Depressant and excitant effects of intraspinal microinjections of morphine and methionine-enkephalin in the cat
The effects of intraspinal microinjections of morphine (10 μg) and methionine-enkephalin (Met-enkephalin) (5 μg) on the C-fiber and polysynaptic reflexes in the acute decerebrate low spinal cat were investigated. Microinjected into the dorsal horn, morphine and Met-enkephalin depressed the nocicepti...
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| Veröffentlicht in: | Brain research 1980-09, Vol.196 (2), p.455-465 |
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| creator | Bell, James A. Sharpe, Lawrence G. Berry, James N. |
| description | The effects of intraspinal microinjections of morphine (10 μg) and methionine-enkephalin (Met-enkephalin) (5 μg) on the C-fiber and polysynaptic reflexes in the acute decerebrate low spinal cat were investigated. Microinjected into the dorsal horn, morphine and Met-enkephalin depressed the nociceptive C-fiber reflex (CFR) without altering the short latency polysynaptic reflex. Microinjected into the ventral horn, morphine and Met-enkephalin facilitated the C-fiber and polysynaptic reflexes. Pretreatment of the cats with intravenous naltrexone (2 mg/kg) antagonized the depressant effects produced by dorsal horn intraspinal microinjections of morphine and Met-enkephalin. The excitant effects of ventral horn microinjections of morphine were not antagonized by naltrexone (2 mg/kg). These results support a hypothesis that the analgesic effects of morphine at the spinal cord level are due to interactions with opiate receptors in the dorsal horn. |
| doi_str_mv | 10.1016/0006-8993(80)90409-6 |
| format | Article |
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Microinjected into the dorsal horn, morphine and Met-enkephalin depressed the nociceptive C-fiber reflex (CFR) without altering the short latency polysynaptic reflex. Microinjected into the ventral horn, morphine and Met-enkephalin facilitated the C-fiber and polysynaptic reflexes. Pretreatment of the cats with intravenous naltrexone (2 mg/kg) antagonized the depressant effects produced by dorsal horn intraspinal microinjections of morphine and Met-enkephalin. The excitant effects of ventral horn microinjections of morphine were not antagonized by naltrexone (2 mg/kg). These results support a hypothesis that the analgesic effects of morphine at the spinal cord level are due to interactions with opiate receptors in the dorsal horn.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(80)90409-6</identifier><identifier>PMID: 6249450</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; C-fiber reflex ; Cats ; Endorphins - pharmacology ; Enkephalins - pharmacology ; Evoked Potentials - drug effects ; Female ; Ganglia, Spinal - drug effects ; intraspinal microinjection ; Male ; Met-enkephalin ; morphine ; Morphine - pharmacology ; Motor Neurons - drug effects ; Naltrexone - pharmacology ; Nerve Fibers - drug effects ; nociceptive reflex ; Nociceptors - drug effects ; Reflex - drug effects ; Spinal Cord - drug effects ; Synapses - drug effects ; Synaptic Transmission - drug effects</subject><ispartof>Brain research, 1980-09, Vol.196 (2), p.455-465</ispartof><rights>1980 Elsevier/North-Holland Biomedical Press, Amsterdam</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-5c177e7703dfff33d140dce0732bd3c2270c8c51fa01bd3f3be485ac64930c423</citedby><cites>FETCH-LOGICAL-c338t-5c177e7703dfff33d140dce0732bd3c2270c8c51fa01bd3f3be485ac64930c423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(80)90409-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6249450$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bell, James A.</creatorcontrib><creatorcontrib>Sharpe, Lawrence G.</creatorcontrib><creatorcontrib>Berry, James N.</creatorcontrib><title>Depressant and excitant effects of intraspinal microinjections of morphine and methionine-enkephalin in the cat</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The effects of intraspinal microinjections of morphine (10 μg) and methionine-enkephalin (Met-enkephalin) (5 μg) on the C-fiber and polysynaptic reflexes in the acute decerebrate low spinal cat were investigated. Microinjected into the dorsal horn, morphine and Met-enkephalin depressed the nociceptive C-fiber reflex (CFR) without altering the short latency polysynaptic reflex. Microinjected into the ventral horn, morphine and Met-enkephalin facilitated the C-fiber and polysynaptic reflexes. Pretreatment of the cats with intravenous naltrexone (2 mg/kg) antagonized the depressant effects produced by dorsal horn intraspinal microinjections of morphine and Met-enkephalin. The excitant effects of ventral horn microinjections of morphine were not antagonized by naltrexone (2 mg/kg). These results support a hypothesis that the analgesic effects of morphine at the spinal cord level are due to interactions with opiate receptors in the dorsal horn.