Effect of Silica on the Proliferative Behavior of Human Lung Fibroblasts
We show that silica enhances the proliferation of some but not all lung derived fibroblastlike cells (FLC) of fetal and adult origin. Cultures were obtained from lung biopsy and lavage of normal individuals and patients with interstitial lung disease. The responses of these cell lines were heterogen...
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| Veröffentlicht in: | In Vitro 1980-05, Vol.16 (5), p.371-376 |
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| container_title | In Vitro |
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| creator | Absher, M Mortara, M |
| description | We show that silica enhances the proliferation of some but not all lung derived fibroblastlike cells (FLC) of fetal and adult origin. Cultures were obtained from lung biopsy and lavage of normal individuals and patients with interstitial lung disease. The responses of these cell lines were heterogeneous; some cultures were stimulated to proliferate in the presence of silica and others were not stimulated. There was no apparent correlation between source of the cell lines and the effects of silica. The proliferative capacity of the cells appeared to be an important determinant of the effect of silica on the growth of the cultures. |
| doi_str_mv | 10.1007/BF02618359 |
| format | Article |
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Cultures were obtained from lung biopsy and lavage of normal individuals and patients with interstitial lung disease. The responses of these cell lines were heterogeneous; some cultures were stimulated to proliferate in the presence of silica and others were not stimulated. There was no apparent correlation between source of the cell lines and the effects of silica. The proliferative capacity of the cells appeared to be an important determinant of the effect of silica on the growth of the cultures.</description><identifier>ISSN: 0073-5655</identifier><identifier>EISSN: 1475-2689</identifier><identifier>DOI: 10.1007/BF02618359</identifier><identifier>PMID: 6248451</identifier><language>eng</language><publisher>United States: Tissue Culture Association, Inc</publisher><subject>Adult ; Adults ; Age ; Cell Division - drug effects ; Cell growth ; Cell Line ; Cell lines ; Cell Survival ; Cultured cells ; Diploidy ; Dose-Response Relationship, Drug ; Fibroblasts ; Fibroblasts - cytology ; Fibroblasts - drug effects ; Humans ; Lung - embryology ; Lungs ; Macrophages ; Silicon Dioxide - pharmacology ; Therapeutic irrigation</subject><ispartof>In Vitro, 1980-05, Vol.16 (5), p.371-376</ispartof><rights>Copyright 1980 Tissue Culture Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c303t-c9b80f620439c722ae10be023231f625d9af01eed4ca37fc2dc6f3f177c17d473</citedby><cites>FETCH-LOGICAL-c303t-c9b80f620439c722ae10be023231f625d9af01eed4ca37fc2dc6f3f177c17d473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4292353$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4292353$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6248451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Absher, M</creatorcontrib><creatorcontrib>Mortara, M</creatorcontrib><title>Effect of Silica on the Proliferative Behavior of Human Lung Fibroblasts</title><title>In Vitro</title><addtitle>In Vitro</addtitle><description>We show that silica enhances the proliferation of some but not all lung derived fibroblastlike cells (FLC) of fetal and adult origin. 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The proliferative capacity of the cells appeared to be an important determinant of the effect of silica on the growth of the cultures.</description><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Cell Division - drug effects</subject><subject>Cell growth</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Cell Survival</subject><subject>Cultured cells</subject><subject>Diploidy</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fibroblasts</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - drug effects</subject><subject>Humans</subject><subject>Lung - embryology</subject><subject>Lungs</subject><subject>Macrophages</subject><subject>Silicon Dioxide - pharmacology</subject><subject>Therapeutic irrigation</subject><issn>0073-5655</issn><issn>1475-2689</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LwzAYh4Moc04vnhVy8iBU85326MbmhIGCei5pmriMttEkHfjf27ExTy-8z8Pv8ABwjdEDRkg-TheICJxTXpyAMWaSZ0TkxSkYD5BmXHB-Di5i3CBEkSB4BEaCsJxxPAbLubVGJ-gtfHeN0wr6Dqa1gW_BN86aoJLbGjg1a7V1Puy8Zd-qDq767gsuXBV81aiY4iU4s6qJ5upwJ-BzMf-YLbPV6_PL7GmVaYpoynRR5cgKghgttCREGYwqgwglFA9vXhfKImxMzbSi0mpSa2GpxVJqLGsm6QTc7Xe_g__pTUxl66I2TaM64_tYSo5FwTAbxPu9qIOPMRhbfgfXqvBbYlTuspX_2Qb59rDaV62pj-qh08Bv9nwTkw9HzEhBKKf0D9Ywb48</recordid><startdate>198005</startdate><enddate>198005</enddate><creator>Absher, M</creator><creator>Mortara, M</creator><general>Tissue Culture Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198005</creationdate><title>Effect of Silica on the Proliferative Behavior of Human Lung Fibroblasts</title><author>Absher, M ; Mortara, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-c9b80f620439c722ae10be023231f625d9af01eed4ca37fc2dc6f3f177c17d473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Age</topic><topic>Cell Division - drug effects</topic><topic>Cell growth</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Cell Survival</topic><topic>Cultured cells</topic><topic>Diploidy</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fibroblasts</topic><topic>Fibroblasts - cytology</topic><topic>Fibroblasts - drug effects</topic><topic>Humans</topic><topic>Lung - embryology</topic><topic>Lungs</topic><topic>Macrophages</topic><topic>Silicon Dioxide - pharmacology</topic><topic>Therapeutic irrigation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Absher, M</creatorcontrib><creatorcontrib>Mortara, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>In Vitro</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Absher, M</au><au>Mortara, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Silica on the Proliferative Behavior of Human Lung Fibroblasts</atitle><jtitle>In Vitro</jtitle><addtitle>In Vitro</addtitle><date>1980-05</date><risdate>1980</risdate><volume>16</volume><issue>5</issue><spage>371</spage><epage>376</epage><pages>371-376</pages><issn>0073-5655</issn><eissn>1475-2689</eissn><abstract>We show that silica enhances the proliferation of some but not all lung derived fibroblastlike cells (FLC) of fetal and adult origin. 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| fulltext | fulltext |
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| ispartof | In Vitro, 1980-05, Vol.16 (5), p.371-376 |
| issn | 0073-5655 1475-2689 |
| language | eng |
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| source | MEDLINE; JSTOR; SpringerLink Journals - AutoHoldings |
| subjects | Adult Adults Age Cell Division - drug effects Cell growth Cell Line Cell lines Cell Survival Cultured cells Diploidy Dose-Response Relationship, Drug Fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Humans Lung - embryology Lungs Macrophages Silicon Dioxide - pharmacology Therapeutic irrigation |
| title | Effect of Silica on the Proliferative Behavior of Human Lung Fibroblasts |
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