The determination of verapamil in maternal and fetal blood (author's transl)

During the late first stage of labor and during the second stage of labor seven women in labor received an intravenous infusion during 60-110 minutes of verapamil at 2 g/k/per minute. Immediately following delivery of the infant, maternal and cord blood was drawn and the verapamil level measured by...

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Veröffentlicht in:Geburtshilfe und Frauenheilkunde 1980-06, Vol.40 (6), p.496-499
Hauptverfasser: Strigl, R, Gastroph, G, Hege, H G, Döring, P, Mehring, W
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creator Strigl, R
Gastroph, G
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Döring, P
Mehring, W
description During the late first stage of labor and during the second stage of labor seven women in labor received an intravenous infusion during 60-110 minutes of verapamil at 2 g/k/per minute. Immediately following delivery of the infant, maternal and cord blood was drawn and the verapamil level measured by gas chromatography. The serum levels in the maternal blood were from 5.4 to 33.6 ng/ml. (Mean value 19.3 +/- 3.3 ng/ml) and the cord blood concentrations were 4.3-17.8 ng/ml (Mean value 8.5 +/- 1.9 ng/ml). The mean fetal serum level of verapamil was 51.4% of the mean maternal value.
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subjects Female
Fetal Blood - analysis
Humans
Infant, Newborn
Labor Stage, Third
Maternal-Fetal Exchange
Methods
Pregnancy
Verapamil - blood
title The determination of verapamil in maternal and fetal blood (author's transl)
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