Monoamine oxidase and catechol-o-methyltransferase activities in cultured fibroblasts and blood cells from children with autism and the Gilles de la Tourette syndrome
Monoamine oxidase (MAO) and catechol- O-methyltransferase (COMT) activities were measured in cells from children with autism ( n=5) and the Gilles de la Tourette syndrome ( n=5). Monoamine oxidase activities in cultured skin fibroblasts (type A) and platelets (type B) from the same individual were n...
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| Veröffentlicht in: | Psychiatry research 1980-05, Vol.2 (2), p.187-197 |
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| creator | Giller, Earl L. Young, J.Gerald Breakefield, Xandra O. Carbonari, Claudia Braverman, Muriel Cohen, Donald J. |
| description | Monoamine oxidase (MAO) and catechol-
O-methyltransferase (COMT) activities were measured in cells from children with autism (
n=5) and the Gilles de la Tourette syndrome (
n=5). Monoamine oxidase activities in cultured skin fibroblasts (type A) and platelets (type B) from the same individual were not correlated. COMT activities in fibroblasts and red blood cells showed a negative but not significant correlation (
r=-0.42). Fibroblast MAO and COMT activities from patients were similar to values from controls matched for age, race, and sex. Increasing clinical severity of illness in both disorders, however, correlated significantly with higher fibroblast MAO activity. Cultured fibroblasts provide a means of measuring enzyme activities independently of the individual's current physiological and psychological state. |
| doi_str_mv | 10.1016/0165-1781(80)90076-1 |
| format | Article |
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O-methyltransferase (COMT) activities were measured in cells from children with autism (
n=5) and the Gilles de la Tourette syndrome (
n=5). Monoamine oxidase activities in cultured skin fibroblasts (type A) and platelets (type B) from the same individual were not correlated. COMT activities in fibroblasts and red blood cells showed a negative but not significant correlation (
r=-0.42). Fibroblast MAO and COMT activities from patients were similar to values from controls matched for age, race, and sex. Increasing clinical severity of illness in both disorders, however, correlated significantly with higher fibroblast MAO activity. Cultured fibroblasts provide a means of measuring enzyme activities independently of the individual's current physiological and psychological state.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/0165-1781(80)90076-1</identifier><identifier>PMID: 6932062</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adolescent ; autism ; Autistic Disorder - enzymology ; Blood Cells - enzymology ; Catechol O-Methyltransferase - blood ; Catechol O-Methyltransferase - metabolism ; catechol- O-methyltransferase ; Cells, Cultured ; Child ; Child, Preschool ; Female ; fibroblasts ; Fibroblasts - enzymology ; Gilles de la Tourette syndrome ; Humans ; Male ; Monoamine oxidase ; Monoamine Oxidase - blood ; Monoamine Oxidase - metabolism ; Tourette Syndrome - enzymology</subject><ispartof>Psychiatry research, 1980-05, Vol.2 (2), p.187-197</ispartof><rights>1980</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-fe104157563ff4673125b836c742b8a6581e734ffd1210d205a2954a4b9237d73</citedby><cites>FETCH-LOGICAL-c357t-fe104157563ff4673125b836c742b8a6581e734ffd1210d205a2954a4b9237d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-1781(80)90076-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6932062$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giller, Earl L.</creatorcontrib><creatorcontrib>Young, J.Gerald</creatorcontrib><creatorcontrib>Breakefield, Xandra O.</creatorcontrib><creatorcontrib>Carbonari, Claudia</creatorcontrib><creatorcontrib>Braverman, Muriel</creatorcontrib><creatorcontrib>Cohen, Donald J.</creatorcontrib><title>Monoamine oxidase and catechol-o-methyltransferase activities in cultured fibroblasts and blood cells from children with autism and the Gilles de la Tourette syndrome</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Monoamine oxidase (MAO) and catechol-
O-methyltransferase (COMT) activities were measured in cells from children with autism (
n=5) and the Gilles de la Tourette syndrome (
n=5). Monoamine oxidase activities in cultured skin fibroblasts (type A) and platelets (type B) from the same individual were not correlated. COMT activities in fibroblasts and red blood cells showed a negative but not significant correlation (
