The development and use of radiolabeled antitumor antibodies
The use of radioactive tumor-localizing antibodies is developed historically, starting with the demonstration that antibodies can be radioiodinated without destroying antibody activity. Then, antibodies against normal organs were shown to contain antibodies which localize in the normal organ. Subseq...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1980-08, Vol.40 (8 Pt 2), p.2960-2964 |
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| container_end_page | 2964 |
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| container_issue | 8 Pt 2 |
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| container_title | Cancer research (Chicago, Ill.) |
| container_volume | 40 |
| creator | Pressman, D |
| description | The use of radioactive tumor-localizing antibodies is developed historically, starting with the demonstration that antibodies can be radioiodinated without destroying antibody activity. Then, antibodies against normal organs were shown to contain antibodies which localize in the normal organ. Subsequently, antibodies capable of localizing in tumors were demonstrated, and these localized well enough to permit their use diagnostically by scanning for radioactivity and their use therapeutically by localizing sufficient radioiodine. Various relevant problems are discussed. |
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Then, antibodies against normal organs were shown to contain antibodies which localize in the normal organ. Subsequently, antibodies capable of localizing in tumors were demonstrated, and these localized well enough to permit their use diagnostically by scanning for radioactivity and their use therapeutically by localizing sufficient radioiodine. 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| ispartof | Cancer research (Chicago, Ill.), 1980-08, Vol.40 (8 Pt 2), p.2960-2964 |
| issn | 0008-5472 |
| language | eng |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antibodies, Neoplasm - immunology History of medicine History, 19th Century History, 20th Century Humans Immunologic Techniques - history Injections, Intravenous Iodine Radioisotopes Isotope Labeling - methods Neoplasms - diagnostic imaging Neoplasms - immunology Radionuclide Imaging |
| title | The development and use of radiolabeled antitumor antibodies |
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