Differential fornix ablations and the circadian rhythmicity of adrenal corticosteroid secretion
Suction ablations of the medial or lateral fornix were performed in order to transect selectively the medial corticohypothalamic tract (mcht) which originates in the anteroventral subiculum and travels in the lateral fornix terminating in the basal hypothalamus. The circadian rhythmicity of plasma a...
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| Veröffentlicht in: | Brain research 1980-08, Vol.195 (2), p.373-387 |
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| creator | Fischette, Christine T. Komisaruk, Barry R. Edinger, Henry M. Feder, Harvey H. Siegel, Allan |
| description | Suction ablations of the medial or lateral fornix were performed in order to transect selectively the medial corticohypothalamic tract (mcht) which originates in the anteroventral subiculum and travels in the lateral fornix terminating in the basal hypothalamus. The circadian rhythmicity of plasma adrenal corticosteroid levels was assessed in individual animals 1–2 weeks postoperatively. Ablation of the lateral fornix disrupted the periodicity of corticosteroid secretion which is normally synchronized with the light-dark cycle, whereas medial fornix ablation or neocortical ablation caused no such disruption. Group mean levels of plasma adrenal corticoids were higher in the lateral fornix-ablated animals than in the medial fornix-ablated, neocortically ablated, or intact control animals. These findings suggest that the anteroventral subiculum is important in the regulation of adrenal corticosteroid rhythmicity, and that it exerts an inhibitory influence upon corticosteroid release. |
| doi_str_mv | 10.1016/0006-8993(80)90073-6 |
| format | Article |
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The circadian rhythmicity of plasma adrenal corticosteroid levels was assessed in individual animals 1–2 weeks postoperatively. Ablation of the lateral fornix disrupted the periodicity of corticosteroid secretion which is normally synchronized with the light-dark cycle, whereas medial fornix ablation or neocortical ablation caused no such disruption. Group mean levels of plasma adrenal corticoids were higher in the lateral fornix-ablated animals than in the medial fornix-ablated, neocortically ablated, or intact control animals. 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The circadian rhythmicity of plasma adrenal corticosteroid levels was assessed in individual animals 1–2 weeks postoperatively. Ablation of the lateral fornix disrupted the periodicity of corticosteroid secretion which is normally synchronized with the light-dark cycle, whereas medial fornix ablation or neocortical ablation caused no such disruption. Group mean levels of plasma adrenal corticoids were higher in the lateral fornix-ablated animals than in the medial fornix-ablated, neocortically ablated, or intact control animals. These findings suggest that the anteroventral subiculum is important in the regulation of adrenal corticosteroid rhythmicity, and that it exerts an inhibitory influence upon corticosteroid release.</description><subject>Adrenal Cortex Hormones - blood</subject><subject>Afferent Pathways - physiology</subject><subject>Animals</subject><subject>Cerebral Cortex - physiology</subject><subject>Circadian Rhythm</subject><subject>circadian rhythms</subject><subject>corticosterone</subject><subject>fornix</subject><subject>hippocampal formation</subject><subject>Hippocampus - physiology</subject><subject>Hypothalamus - physiology</subject><subject>Male</subject><subject>Neural Inhibition</subject><subject>Optic Chiasm - physiology</subject><subject>Rats</subject><subject>subiculum</subject><subject>suprachiasmatic nucleus</subject><subject>Supraoptic Nucleus - physiology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpSDdp_0ELOpXm4GRs2ZJ1KZQ0XxDIJXcxHo9YFa-VStqS_ff1dpccexqG92OYR4jPNVzWUOsrANBVb6361sOFBTCq0u_Equ5NU-mmhfdi9Wb5IM5y_rWsSlk4FadGWdOBWQn3M3jPiecScJI-pjm8ShwmLCHOWeI8yrJmSSERjgFnmda7st4ECmUno5c4LtklSTGVQDEXTjGMMjMl3ld8FCcep8yfjvNcPN_ePF_fV49Pdw_XPx4rahtVqg704JFIeTYNmqGtB4LGcKNwhBp9j9oMyAhgbdsOTNaTUZo7Tdp3Vp2Lr4falxR_bzkXtwmZeJpw5rjNznR1r0B3i7E9GCnFnBN795LCBtPO1eD2WN2emdszcz24f1idXmJfjv3bYcPjW-jIcdG_H3RefvwTOLlMgWfiMSSm4sYY_n_gLzGSiX8</recordid><startdate>19800818</startdate><enddate>19800818</enddate><creator>Fischette, Christine T.