Immunostimulatory effects of arginine in normal and injured rats
We have shown in the present experiments that femoral fractures, particularly bilateral fractures, lead to impaired thymic function in rats as assessed by thymic size, numbers of thymic lymphocytes, and ability of thymic lymphocytes to respond to mitogenic stimulation. The in vitro depression in T-c...
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| Veröffentlicht in: | The Journal of surgical research 1980-09, Vol.29 (3), p.228-235 |
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| container_title | The Journal of surgical research |
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| creator | Barbul, Adrian Wasserkrug, Hannah L. Seifter, Eli Rettura, Giuseppe Levenson, Stanley M. Efron, Gershon |
| description | We have shown in the present experiments that femoral fractures, particularly bilateral fractures, lead to impaired thymic function in rats as assessed by thymic size, numbers of thymic lymphocytes, and ability of thymic lymphocytes to respond to mitogenic stimulation. The
in vitro depression in T-cell function appears to be a primary one since it is also observed in serum-free microculture systems. We have also shown that 1% dietary arginine supplementation largely prevents or minimizes the thymolysis and T-cell dysfunction that appear post-trauma. In addition, dietary supplemental arginine significantly increases thymic weight, cellularity, and T-cell blastogenic responsiveness in uninjured rats. This suggests that arginine may be a safe nutritional means of correcting immune depression in injured and/or stressed patients. |
| doi_str_mv | 10.1016/0022-4804(80)90165-1 |
| format | Article |
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in vitro depression in T-cell function appears to be a primary one since it is also observed in serum-free microculture systems. We have also shown that 1% dietary arginine supplementation largely prevents or minimizes the thymolysis and T-cell dysfunction that appear post-trauma. In addition, dietary supplemental arginine significantly increases thymic weight, cellularity, and T-cell blastogenic responsiveness in uninjured rats. This suggests that arginine may be a safe nutritional means of correcting immune depression in injured and/or stressed patients.</description><identifier>ISSN: 0022-4804</identifier><identifier>EISSN: 1095-8673</identifier><identifier>DOI: 10.1016/0022-4804(80)90165-1</identifier><identifier>PMID: 6968002</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Arginine - metabolism ; Concanavalin A - pharmacology ; Femoral Fractures - diet therapy ; Femoral Fractures - immunology ; In Vitro Techniques ; Male ; Organ Size ; Phytohemagglutinins - pharmacology ; Protein Biosynthesis ; Rats ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism ; Thymus Gland - analysis ; Thymus Gland - cytology ; Wounds and Injuries - metabolism</subject><ispartof>The Journal of surgical research, 1980-09, Vol.29 (3), p.228-235</ispartof><rights>1980</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-37ef865250adff9dd7cce181bb1744c2588665499f366fb2660d84a5a100c4db3</citedby><cites>FETCH-LOGICAL-c423t-37ef865250adff9dd7cce181bb1744c2588665499f366fb2660d84a5a100c4db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0022-4804(80)90165-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6968002$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barbul, Adrian</creatorcontrib><creatorcontrib>Wasserkrug, Hannah L.</creatorcontrib><creatorcontrib>Seifter, Eli</creatorcontrib><creatorcontrib>Rettura, Giuseppe</creatorcontrib><creatorcontrib>Levenson, Stanley M.</creatorcontrib><creatorcontrib>Efron, Gershon</creatorcontrib><title>Immunostimulatory effects of arginine in normal and injured rats</title><title>The Journal of surgical research</title><addtitle>J Surg Res</addtitle><description>We have shown in the present experiments that femoral fractures, particularly bilateral fractures, lead to impaired thymic function in rats as assessed by thymic size, numbers of thymic lymphocytes, and ability of thymic lymphocytes to respond to mitogenic stimulation. The
