ultrastructure</subject><ispartof>Circulation (New York, N.Y.), 1980-11, Vol.62 (5), p.945-952</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4005-f29176d676303102fe92f04f1c89db9965a941b5854deddace0c1acf5f0501c23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3673,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7418179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kloner, R A</creatorcontrib><creatorcontrib>Rude, R E</creatorcontrib><creatorcontrib>Carlson, N</creatorcontrib><creatorcontrib>Maroko, P R</creatorcontrib><creatorcontrib>DeBoer, L W</creatorcontrib><creatorcontrib>Braunwald, E</creatorcontrib><title>Ultrastructural evidence of microvascular damage and myocardial cell injury after coronary artery occlusion: which comes first?</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Both microvascular damage and myocardial cell injury occur after coronary occlusion, but the relationship of these two events is unclear; specifically, it is unknown whether microvascular damage causes myocardial cell injury. Dogs were subjected to coronary occlusion for 20, 40, 60, 90 or 180 minutes, after which subendocardial and subepicardial biopsies were obtained for electron and light microscopy of 1-mu sections. Of 312 biopsies of ischemic myocadium, 181 showed myocardial cell injury with no microvascular damage; 131 showed myocardial cell injury and microvascular damage; but none showed microvascular damage without myocardial cell injury. Although ultrastructural evidence of myocardial cell damage was present in the subendocardium after 20-40 minutes of ischemia, ultrastructural evidence of microvascular damage was not prominent until 60-90 minutes after coronary artery occlusion. Morphologic ultrastructural evidence of microvascular damage lagged behind myocardial cell injury, suggesting that ultrastructural microvascular damage is not a primary cause of ultrastructural myocardial cell injury.</description><subject>Animals</subject><subject>Arterial Occlusive Diseases - pathology</subject><subject>Coronary Vessels</subject><subject>Dogs</subject><subject>Endothelium - ultrastructure</subject><subject>Heart Injuries - pathology</subject><subject>Microcirculation</subject><subject>Myocardium - ultrastructure</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM9LwzAcxYMoc07PnoScvLVL0qZdvIgMfwwGgrhzyL5JXEbbzKSd7OS_bsuGpy8PPu_xfQ-hW0pSSgs6JTQFF9KCpTwVOT9DY8pZnuQ8E-doTAgRSZkxdomuYtz2sshKPkKjMqczWoox-l1VbVCxDR20XVAVNnunTQMGe4trB8HvVYSuUgFrVasvg1WjcX3woIJ2PQ-mqrBrtl04YGVbEzD44Bs1yNDLA_YAVRedbx7wz8bBpgdqE7F1IbaP1-jCqiqam9OdoNXL8-f8LVm-vy7mT8sEckJ4YpmgZaGLsshIRgmzRjBLckthJvRaiIIrkdM1n_FcG60VGAJUgeWWcEKBZRN0f8zdBf_dmdjK2sXhd9UY30VZclYSwQdwegT76jEGY-UuuLqvIymRw-SSUDlffMiCSS77yXvH3Sm6W9dG__OnjbM_MwB_nQ</recordid><startdate>198011</startdate><enddate>198011</enddate><creator>Kloner, R A</creator><creator>Rude, R E</creator><creator>Carlson, N</creator><creator>Maroko, P R</creator><creator>DeBoer, L W</creator><creator>Braunwald, E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198011</creationdate><title>Ultrastructural evidence of microvascular damage and myocardial cell injury after coronary artery occlusion: which comes first?</title><author>Kloner, R A ; Rude, R E ; Carlson, N ; Maroko, P R ; DeBoer, L W ; Braunwald, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4005-f29176d676303102fe92f04f1c89db9965a941b5854deddace0c1acf5f0501c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Arterial Occlusive Diseases - pathology</topic><topic>Coronary Vessels</topic><topic>Dogs</topic><topic>Endothelium - ultrastructure</topic><topic>Heart Injuries - pathology</topic><topic>Microcirculation</topic><topic>Myocardium - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kloner, R A</creatorcontrib><creatorcontrib>Rude, R E</creatorcontrib><creatorcontrib>Carlson, N</creatorcontrib><creatorcontrib>Maroko, P R</creatorcontrib><creatorcontrib>DeBoer, L W</creatorcontrib><creatorcontrib>Braunwald, E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kloner, R A</au><au>Rude, R E</au><au>Carlson, N</au><au>Maroko, P R</au><au>DeBoer, L W</au><au>Braunwald, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrastructural evidence of microvascular damage and myocardial cell injury after coronary artery occlusion: which comes first?</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1980-11</date><risdate>1980</risdate><volume>62</volume><issue>5</issue><spage>945</spage><epage>952</epage><pages>945-952</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><abstract>Both microvascular damage and myocardial cell injury occur after coronary occlusion, but the relationship of these two events is unclear; specifically, it is unknown whether microvascular damage causes myocardial cell injury. Dogs were subjected to coronary occlusion for 20, 40, 60, 90 or 180 minutes, after which subendocardial and subepicardial biopsies were obtained for electron and light microscopy of 1-mu sections. Of 312 biopsies of ischemic myocadium, 181 showed myocardial cell injury with no microvascular damage; 131 showed myocardial cell injury and microvascular damage; but none showed microvascular damage without myocardial cell injury. Although ultrastructural evidence of myocardial cell damage was present in the subendocardium after 20-40 minutes of ischemia, ultrastructural evidence of microvascular damage was not prominent until 60-90 minutes after coronary artery occlusion. Morphologic ultrastructural evidence of microvascular damage lagged behind myocardial cell injury, suggesting that ultrastructural microvascular damage is not a primary cause of ultrastructural myocardial cell injury.</abstract><cop>United States</cop><pmid>7418179</pmid><doi>10.1161/01.cir.62.5.945</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 1980-11, Vol.62 (5), p.945-952 |
| issn | 0009-7322 1524-4539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75270952 |
| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Arterial Occlusive Diseases - pathology Coronary Vessels Dogs Endothelium - ultrastructure Heart Injuries - pathology Microcirculation Myocardium - ultrastructure |
| title | Ultrastructural evidence of microvascular damage and myocardial cell injury after coronary artery occlusion: which comes first? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T14%3A06%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ultrastructural%20evidence%20of%20microvascular%20damage%20and%20myocardial%20cell%20injury%20after%20coronary%20artery%20occlusion:%20which%20comes%20first?&rft.jtitle=Circulation%20(New%20York,%20N.Y.)&rft.au=Kloner,%20R%20A&rft.date=1980-11&rft.volume=62&rft.issue=5&rft.spage=945&rft.epage=952&rft.pages=945-952&rft.issn=0009-7322&rft.eissn=1524-4539&rft_id=info:doi/10.1161/01.cir.62.5.945&rft_dat=%3Cproquest_cross%3E75270952%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75270952&rft_id=info:pmid/7418179&rfr_iscdi=true |