Effect of photooxidation on the estrogen receptor from rat mammary tumor

Photooxidation of estradiol receptor form MTW9 rat mammary tumor cytosol leads to a time-dependent loss of DNA-binding activity; this effect is pH-dependent. Binding of receptor to DNA does not protect the DNA-binding site from photooxidation. The estrogen binding site of the receptor is also suscep...

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Veröffentlicht in:	The Journal of biological chemistry 1980-09, Vol.255 (18), p.8776-8779
Hauptverfasser:	Feldman, M, Kallos, J, Hollander, V P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytosol - metabolism Estradiol - metabolism Female Kinetics Mammary Neoplasms, Experimental - metabolism Oxidation-Reduction Photochemistry Rats Receptors, Estrogen - metabolism
Online-Zugang:	Volltext
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