</creator><creator>Komisaruk, Barry R.</creator><creator>Edinger, Henry M.</creator><creator>Feder, Harvey H.</creator><creator>Siegel, Allan</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19800818</creationdate><title>Differential fornix ablations and the circadian rhythmicity of adrenal corticosteroid secretion</title><author>Fischette, Christine T. ; Komisaruk, Barry R. ; Edinger, Henry M. ; Feder, Harvey H. ; Siegel, Allan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-506bfacc3fe72a7b41bc027e23ad01af8a67baea009944bec9fc736e56c6f593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Adrenal Cortex Hormones - blood</topic><topic>Afferent Pathways - physiology</topic><topic>Animals</topic><topic>Cerebral Cortex - physiology</topic><topic>Circadian Rhythm</topic><topic>circadian rhythms</topic><topic>corticosterone</topic><topic>fornix</topic><topic>hippocampal formation</topic><topic>Hippocampus - physiology</topic><topic>Hypothalamus - physiology</topic><topic>Male</topic><topic>Neural Inhibition</topic><topic>Optic Chiasm - physiology</topic><topic>Rats</topic><topic>subiculum</topic><topic>suprachiasmatic nucleus</topic><topic>Supraoptic Nucleus - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fischette, Christine T.</creatorcontrib><creatorcontrib>Komisaruk, Barry R.</creatorcontrib><creatorcontrib>Edinger, Henry M.</creatorcontrib><creatorcontrib>Feder, Harvey H.</creatorcontrib><creatorcontrib>Siegel, Allan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fischette, Christine T.</au><au>Komisaruk, Barry R.</au><au>Edinger, Henry M.</au><au>Feder, Harvey H.</au><au>Siegel, Allan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential fornix ablations and the circadian rhythmicity of adrenal corticosteroid secretion</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1980-08-18</date><risdate>1980</risdate><volume>195</volume><issue>2</issue><spage>373</spage><epage>387</epage><pages>373-387</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Suction ablations of the medial or lateral fornix were performed in order to transect selectively the medial corticohypothalamic tract (mcht) which originates in the anteroventral subiculum and travels in the lateral fornix terminating in the basal hypothalamus. The circadian rhythmicity of plasma adrenal corticosteroid levels was assessed in individual animals 1–2 weeks postoperatively. Ablation of the lateral fornix disrupted the periodicity of corticosteroid secretion which is normally synchronized with the light-dark cycle, whereas medial fornix ablation or neocortical ablation caused no such disruption. Group mean levels of plasma adrenal corticoids were higher in the lateral fornix-ablated animals than in the medial fornix-ablated, neocortically ablated, or intact control animals. These findings suggest that the anteroventral subiculum is important in the regulation of adrenal corticosteroid rhythmicity, and that it exerts an inhibitory influence upon corticosteroid release.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>7397507</pmid><doi>10.1016/0006-8993(80)90073-6</doi><tpages>15</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adrenal Cortex Hormones - blood Afferent Pathways - physiology Animals Cerebral Cortex - physiology Circadian Rhythm circadian rhythms corticosterone fornix hippocampal formation Hippocampus - physiology Hypothalamus - physiology Male Neural Inhibition Optic Chiasm - physiology Rats subiculum suprachiasmatic nucleus Supraoptic Nucleus - physiology |
| title | Differential fornix ablations and the circadian rhythmicity of adrenal corticosteroid secretion |
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