Distinctive sequence of human mitochondrial ribosomal RNA genes

The nucleotide sequence spanning the ribosomal RNA (rRNA) genes of cloned human mitochondrial DNA reveals an extremely compact genome organization wherein the putative tRNA genes are probably ‘butt-jointed’ around the two rRNA genes. The sequences of the rRNA genes are significantly homologous in so...

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Veröffentlicht in:Nature (London) 1980-07, Vol.286 (5772), p.460-467
Hauptverfasser: Eperon, I. C, Anderson, S, Nierlich, D. P
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Anderson, S
Nierlich, D. P
description The nucleotide sequence spanning the ribosomal RNA (rRNA) genes of cloned human mitochondrial DNA reveals an extremely compact genome organization wherein the putative tRNA genes are probably ‘butt-jointed’ around the two rRNA genes. The sequences of the rRNA genes are significantly homologous in some regions to eukaryotic and prokaryotic sequences, but distinctive ; the tRNA genes also have unusual nucleotide sequences. It seems that human mitochondria did not originate from recognizable relatives of present day organisms.
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subjects Base Sequence
Biological Evolution
Chromosome Mapping
DNA, Mitochondrial - genetics
Genes
Humanities and Social Sciences
Humans
Molecular Weight
multidisciplinary
RNA, Bacterial - genetics
RNA, Ribosomal - genetics
RNA, Transfer - genetics
Science
Science (multidisciplinary)
title Distinctive sequence of human mitochondrial ribosomal RNA genes
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