QUANTITATIVE SCINTIGRAPHY IN THE EARLY DIAGNOSIS OF SACRO-ILIITIS
SUMMARY Bone scans were performed on 65 subjects including 13 healthy controls and 52 patients aged over 20 years with suspected sacro-iliitis. Patients were given 15 mCi of technetium-99m methylene diphosphonate (99mTcMDP) intravenously and 400 K count images were recorded two hours later from the...
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| Veröffentlicht in: | Rheumatology (Oxford, England) England), 1980-05, Vol.19 (2), p.69-75 |
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| creator | DUNN, E. CAROLINE EBRINGER, R. W. ELL, P. J. |
| description | SUMMARY Bone scans were performed on 65 subjects including 13 healthy controls and 52 patients aged over 20 years with suspected sacro-iliitis. Patients were given 15 mCi of technetium-99m methylene diphosphonate (99mTcMDP) intravenously and 400 K count images were recorded two hours later from the posterior pelvis and lower lumbar spine. Using a region of interest technique, counts were taken at three levels from each sacro-iliac joint and the central sacrum, and sacro-iliac/sacral (SI/S) ratios of uptake, and a sacro-iliac index (SI index) were calculated. High SI/S ratios and high SI indices were obtained in 15 patients with grades 0–2 sacro-iliac radiographs. Nine of these patients had clinically assessed ankylosing spondylitis (AS). Five patients with clinical AS, and grades 3 and 4 radiographs had normal SI indices. Quantitative scintigraphy appears to be useful in the diagnosis of early sacro-iliitis prior to the appearance of definite radiographic changes. Multilevel analysis, drug washout and background subtraction increase the sensitivity of the technique. |
| doi_str_mv | 10.1093/rheumatology/19.2.69 |
| format | Article |
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CAROLINE ; EBRINGER, R. W. ; ELL, P. J.</creator><creatorcontrib>DUNN, E. CAROLINE ; EBRINGER, R. W. ; ELL, P. J.</creatorcontrib><description>SUMMARY Bone scans were performed on 65 subjects including 13 healthy controls and 52 patients aged over 20 years with suspected sacro-iliitis. Patients were given 15 mCi of technetium-99m methylene diphosphonate (99mTcMDP) intravenously and 400 K count images were recorded two hours later from the posterior pelvis and lower lumbar spine. Using a region of interest technique, counts were taken at three levels from each sacro-iliac joint and the central sacrum, and sacro-iliac/sacral (SI/S) ratios of uptake, and a sacro-iliac index (SI index) were calculated. High SI/S ratios and high SI indices were obtained in 15 patients with grades 0–2 sacro-iliac radiographs. Nine of these patients had clinically assessed ankylosing spondylitis (AS). Five patients with clinical AS, and grades 3 and 4 radiographs had normal SI indices. Quantitative scintigraphy appears to be useful in the diagnosis of early sacro-iliitis prior to the appearance of definite radiographic changes. Multilevel analysis, drug washout and background subtraction increase the sensitivity of the technique.</description><identifier>ISSN: 1462-0324</identifier><identifier>ISSN: 0300-3396</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/19.2.69</identifier><identifier>PMID: 7403779</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Female ; Humans ; Male ; Middle Aged ; Radionuclide Imaging ; Sacroiliac Joint - diagnostic imaging ; Sacrum - diagnostic imaging ; Spondylitis, Ankylosing - diagnostic imaging ; Technetium</subject><ispartof>Rheumatology (Oxford, England), 1980-05, Vol.19 (2), p.69-75</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-ad2fa447a461fd9795d619a6733eb824f9373d65047bf88b8ef2409e414a45413</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7403779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DUNN, E. CAROLINE</creatorcontrib><creatorcontrib>EBRINGER, R. W.</creatorcontrib><creatorcontrib>ELL, P. J.</creatorcontrib><title>QUANTITATIVE SCINTIGRAPHY IN THE EARLY DIAGNOSIS OF SACRO-ILIITIS</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatol Rehabil</addtitle><description>SUMMARY Bone scans were performed on 65 subjects including 13 healthy controls and 52 patients aged over 20 years with suspected sacro-iliitis. Patients were given 15 mCi of technetium-99m methylene diphosphonate (99mTcMDP) intravenously and 400 K count images were recorded two hours later from the posterior pelvis and lower lumbar spine. Using a region of interest technique, counts were taken at three levels from each sacro-iliac joint and the central sacrum, and sacro-iliac/sacral (SI/S) ratios of uptake, and a sacro-iliac index (SI index) were calculated. High SI/S ratios and high SI indices were obtained in 15 patients with grades 0–2 sacro-iliac radiographs. Nine of these patients had clinically assessed ankylosing spondylitis (AS). Five patients with clinical AS, and grades 3 and 4 radiographs had normal SI indices. Quantitative scintigraphy appears to be useful in the diagnosis of early sacro-iliitis prior to the appearance of definite radiographic changes. Multilevel analysis, drug washout and background subtraction increase the sensitivity of the technique.