Phase Variation: Evolution of a Controlling Element
Phase variation in bacteria is regulated by homologous recombination at a specific DNA site. This recombinational event causes the inversion of a 970-base-pair DNA sequence that includes the promoter necessary for transcription of a flagellar gene. The invertible segment is flanked by two sites that...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1980-09, Vol.209 (4463), p.1370-1374 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Simon, Melvin Zieg, Janine Silverman, Michael Mandel, Gail Doolittle, Russell |
| description | Phase variation in bacteria is regulated by homologous recombination at a specific DNA site. This recombinational event causes the inversion of a 970-base-pair DNA sequence that includes the promoter necessary for transcription of a flagellar gene. The invertible segment is flanked by two sites that are necessary for the inversion and contains a gene (hin) whose product mediates the inversion event. The hin gene shows extensive homology with the TnpR gene carried on the Tn3 transposon. It is also homologous with the gin gene carried on bacteriophage mu. These relationships suggest that the phase variation system may have evolved by the association of a transposon with a resident gene and the subsequent specialization of these elements to regulate flagellar antigen expression. |
| doi_str_mv | 10.1126/science.6251543 |
| format | Article |
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This recombinational event causes the inversion of a 970-base-pair DNA sequence that includes the promoter necessary for transcription of a flagellar gene. The invertible segment is flanked by two sites that are necessary for the inversion and contains a gene (hin) whose product mediates the inversion event. The hin gene shows extensive homology with the TnpR gene carried on the Tn3 transposon. It is also homologous with the gin gene carried on bacteriophage mu. 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These relationships suggest that the phase variation system may have evolved by the association of a transposon with a resident gene and the subsequent specialization of these elements to regulate flagellar antigen expression.</description><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Bacterial Proteins - genetics</subject><subject>Base Sequence</subject><subject>DNA</subject><subject>DNA Transposable Elements</subject><subject>DNA, Bacterial - genetics</subject><subject>Flagellin - genetics</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genes Whose Mission is to Jump</subject><subject>Genetic transposition</subject><subject>Genetic variation</subject><subject>Nucleotide sequences</subject><subject>Plasmids</subject><subject>Promoter regions</subject><subject>Recombination, Genetic</subject><subject>Salmonella - genetics</subject><subject>Transposons</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkL1PwzAQxS0EKqUws4CUiS2tHceXhA1V5UOqBAOwWo5zhlROXOykEv89qRrR6U56v3un9wi5ZnTOWAKLoGtsNc4hEUyk_IRMGS1EXCSUn5IppRzinGbinFyEsKF00Ao-IZMRnxL-9q0CRp_K16qrXXsfrXbO9vs1ciZS0dK1nXfW1u1XtLLYYNtdkjOjbMCrcc7Ix-Pqffkcr1-fXpYP61jzNO3irGCKMtAaWJqWuqxSowB4ZdDkFS8zUZoEckZRGITU0IqVmDCmK02BAwg-I3cH3613Pz2GTjZ10GitatH1QWYiEZAV2QAuDqD2LgSPRm593Sj_KxmV-5rkWJMccw8Xt6N1XzZY_fNH_eagb0Ln_NEOcsGGh3_SOm1l</recordid><startdate>19800919</startdate><enddate>19800919</enddate><creator>Simon, Melvin</creator><creator>Zieg, Janine</creator><creator>Silverman, Michael</creator><creator>Mandel, Gail</creator><creator>Doolittle, Russell</creator><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19800919</creationdate><title>Phase Variation: Evolution of a Controlling Element</title><author>Simon, Melvin ; Zieg, Janine ; Silverman, Michael ; Mandel, Gail ; Doolittle, Russell</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-791a016cc6144bcbd4fa663dfef8d3b75bf26810e5fe64f0d1be211cdc0636653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Bacterial Proteins - genetics</topic><topic>Base Sequence</topic><topic>DNA</topic><topic>DNA Transposable Elements</topic><topic>DNA, Bacterial - genetics</topic><topic>Flagellin - genetics</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genes Whose Mission is to Jump</topic><topic>Genetic transposition</topic><topic>Genetic variation</topic><topic>Nucleotide sequences</topic><topic>Plasmids</topic><topic>Promoter regions</topic><topic>Recombination, Genetic</topic><topic>Salmonella - genetics</topic><topic>Transposons</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Simon, Melvin</creatorcontrib><creatorcontrib>Zieg, Janine</creatorcontrib><creatorcontrib>Silverman, Michael</creatorcontrib><creatorcontrib>Mandel, Gail</creatorcontrib><creatorcontrib>Doolittle, Russell</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simon, Melvin</au><au>Zieg, Janine</au><au>Silverman, Michael</au><au>Mandel, Gail</au><au>Doolittle, Russell</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phase Variation: Evolution of a Controlling Element</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1980-09-19</date><risdate>1980</risdate><volume>209</volume><issue>4463</issue><spage>1370</spage><epage>1374</epage><pages>1370-1374</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Phase variation in bacteria is regulated by homologous recombination at a specific DNA site. 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1980-09, Vol.209 (4463), p.1370-1374 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75256797 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Amino Acid Sequence Amino acids Bacterial Proteins - genetics Base Sequence DNA DNA Transposable Elements DNA, Bacterial - genetics Flagellin - genetics Gene expression Genes Genes Whose Mission is to Jump Genetic transposition Genetic variation Nucleotide sequences Plasmids Promoter regions Recombination, Genetic Salmonella - genetics Transposons |
| title | Phase Variation: Evolution of a Controlling Element |
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