The assembly and properties of protobiological structures: The beginnings of cellular peptide synthesis

The assembly and properties of protobiological structures: The beginnings of cellular peptide synthesis

New data indicate that lysine-rich proteinoids have the ability to catalyze the synthesis of peptide bonds from a variety of amino acids and ATP. This capacity is evident in aqueous solution, in suspension of phase-separated complexes of lysine-rich proteinoid with acidic proteinoids, and in suspens...

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Veröffentlicht in:BioSystems 1980, Vol.12 (3), p.155-166
Hauptverfasser: Fox, Sidney W., Nakashima, Tadayoshi
Format: Artikel
Sprache:eng
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Adenosine Triphosphate
Peptide Biosynthesis
Peptides - chemical synthesis
Space life sciences
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container_title BioSystems
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creator Fox, Sidney W.
Nakashima, Tadayoshi
description New data indicate that lysine-rich proteinoids have the ability to catalyze the synthesis of peptide bonds from a variety of amino acids and ATP. This capacity is evident in aqueous solution, in suspension of phase-separated complexes of lysine-rich proteinoid with acidic proteinoids, and in suspension of phase-separated particles composed of lysine-rich proteinoids with polynucleotides. Since the proteinoid complexes can contain other catalytic activities, including ability to catalyze internucleotide bond formation, we infer that the first protocells on Earth already had a number of biological types of activity.
doi_str_mv 10.1016/0303-2647(80)90013-1
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subjects Adenosine Triphosphate
Peptide Biosynthesis
Peptides - chemical synthesis
Space life sciences
title The assembly and properties of protobiological structures: The beginnings of cellular peptide synthesis
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