Biochemical Analysis of Human T Lymphocyte Differentiation Antigens T4 and T5

Two major functionally distinct T cell subsets in man have been defined with heteroantiserums and monoclonal antibodies directed against stable cell surface antigens that appear during thymic ontogeny. A monoclonal antibody to T4 antigen (anti-T4) is reactive with the peripheral inducer T cell popul...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1980-07, Vol.209 (4455), p.520-521
Hauptverfasser: Terhorst, Cox, Van Agthoven, Andre, Reinherz, Ellis, Schlossman, Stuart
Format: Artikel
Sprache:eng
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Zusammenfassung:Two major functionally distinct T cell subsets in man have been defined with heteroantiserums and monoclonal antibodies directed against stable cell surface antigens that appear during thymic ontogeny. A monoclonal antibody to T4 antigen (anti-T4) is reactive with the peripheral inducer T cell population while a monoclonal antibody to T5 antigen (anti-T5) is reactive with the cytotoxic and suppressor population. Immunoprecipitation and electrophoresis on sodium dodecyl sulfate polyacrylamide gel were used to show that on human thymocytes or peripheral T cells the T4 antigen is a single 62,000-dalton glycoprotein while the T5 antigen is a complex of two glycoproteins, one being 30,000 daltons and the other 32,000 daltons. Similar glycoproteins have been isolated with antibodies to murine Lyt 1 and Lyt 2,3 antigens. Both the antigens defining the phenotypes of inducer and suppressor populations in man and mouse are structurally homologous.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6967228