Metabolism of Lidocaine in Human Liver in Vitro

: We have incubated the local anaesthetic drug lidocaine with microsomes from human adult livers. The metabolites deethylated lidocaine (MEGX) and aromatically hydroxylated lidocaine (3‐hydroxylidocaine) were isolated by high performance liquid chromatography and quantitated by the liquid scintillat...

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Veröffentlicht in:	Acta pharmacologica et toxicologica 1980-07, Vol.47 (1), p.49-52
Hauptverfasser:	Hermansson, Jørgen, Glaumann, Hans, Karlén, Bo, Bahr, Christer
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Chromatography, High Pressure Liquid Cytochrome P-450 Enzyme System - metabolism cytochrome P‐450 Dealkylation Drug metabolism Female human liver microsomes Humans Hydroxylation lidocaine Lidocaine - metabolism Male Microsomes, Liver - metabolism Middle Aged species differences Species Specificity
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