Enkephalin inactivation by N-terminal tyrosine cleavage: Purification and partial characterization of a highly specific enzyme from human brain

A soluble enzyme which rapidly degrades both Met and Leu-enkephalin by cleavage of the Tyr-Gly bond has been identified in homogenates of corpora striata from human brain. A marked preference for Met-enkephalin as substrate over Leu-enkephalin was observed. Tyr was not cleaved from other closely rel...

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Veröffentlicht in:	Life sciences (1973) 1980-05, Vol.26 (20), p.1697-1706
Hauptverfasser:	Traficante, Louis J., Rotrosen, John, Siekierski, Joanne, Tracer, Howard, Gershon, Samuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopeptidases - isolation & purification Aminopeptidases - metabolism Brain - enzymology Corpus Striatum - enzymology Electrophoresis, Polyacrylamide Gel Endorphins - metabolism Enkephalins - metabolism Humans Methionine - metabolism Molecular Weight Substrate Specificity Tyrosine - metabolism
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