Distinctive sequence of human mitochondrial ribosomal RNA genes

The nucleotide sequence spanning the ribosomal RNA (rRNA) genes of cloned human mitochondrial DNA reveals an extremely compact genome organization wherein the putative tRNA genes are probably ‘butt-jointed’ around the two rRNA genes. The sequences of the rRNA genes are significantly homologous in so...

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Veröffentlicht in:	Nature (London) 1980-07, Vol.286 (5772), p.460-467
Hauptverfasser:	Eperon, I. C, Anderson, S, Nierlich, D. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological Evolution Chromosome Mapping DNA, Mitochondrial - genetics Genes Humanities and Social Sciences Humans Molecular Weight multidisciplinary RNA, Bacterial - genetics RNA, Ribosomal - genetics RNA, Transfer - genetics Science Science (multidisciplinary)
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Zusammenfassung:	The nucleotide sequence spanning the ribosomal RNA (rRNA) genes of cloned human mitochondrial DNA reveals an extremely compact genome organization wherein the putative tRNA genes are probably ‘butt-jointed’ around the two rRNA genes. The sequences of the rRNA genes are significantly homologous in some regions to eukaryotic and prokaryotic sequences, but distinctive ; the tRNA genes also have unusual nucleotide sequences. It seems that human mitochondria did not originate from recognizable relatives of present day organisms.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/286460a0