</description><subject>Animals</subject><subject>C-fiber reflex</subject><subject>Cats</subject><subject>Endorphins - pharmacology</subject><subject>Enkephalins - pharmacology</subject><subject>Evoked Potentials - drug effects</subject><subject>Female</subject><subject>Ganglia, Spinal - drug effects</subject><subject>intraspinal microinjection</subject><subject>Male</subject><subject>Met-enkephalin</subject><subject>morphine</subject><subject>Morphine - pharmacology</subject><subject>Motor Neurons - drug effects</subject><subject>Naltrexone - pharmacology</subject><subject>Nerve Fibers - drug effects</subject><subject>nociceptive reflex</subject><subject>Nociceptors - drug effects</subject><subject>Reflex - drug effects</subject><subject>Spinal Cord - drug effects</subject><subject>Synapses - drug effects</subject><subject>Synaptic Transmission - drug effects</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMo4_j4BwpdiS6qN03aphtBfMOAG12HTHrDRNu0JhnRf2_mgUtX4eSccy_3I-SEwiUFWl0BQJWLpmHnAi4a4NDk1Q6ZUlEXeVVw2CXTv8g-OQjhPUnGGpiQSfIbXsKUDHc4egxBuZgp12b4rW1cCTQGdQzZYDLroldhtE51WW-1H6x7T54d3NruBz8urMN1v8e4SEaSOboPHBeqsy5NyOICM63iEdkzqgt4vH0PydvD_evtUz57eXy-vZnlmjER81LTusa6BtYaYxhrKYdWI9SsmLdMF0UNWuiSGgU0fRg2Ry5KpSveMNC8YIfkbDN39MPnEkOUvQ0au045HJZB1iUVHESZgnwTTHeF4NHI0dte-R9JQa44yxVEuYIoBcg1Z1ml2ul2_nLeY_tX2oJN_vXGx3Tkl0Uvg7boNLbWJ3ayHez_C34B3EGOiw</recordid><startdate>19800908</startdate><enddate>19800908</enddate><creator>Bell, James A.</creator><creator>Sharpe, Lawrence G.</creator><creator>Berry, James N.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19800908</creationdate><title>Depressant and excitant effects of intraspinal microinjections of morphine and methionine-enkephalin in the cat</title><author>Bell, James A. ; Sharpe, Lawrence G. ; Berry, James N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-5c177e7703dfff33d140dce0732bd3c2270c8c51fa01bd3f3be485ac64930c423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>C-fiber reflex</topic><topic>Cats</topic><topic>Endorphins - pharmacology</topic><topic>Enkephalins - pharmacology</topic><topic>Evoked Potentials - drug effects</topic><topic>Female</topic><topic>Ganglia, Spinal - drug effects</topic><topic>intraspinal microinjection</topic><topic>Male</topic><topic>Met-enkephalin</topic><topic>morphine</topic><topic>Morphine - pharmacology</topic><topic>Motor Neurons - drug effects</topic><topic>Naltrexone - pharmacology</topic><topic>Nerve Fibers - drug effects</topic><topic>nociceptive reflex</topic><topic>Nociceptors - drug effects</topic><topic>Reflex - drug effects</topic><topic>Spinal Cord - drug effects</topic><topic>Synapses - drug effects</topic><topic>Synaptic Transmission - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bell, James A.</creatorcontrib><creatorcontrib>Sharpe, Lawrence G.</creatorcontrib><creatorcontrib>Berry, James N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bell, James A.</au><au>Sharpe, Lawrence G.</au><au>Berry, James N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depressant and excitant effects of intraspinal microinjections of morphine and methionine-enkephalin in the cat</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1980-09-08</date><risdate>1980</risdate><volume>196</volume><issue>2</issue><spage>455</spage><epage>465</epage><pages>455-465</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>The effects of intraspinal microinjections of morphine (10 μg) and methionine-enkephalin (Met-enkephalin) (5 μg) on the C-fiber and polysynaptic reflexes in the acute decerebrate low spinal cat were investigated. Microinjected into the dorsal horn, morphine and Met-enkephalin depressed the nociceptive C-fiber reflex (CFR) without altering the short latency polysynaptic reflex. Microinjected into the ventral horn, morphine and Met-enkephalin facilitated the C-fiber and polysynaptic reflexes. Pretreatment of the cats with intravenous naltrexone (2 mg/kg) antagonized the depressant effects produced by dorsal horn intraspinal microinjections of morphine and Met-enkephalin. The excitant effects of ventral horn microinjections of morphine were not antagonized by naltrexone (2 mg/kg). These results support a hypothesis that the analgesic effects of morphine at the spinal cord level are due to interactions with opiate receptors in the dorsal horn.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>6249450</pmid><doi>10.1016/0006-8993(80)90409-6</doi><tpages>11</tpages></addata></record> |
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| ispartof | Brain research, 1980-09, Vol.196 (2), p.455-465 |
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| subjects | Animals C-fiber reflex Cats Endorphins - pharmacology Enkephalins - pharmacology Evoked Potentials - drug effects Female Ganglia, Spinal - drug effects intraspinal microinjection Male Met-enkephalin morphine Morphine - pharmacology Motor Neurons - drug effects Naltrexone - pharmacology Nerve Fibers - drug effects nociceptive reflex Nociceptors - drug effects Reflex - drug effects Spinal Cord - drug effects Synapses - drug effects Synaptic Transmission - drug effects |
| title | Depressant and excitant effects of intraspinal microinjections of morphine and methionine-enkephalin in the cat |
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