r=-0.42). Fibroblast MAO and COMT activities from patients were similar to values from controls matched for age, race, and sex. Increasing clinical severity of illness in both disorders, however, correlated significantly with higher fibroblast MAO activity. Cultured fibroblasts provide a means of measuring enzyme activities independently of the individual's current physiological and psychological state.</description><subject>Adolescent</subject><subject>autism</subject><subject>Autistic Disorder - enzymology</subject><subject>Blood Cells - enzymology</subject><subject>Catechol O-Methyltransferase - blood</subject><subject>Catechol O-Methyltransferase - metabolism</subject><subject>catechol- O-methyltransferase</subject><subject>Cells, Cultured</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>fibroblasts</subject><subject>Fibroblasts - enzymology</subject><subject>Gilles de la Tourette syndrome</subject><subject>Humans</subject><subject>Male</subject><subject>Monoamine oxidase</subject><subject>Monoamine Oxidase - blood</subject><subject>Monoamine Oxidase - metabolism</subject><subject>Tourette Syndrome - enzymology</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFTEQhYMo43X0DRSyEl205qfT6d4IMugojLgZ1yGdVOhIOhmT9Oh9IZ_T3B9m6aKoRZ3zFVUHoZeUvKOEDu9biY7Kkb4ZyduJEDl09BHa0VGyTlLGH6Pdg-QpelbKT0IIo9N0gS6GiTMysB36-y3FpFcfAac_3uoCWEeLja5glhS61K1Ql32oWcfiIB8Fpvp7Xz0U7CM2W6hbBoudn3Oagy61HBlzSKmRIISCXU4rNosPNkPEv31dsN6qL-tRWRfA1z6EBrSAg8a3qRFrBVz20TYrPEdPnA4FXpz7Jfrx-dPt1Zfu5vv116uPN53hQtbOASU9FVIM3Ll-kJwyMY98MLJn86gHMVKQvHfOUkaJZURoNole9_PEuLSSX6LXJ-5dTr82KFWtvhxO0BHSVpQUTEjOWRP2J6HJqZQMTt1lv-q8V5SoQzzq8Ht1-L0aiTrGo2izvTrzt3kF-2A659HmH05zaEfee8iqGA_RgPUZTFU2-f8v-AfFsaGQ</recordid><startdate>198005</startdate><enddate>198005</enddate><creator>Giller, Earl L.</creator><creator>Young, J.Gerald</creator><creator>Breakefield, Xandra O.</creator><creator>Carbonari, Claudia</creator><creator>Braverman, Muriel</creator><creator>Cohen, Donald J.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198005</creationdate><title>Monoamine oxidase and catechol-o-methyltransferase activities in cultured fibroblasts and blood cells from children with autism and the Gilles de la Tourette syndrome</title><author>Giller, Earl L. ; Young, J.Gerald ; Breakefield, Xandra O. ; Carbonari, Claudia ; Braverman, Muriel ; Cohen, Donald J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-fe104157563ff4673125b836c742b8a6581e734ffd1210d205a2954a4b9237d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Adolescent</topic><topic>autism</topic><topic>Autistic Disorder - enzymology</topic><topic>Blood Cells - enzymology</topic><topic>Catechol O-Methyltransferase - blood</topic><topic>Catechol O-Methyltransferase - metabolism</topic><topic>catechol- O-methyltransferase</topic><topic>Cells, Cultured</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>fibroblasts</topic><topic>Fibroblasts - enzymology</topic><topic>Gilles de la Tourette syndrome</topic><topic>Humans</topic><topic>Male</topic><topic>Monoamine oxidase</topic><topic>Monoamine Oxidase - blood</topic><topic>Monoamine Oxidase - metabolism</topic><topic>Tourette Syndrome - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giller, Earl L.</creatorcontrib><creatorcontrib>Young, J.Gerald</creatorcontrib><creatorcontrib>Breakefield, Xandra O.</creatorcontrib><creatorcontrib>Carbonari, Claudia</creatorcontrib><creatorcontrib>Braverman, Muriel</creatorcontrib><creatorcontrib>Cohen, Donald J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giller, Earl L.</au><au>Young, J.Gerald</au><au>Breakefield, Xandra O.</au><au>Carbonari, Claudia</au><au>Braverman, Muriel</au><au>Cohen, Donald J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monoamine oxidase and catechol-o-methyltransferase activities in cultured fibroblasts and blood cells from children with autism and the Gilles de la Tourette syndrome</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>1980-05</date><risdate>1980</risdate><volume>2</volume><issue>2</issue><spage>187</spage><epage>197</epage><pages>187-197</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><abstract>Monoamine oxidase (MAO) and catechol-
O-methyltransferase (COMT) activities were measured in cells from children with autism (
n=5) and the Gilles de la Tourette syndrome (
n=5). Monoamine oxidase activities in cultured skin fibroblasts (type A) and platelets (type B) from the same individual were not correlated. COMT activities in fibroblasts and red blood cells showed a negative but not significant correlation (
r=-0.42). Fibroblast MAO and COMT activities from patients were similar to values from controls matched for age, race, and sex. Increasing clinical severity of illness in both disorders, however, correlated significantly with higher fibroblast MAO activity. Cultured fibroblasts provide a means of measuring enzyme activities independently of the individual's current physiological and psychological state.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>6932062</pmid><doi>10.1016/0165-1781(80)90076-1</doi><tpages>11</tpages></addata></record> |
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| identifier | ISSN: 0165-1781 |
| ispartof | Psychiatry research, 1980-05, Vol.2 (2), p.187-197 |
| issn | 0165-1781 1872-7123 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent autism Autistic Disorder - enzymology Blood Cells - enzymology Catechol O-Methyltransferase - blood Catechol O-Methyltransferase - metabolism catechol- O-methyltransferase Cells, Cultured Child Child, Preschool Female fibroblasts Fibroblasts - enzymology Gilles de la Tourette syndrome Humans Male Monoamine oxidase Monoamine Oxidase - blood Monoamine Oxidase - metabolism Tourette Syndrome - enzymology |
| title | Monoamine oxidase and catechol-o-methyltransferase activities in cultured fibroblasts and blood cells from children with autism and the Gilles de la Tourette syndrome |
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