Inhibition of 3H-clozapine binding in rat brain after oral administration of neuroleptics

Clozapine, thioridazine, perlapine, clothiapine, chlorpromazine, NT 104–252, loxapine or haloperidol were administered orally, and atropine subcutaneously, to rats. The animals were decapitated, brain tissue was removed and homogenized in tris buffer and incubated with 3H-clozapine. Total and nonspe...

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Veröffentlicht in:	Life sciences (1973) 1980-06, Vol.26 (25), p.2187-2193
1. Verfasser:	Bürki, Hans R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipsychotic Agents - pharmacology Binding, Competitive Brain - drug effects Brain - metabolism Clozapine - metabolism Dibenzazepines - metabolism In Vitro Techniques Rats
Online-Zugang:	Volltext
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