Differential lipemic and proteinemic response to oral ethinyl estradiol and parenteral estradiol cypionate
Oral synthetic estrogen administration to normal women has been shown to result in both a lipemic and a proteinemic response. To determine whether parenteral estrogen administration would have similar results, the effects of intramuscular depo-estradiol cypionate on serum lipids and ceruloplasmin we...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 1980-09, Vol.29 (9), p.803-805 |
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| container_title | Metabolism, clinical and experimental |
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| creator | Buckman, Maire T. Johnson, Judy Ellis, Harry Srivastava, Laxmi Peake, Glenn T. |
| description | Oral synthetic estrogen administration to normal women has been shown to result in both a lipemic and a proteinemic response. To determine whether parenteral estrogen administration would have similar results, the effects of intramuscular depo-estradiol cypionate on serum lipids and ceruloplasmin were examined. The oral and parenteral estrogens chosen for this study are frequently used therapeutically and varying doses in the range of those commonly employed clinically were given to the experimental subjects. Following oral ethinyl estradiol (20, 50, and 100 μg every 12 hr) comparable and significant increases in triglyceride (73 ± 6 to 128 ± 10 mg/dl,
p < .001), ceruloplasmin (87 ± 4 to 188 ± 11 mg/dl,
p < .001), and HDL-cholesterol (60 ± 2 to 74 ± 3 mg/dl,
p < .001) were observed. In contrast, despite substantial increases in serum estrogens, parenteral estrogen administration (depo-estradiol cypionate, 5 and 10 mg) failed to result in alterations in any of the measured parameters. Thus, the route and/or type of estrogen administered may determine the proteinemic and lipemic effects of estrogen in man. |
| doi_str_mv | 10.1016/0026-0495(80)90117-1 |
| format | Article |
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p < .001), ceruloplasmin (87 ± 4 to 188 ± 11 mg/dl,
p < .001), and HDL-cholesterol (60 ± 2 to 74 ± 3 mg/dl,
p < .001) were observed. In contrast, despite substantial increases in serum estrogens, parenteral estrogen administration (depo-estradiol cypionate, 5 and 10 mg) failed to result in alterations in any of the measured parameters. Thus, the route and/or type of estrogen administered may determine the proteinemic and lipemic effects of estrogen in man.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/0026-0495(80)90117-1</identifier><identifier>PMID: 7412555</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Administration, Oral ; Adolescent ; Adult ; Blood Proteins - metabolism ; Ceruloplasmin - metabolism ; Cholesterol - blood ; Estradiol - administration & dosage ; Estradiol - analogs & derivatives ; Estrogens - blood ; Ethinyl Estradiol - administration & dosage ; Female ; Humans ; Injections, Intramuscular ; Lipids - blood ; Lipoproteins, HDL - blood ; Population ; Triglycerides - blood</subject><ispartof>Metabolism, clinical and experimental, 1980-09, Vol.29 (9), p.803-805</ispartof><rights>1980</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-1120f47ed56ed481ad7c38ce48097f9075ae8d0141cdae83c490aafa00c0f1463</citedby><cites>FETCH-LOGICAL-c357t-1120f47ed56ed481ad7c38ce48097f9075ae8d0141cdae83c490aafa00c0f1463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0026049580901171$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7412555$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buckman, Maire T.</creatorcontrib><creatorcontrib>Johnson, Judy</creatorcontrib><creatorcontrib>Ellis, Harry</creatorcontrib><creatorcontrib>Srivastava, Laxmi</creatorcontrib><creatorcontrib>Peake, Glenn T.</creatorcontrib><title>Differential lipemic and proteinemic response to oral ethinyl estradiol and parenteral estradiol cypionate</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>Oral synthetic estrogen administration to normal women has been shown to result in both a lipemic and a proteinemic response. To determine whether parenteral estrogen administration would have similar results, the effects of intramuscular depo-estradiol cypionate on serum lipids and ceruloplasmin were examined. The oral and parenteral estrogens chosen for this study are frequently used therapeutically and varying doses in the range of those commonly employed clinically were given to the experimental subjects. Following oral ethinyl estradiol (20, 50, and 100 μg every 12 hr) comparable and significant increases in triglyceride (73 ± 6 to 128 ± 10 mg/dl,
p < .001), ceruloplasmin (87 ± 4 to 188 ± 11 mg/dl,
p < .001), and HDL-cholesterol (60 ± 2 to 74 ± 3 mg/dl,