</description><subject>Adult</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Radionuclide Imaging</subject><subject>Sacroiliac Joint - diagnostic imaging</subject><subject>Sacrum - diagnostic imaging</subject><subject>Spondylitis, Ankylosing - diagnostic imaging</subject><subject>Technetium</subject><issn>1462-0324</issn><issn>0300-3396</issn><issn>1462-0332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1OwkAUhSdGg4q-gSZduSvMXzudZVMLndiA0GKEzWRKp4oWi502kbe3BkJc3XvznXOSewC4Q3CAICfD-l23W9VUZfW2HyI-wAOXn4ErRF1sQ0Lw-WnH9BJcG_MBIXQQ8XqgxygkjPEr4M8W_iQVqZ-Kl9BKAtEd47n_HC0tMbHSKLRCfx4vrUfhjyfTRCTWdGQlfjCf2iIWIhXJDbgoVGn07XH2wWIUpkFkx9OxCPzYXhMKG1vluFCUMkVdVOSccSd3EVcuI0RnHqYFJ4zkrgMpywrPyzxdYAq5pogq6lBE-uDhkLurq-9Wm0ZuN2aty1J96ao1kjkYUUKcTkgPwnVdGVPrQu7qzVbVe4mg_GtO_m9OIi6xdHlnuz_mt9lW5yfTsaqO2we-MY3-OWFVf8ruCebI6HUlg_RptUIzKCPyCwTTdiQ</recordid><startdate>198005</startdate><enddate>198005</enddate><creator>DUNN, E. CAROLINE</creator><creator>EBRINGER, R. W.</creator><creator>ELL, P. J.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198005</creationdate><title>QUANTITATIVE SCINTIGRAPHY IN THE EARLY DIAGNOSIS OF SACRO-ILIITIS</title><author>DUNN, E. CAROLINE ; EBRINGER, R. W. ; ELL, P. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-ad2fa447a461fd9795d619a6733eb824f9373d65047bf88b8ef2409e414a45413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Adult</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Radionuclide Imaging</topic><topic>Sacroiliac Joint - diagnostic imaging</topic><topic>Sacrum - diagnostic imaging</topic><topic>Spondylitis, Ankylosing - diagnostic imaging</topic><topic>Technetium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DUNN, E. CAROLINE</creatorcontrib><creatorcontrib>EBRINGER, R. W.</creatorcontrib><creatorcontrib>ELL, P. J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DUNN, E. CAROLINE</au><au>EBRINGER, R. W.</au><au>ELL, P. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>QUANTITATIVE SCINTIGRAPHY IN THE EARLY DIAGNOSIS OF SACRO-ILIITIS</atitle><jtitle>Rheumatology (Oxford, England)</jtitle><addtitle>Rheumatol Rehabil</addtitle><date>1980-05</date><risdate>1980</risdate><volume>19</volume><issue>2</issue><spage>69</spage><epage>75</epage><pages>69-75</pages><issn>1462-0324</issn><issn>0300-3396</issn><eissn>1462-0332</eissn><abstract>SUMMARY Bone scans were performed on 65 subjects including 13 healthy controls and 52 patients aged over 20 years with suspected sacro-iliitis. Patients were given 15 mCi of technetium-99m methylene diphosphonate (99mTcMDP) intravenously and 400 K count images were recorded two hours later from the posterior pelvis and lower lumbar spine. Using a region of interest technique, counts were taken at three levels from each sacro-iliac joint and the central sacrum, and sacro-iliac/sacral (SI/S) ratios of uptake, and a sacro-iliac index (SI index) were calculated. High SI/S ratios and high SI indices were obtained in 15 patients with grades 0–2 sacro-iliac radiographs. Nine of these patients had clinically assessed ankylosing spondylitis (AS). Five patients with clinical AS, and grades 3 and 4 radiographs had normal SI indices. Quantitative scintigraphy appears to be useful in the diagnosis of early sacro-iliitis prior to the appearance of definite radiographic changes. Multilevel analysis, drug washout and background subtraction increase the sensitivity of the technique.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>7403779</pmid><doi>10.1093/rheumatology/19.2.69</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1462-0324 |
| ispartof | Rheumatology (Oxford, England), 1980-05, Vol.19 (2), p.69-75 |
| issn | 1462-0324 0300-3396 1462-0332 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adult Female Humans Male Middle Aged Radionuclide Imaging Sacroiliac Joint - diagnostic imaging Sacrum - diagnostic imaging Spondylitis, Ankylosing - diagnostic imaging Technetium |
| title | QUANTITATIVE SCINTIGRAPHY IN THE EARLY DIAGNOSIS OF SACRO-ILIITIS |
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