Glycosaminoglycan metabolism following acute myocardial infarction and the effects of intravenous hyaluronidase therapy
A series of thirteen patients with acute myocardial infarction was studied. In the 12 patients heparinised on admission, there was a fall in serum hyaluronidase activity, free amino sugar and uronic acid levels. This contrasted with a rise in creatine kinase activity. In a single unheparinised patie...
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| Veröffentlicht in: | Clinical biochemistry 1980-04, Vol.13 (2), p.92-94 |
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| creator | Salkie, M.L. |
| description | A series of thirteen patients with acute myocardial infarction was studied. In the 12 patients heparinised on admission, there was a fall in serum hyaluronidase activity, free amino sugar and uronic acid levels. This contrasted with a rise in creatine kinase activity. In a single unheparinised patient, the hyaluronidase level rose. This suggests that necrotic cardiac tissue releases hyaluronidase. Any beneficial effects of the local release of hyaluronidase may be minimized by heparin therapy.
Study of patients on a trial of intravenous bovine testicular hyaluronidase following acute myocardial infarction could detect no rise in hyaluronidase levels. This confirms previous reports that human serum inhibits bovine testicular hyaluronidase. |
| doi_str_mv | 10.1016/S0009-9120(80)91263-1 |
| format | Article |
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Study of patients on a trial of intravenous bovine testicular hyaluronidase following acute myocardial infarction could detect no rise in hyaluronidase levels. This confirms previous reports that human serum inhibits bovine testicular hyaluronidase.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/S0009-9120(80)91263-1</identifier><identifier>PMID: 7389076</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Glycosaminoglycans - metabolism ; Heparin - therapeutic use ; Humans ; Hyaluronoglucosaminidase - blood ; Hyaluronoglucosaminidase - therapeutic use ; Myocardial Infarction - drug therapy ; Myocardial Infarction - metabolism</subject><ispartof>Clinical biochemistry, 1980-04, Vol.13 (2), p.92-94</ispartof><rights>1980 Technicon Instruments Corporation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-4b9b1a0b9aa425d1664d5118e140daaac44e49bffd745baa6a04118c9c0611093</citedby><cites>FETCH-LOGICAL-c360t-4b9b1a0b9aa425d1664d5118e140daaac44e49bffd745baa6a04118c9c0611093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009912080912631$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7389076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salkie, M.L.</creatorcontrib><title>Glycosaminoglycan metabolism following acute myocardial infarction and the effects of intravenous hyaluronidase therapy</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>A series of thirteen patients with acute myocardial infarction was studied. In the 12 patients heparinised on admission, there was a fall in serum hyaluronidase activity, free amino sugar and uronic acid levels. This contrasted with a rise in creatine kinase activity. In a single unheparinised patient, the hyaluronidase level rose. This suggests that necrotic cardiac tissue releases hyaluronidase. Any beneficial effects of the local release of hyaluronidase may be minimized by heparin therapy.
Study of patients on a trial of intravenous bovine testicular hyaluronidase following acute myocardial infarction could detect no rise in hyaluronidase levels. This confirms previous reports that human serum inhibits bovine testicular hyaluronidase.</description><subject>Glycosaminoglycans - metabolism</subject><subject>Heparin - therapeutic use</subject><subject>Humans</subject><subject>Hyaluronoglucosaminidase - blood</subject><subject>Hyaluronoglucosaminidase - therapeutic use</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Myocardial Infarction - metabolism</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EKkvhJ1TyCcEhYCeOE58QqqCtVIkDcLYm9rg1cuzFTlrl3-PtrnrlNDN63_l6CLng7BNnXH7-yRhTjeIt-zCyjzXKruEvyI6PQ9e0qutekt2z5TV5U8qfWrZilGfkbOhGxQa5I49XYTOpwOxjuqspRDrjAlMKvszUpRDSo493FMy6IJ23ZCBbD4H66CCbxadIIVq63CNF59AshSZX1SXDA8a0Fnq_QVhzit5CwYMxw357S145CAXfneI5-f3926_L6-b2x9XN5dfbxnSSLY2Y1MSBTQpAtL3lUgrbcz4iF8wCgBEChZqcs4PoJwAJTFTZKMMk50x15-T9ce4-p78rlkXPvhgMASLW4_TQc9m3jFVjfzSanErJ6PQ--xnypjnTB-D6Cbg-0NQj00_ANa99F6cF6zSjfe46Ea76l6OO9csHj1kX4zEatD5XWtom_58N_wBEm5Na</recordid><startdate>198004</startdate><enddate>198004</enddate><creator>Salkie, M.L.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198004</creationdate><title>Glycosaminoglycan metabolism following acute myocardial infarction and the effects of intravenous hyaluronidase therapy</title><author>Salkie, M.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-4b9b1a0b9aa425d1664d5118e140daaac44e49bffd745baa6a04118c9c0611093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Glycosaminoglycans - metabolism</topic><topic>Heparin - therapeutic use</topic><topic>Humans</topic><topic>Hyaluronoglucosaminidase - blood</topic><topic>Hyaluronoglucosaminidase - therapeutic use</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Myocardial Infarction - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salkie, M.L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salkie, M.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glycosaminoglycan metabolism following acute myocardial infarction and the effects of intravenous hyaluronidase therapy</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>1980-04</date><risdate>1980</risdate><volume>13</volume><issue>2</issue><spage>92</spage><epage>94</epage><pages>92-94</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>A series of thirteen patients with acute myocardial infarction was studied. In the 12 patients heparinised on admission, there was a fall in serum hyaluronidase activity, free amino sugar and uronic acid levels. This contrasted with a rise in creatine kinase activity. In a single unheparinised patient, the hyaluronidase level rose. This suggests that necrotic cardiac tissue releases hyaluronidase. Any beneficial effects of the local release of hyaluronidase may be minimized by heparin therapy.
Study of patients on a trial of intravenous bovine testicular hyaluronidase following acute myocardial infarction could detect no rise in hyaluronidase levels. This confirms previous reports that human serum inhibits bovine testicular hyaluronidase.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7389076</pmid><doi>10.1016/S0009-9120(80)91263-1</doi><tpages>3</tpages></addata></record> |
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| ispartof | Clinical biochemistry, 1980-04, Vol.13 (2), p.92-94 |
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| language | eng |
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| subjects | Glycosaminoglycans - metabolism Heparin - therapeutic use Humans Hyaluronoglucosaminidase - blood Hyaluronoglucosaminidase - therapeutic use Myocardial Infarction - drug therapy Myocardial Infarction - metabolism |
| title | Glycosaminoglycan metabolism following acute myocardial infarction and the effects of intravenous hyaluronidase therapy |
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