p < .001) were observed. In contrast, despite substantial increases in serum estrogens, parenteral estrogen administration (depo-estradiol cypionate, 5 and 10 mg) failed to result in alterations in any of the measured parameters. Thus, the route and/or type of estrogen administered may determine the proteinemic and lipemic effects of estrogen in man.</description><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Blood Proteins - metabolism</subject><subject>Ceruloplasmin - metabolism</subject><subject>Cholesterol - blood</subject><subject>Estradiol - administration & dosage</subject><subject>Estradiol - analogs & derivatives</subject><subject>Estrogens - blood</subject><subject>Ethinyl Estradiol - administration & dosage</subject><subject>Female</subject><subject>Humans</subject><subject>Injections, Intramuscular</subject><subject>Lipids - blood</subject><subject>Lipoproteins, HDL - blood</subject><subject>Population</subject><subject>Triglycerides - blood</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMo4zj6BgpdiS6qJ23StBtBxisMuNF1iMkJRtqmJh1h3t52OszS1Un4L8n5CDmncEOBFrcAWZECq_hVCdcVUCpSekDmlOdZWhYAh2S-txyTkxi_AUCIspiRmWA045zPyfeDsxYDtr1TdVK7DhunE9WapAu-R9du7wFj59uISe8THwYj9l-u3Qwz9kEZ5-sposYi3Br2gt50zreqx1NyZFUd8Ww3F-Tj6fF9-ZKu3p5fl_erVOdc9CmlGVgm0PACDSupMkLnpUZWQiVsBYIrLA1QRrUZTrlmFShlFYAGS1mRL8jl1Dts8LMePiIbFzXWtWrRr6MUPOPAcjoY2WTUwccY0MouuEaFjaQgR8Ry5CdHfrIEuUUsx9jFrn_92aDZh3ZMB_1u0nFY8tdhkFE7bDUaF1D30nj3_wN_2x6M3A</recordid><startdate>198009</startdate><enddate>198009</enddate><creator>Buckman, Maire T.</creator><creator>Johnson, Judy</creator><creator>Ellis, Harry</creator><creator>Srivastava, Laxmi</creator><creator>Peake, Glenn T.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198009</creationdate><title>Differential lipemic and proteinemic response to oral ethinyl estradiol and parenteral estradiol cypionate</title><author>Buckman, Maire T. ; Johnson, Judy ; Ellis, Harry ; Srivastava, Laxmi ; Peake, Glenn T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-1120f47ed56ed481ad7c38ce48097f9075ae8d0141cdae83c490aafa00c0f1463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Administration, Oral</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Blood Proteins - metabolism</topic><topic>Ceruloplasmin - metabolism</topic><topic>Cholesterol - blood</topic><topic>Estradiol - administration & dosage</topic><topic>Estradiol - analogs & derivatives</topic><topic>Estrogens - blood</topic><topic>Ethinyl Estradiol - administration & dosage</topic><topic>Female</topic><topic>Humans</topic><topic>Injections, Intramuscular</topic><topic>Lipids - blood</topic><topic>Lipoproteins, HDL - blood</topic><topic>Population</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buckman, Maire T.</creatorcontrib><creatorcontrib>Johnson, Judy</creatorcontrib><creatorcontrib>Ellis, Harry</creatorcontrib><creatorcontrib>Srivastava, Laxmi</creatorcontrib><creatorcontrib>Peake, Glenn T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buckman, Maire T.</au><au>Johnson, Judy</au><au>Ellis, Harry</au><au>Srivastava, Laxmi</au><au>Peake, Glenn T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential lipemic and proteinemic response to oral ethinyl estradiol and parenteral estradiol cypionate</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>1980-09</date><risdate>1980</risdate><volume>29</volume><issue>9</issue><spage>803</spage><epage>805</epage><pages>803-805</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>Oral synthetic estrogen administration to normal women has been shown to result in both a lipemic and a proteinemic response. To determine whether parenteral estrogen administration would have similar results, the effects of intramuscular depo-estradiol cypionate on serum lipids and ceruloplasmin were examined. The oral and parenteral estrogens chosen for this study are frequently used therapeutically and varying doses in the range of those commonly employed clinically were given to the experimental subjects. Following oral ethinyl estradiol (20, 50, and 100 μg every 12 hr) comparable and significant increases in triglyceride (73 ± 6 to 128 ± 10 mg/dl,
p < .001), ceruloplasmin (87 ± 4 to 188 ± 11 mg/dl,
p < .001), and HDL-cholesterol (60 ± 2 to 74 ± 3 mg/dl,
p < .001) were observed. In contrast, despite substantial increases in serum estrogens, parenteral estrogen administration (depo-estradiol cypionate, 5 and 10 mg) failed to result in alterations in any of the measured parameters. Thus, the route and/or type of estrogen administered may determine the proteinemic and lipemic effects of estrogen in man.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7412555</pmid><doi>10.1016/0026-0495(80)90117-1</doi><tpages>3</tpages></addata></record> |
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| ispartof | Metabolism, clinical and experimental, 1980-09, Vol.29 (9), p.803-805 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Administration, Oral Adolescent Adult Blood Proteins - metabolism Ceruloplasmin - metabolism Cholesterol - blood Estradiol - administration & dosage Estradiol - analogs & derivatives Estrogens - blood Ethinyl Estradiol - administration & dosage Female Humans Injections, Intramuscular Lipids - blood Lipoproteins, HDL - blood Population Triglycerides - blood |
| title | Differential lipemic and proteinemic response to oral ethinyl estradiol and parenteral estradiol cypionate |
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