in vitro depression in T-cell function appears to be a primary one since it is also observed in serum-free microculture systems. We have also shown that 1% dietary arginine supplementation largely prevents or minimizes the thymolysis and T-cell dysfunction that appear post-trauma. In addition, dietary supplemental arginine significantly increases thymic weight, cellularity, and T-cell blastogenic responsiveness in uninjured rats. This suggests that arginine may be a safe nutritional means of correcting immune depression in injured and/or stressed patients.</description><subject>Animals</subject><subject>Arginine - metabolism</subject><subject>Concanavalin A - pharmacology</subject><subject>Femoral Fractures - diet therapy</subject><subject>Femoral Fractures - immunology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Organ Size</subject><subject>Phytohemagglutinins - pharmacology</subject><subject>Protein Biosynthesis</subject><subject>Rats</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><subject>Thymus Gland - analysis</subject><subject>Thymus Gland - cytology</subject><subject>Wounds and Injuries - metabolism</subject><issn>0022-4804</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LAzEQxYMotVa_gcKeRA-ryW42m72IUvxTKHjRc8gmE0nZTWqyK_Tbm9rSo6fhzbx5w_wQuiT4jmDC7jEuipxyTG84vm1Sp8rJEZoS3FQ5Z3V5jKYHyyk6i3GFk27qcoImrGE8iSl6XPT96HwcbD92cvBhk4ExoIaYeZPJ8GWddZBZlzkfetll0umkVmMAnQU5xHN0YmQX4WJfZ-jz5flj_pYv318X86dlrmhRDnlZg-GsKiostTGN1rVSQDhpW1JTqoqKc8Yq2jSmZMy0BWNYcyorSTBWVLflDF3vctfBf48QB9HbqKDrpAM_RlFvs2nNk5HujCr4GAMYsQ62l2EjCBZbcGJLRWypCI7FHzhB0trVPn9se9CHpT2pNH_YzSE9-WMhiKgsOAXahoRLaG__P_ALDrJ8OA</recordid><startdate>198009</startdate><enddate>198009</enddate><creator>Barbul, Adrian</creator><creator>Wasserkrug, Hannah L.</creator><creator>Seifter, Eli</creator><creator>Rettura, Giuseppe</creator><creator>Levenson, Stanley M.</creator><creator>Efron, Gershon</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198009</creationdate><title>Immunostimulatory effects of arginine in normal and injured rats</title><author>Barbul, Adrian ; Wasserkrug, Hannah L. ; Seifter, Eli ; Rettura, Giuseppe ; Levenson, Stanley M. ; Efron, Gershon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-37ef865250adff9dd7cce181bb1744c2588665499f366fb2660d84a5a100c4db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Arginine - metabolism</topic><topic>Concanavalin A - pharmacology</topic><topic>Femoral Fractures - diet therapy</topic><topic>Femoral Fractures - immunology</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Organ Size</topic><topic>Phytohemagglutinins - pharmacology</topic><topic>Protein Biosynthesis</topic><topic>Rats</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - metabolism</topic><topic>Thymus Gland - analysis</topic><topic>Thymus Gland - cytology</topic><topic>Wounds and Injuries - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barbul, Adrian</creatorcontrib><creatorcontrib>Wasserkrug, Hannah L.</creatorcontrib><creatorcontrib>Seifter, Eli</creatorcontrib><creatorcontrib>Rettura, Giuseppe</creatorcontrib><creatorcontrib>Levenson, Stanley M.</creatorcontrib><creatorcontrib>Efron, Gershon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barbul, Adrian</au><au>Wasserkrug, Hannah L.</au><au>Seifter, Eli</au><au>Rettura, Giuseppe</au><au>Levenson, Stanley M.</au><au>Efron, Gershon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunostimulatory effects of arginine in normal and injured rats</atitle><jtitle>The Journal of surgical research</jtitle><addtitle>J Surg Res</addtitle><date>1980-09</date><risdate>1980</risdate><volume>29</volume><issue>3</issue><spage>228</spage><epage>235</epage><pages>228-235</pages><issn>0022-4804</issn><eissn>1095-8673</eissn><abstract>We have shown in the present experiments that femoral fractures, particularly bilateral fractures, lead to impaired thymic function in rats as assessed by thymic size, numbers of thymic lymphocytes, and ability of thymic lymphocytes to respond to mitogenic stimulation. The
in vitro depression in T-cell function appears to be a primary one since it is also observed in serum-free microculture systems. We have also shown that 1% dietary arginine supplementation largely prevents or minimizes the thymolysis and T-cell dysfunction that appear post-trauma. In addition, dietary supplemental arginine significantly increases thymic weight, cellularity, and T-cell blastogenic responsiveness in uninjured rats. This suggests that arginine may be a safe nutritional means of correcting immune depression in injured and/or stressed patients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6968002</pmid><doi>10.1016/0022-4804(80)90165-1</doi><tpages>8</tpages></addata></record> |
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| ispartof | The Journal of surgical research, 1980-09, Vol.29 (3), p.228-235 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Arginine - metabolism Concanavalin A - pharmacology Femoral Fractures - diet therapy Femoral Fractures - immunology In Vitro Techniques Male Organ Size Phytohemagglutinins - pharmacology Protein Biosynthesis Rats T-Lymphocytes - immunology T-Lymphocytes - metabolism Thymus Gland - analysis Thymus Gland - cytology Wounds and Injuries - metabolism |
| title | Immunostimulatory effects of arginine in normal and injured rats |
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