Inhibitor of angiotensin I converting enzyme: (4R)-3-[(2S)-3-mercapto-2-methylpropanoyl]-4-thiazolidinecarboxylic acid (YS-980)

Pharmacological studies on a new angiotensin I converting enzyme (ACE) inhibitor (4R)-3-[(2S)-3-mercapto-2-methylpropanoyl]-4-thiazolidinecarboxylic acid (YS-980), were carried out in vitro and in vivo. The activity of ACE prepared from rabbit lung by DEAE-Sepharose chromatography was determined usi...

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Veröffentlicht in:	Biochemical pharmacology 1980-06, Vol.29 (11), p.1543-1547
Hauptverfasser:	Yoshihiko, Funae, Tadamitsu, Komori, Daizo, Sasaki, Kenjiro, Yamamoto
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Mercaptopropionic Acid - analogs & derivatives 3-Mercaptopropionic Acid - pharmacology Angiotensin I - pharmacology Angiotensin II - pharmacology Angiotensin-Converting Enzyme Inhibitors Animals Blood Pressure - drug effects In Vitro Techniques Kinetics Norepinephrine - pharmacology Pentobarbital - pharmacology Pentolinium Tartrate - pharmacology Rabbits Renin - metabolism Sulfhydryl Compounds Thiazoles - pharmacology Thiazolidines
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