Synthesis of Granuliberin-R and Various Fragment Peptides and Their Histamine-Releasing Activities
Granuliberin-R and various fragment peptides were synthesized and their histaminereleasing activities were examined. The relative potencies of granuliberin-R, H-Phe-Gly-Phe-Leu-Pro-Ile-Tyr-Arg-Arg-Pro-Ala-Ser-NH2, as liberators of histamine from mast cells are very similar to those of substance P an...
Gespeichert in:
| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1980/03/25, Vol.28(3), pp.887-892 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 892 |
|---|---|
| container_issue | 3 |
| container_start_page | 887 |
| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 28 |
| creator | KITADA, CHIEKO ASHIDA, YASUKO MAKI, YOSHITAKA FUJINO, MASAHIKO HIRAI, YUKO YASUHARA, TADASHI NAKAJIMA, TERUMI TAKEYAMA, MASAHARU KOYAMA, KANAME YAJIMA, HARUAKI |
| description | Granuliberin-R and various fragment peptides were synthesized and their histaminereleasing activities were examined. The relative potencies of granuliberin-R, H-Phe-Gly-Phe-Leu-Pro-Ile-Tyr-Arg-Arg-Pro-Ala-Ser-NH2, as liberators of histamine from mast cells are very similar to those of substance P and bradykinin. Studies on the histamine-releasing activity of various fragment peptides of granuliberin-R showed that a 4-amino acid central sequence, -Ile-Tyr-Arg-Arg-, is the minimum requirement for the releasing action of this frog skin peptide. |
| doi_str_mv | 10.1248/cpb.28.887 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75163271</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3132030481</sourcerecordid><originalsourceid>FETCH-LOGICAL-c472t-a897a7e74521353923b35783dc6bd9e1bd9546be9a10334c611cd1a69d456033</originalsourceid><addsrcrecordid>eNpdkEtrGzEURkVJSZy0m-4LA4EsAuPqMXotg8mjEGhJTbdCo7m2ZWY0jqQJ-N9Xrk0K3dy7-A4f9x6EvhA8J7RR39yunVM1V0p-QDPCGllzStkZmmGMdU2ZYBfoMqUtxpRjyc7RuSBcYEpmqP21D3kDyadqXFWP0Yap9y1EH-qXyoau-m2jH6dUPUS7HiDk6ifssu8g_U2XG_CxevIp28EHqF-gB5t8WFd3Lvs3nz2kT-jjyvYJPp_2FVo-3C8XT_Xzj8fvi7vn2jWS5toqLa0E2XBKGGeaspZxqVjnRNtpIGXwRrSgLcGMNU4Q4jpihe6a8gtjV-jmWLuL4-sEKZvBJwd9bwOUB4zkRDAqSQGv_wO34xRDOc2QhmulBeayULdHysUxpQgrs4t-sHFvCDYH66ZYN1SZYr3AX0-VUztA946eNJd8ccy3RdQa3nMbs3c9HKqI5upQx46jtP5LNzYaCOwPFJmUIg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1459896057</pqid></control><display><type>article</type><title>Synthesis of Granuliberin-R and Various Fragment Peptides and Their Histamine-Releasing Activities</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>Free Full-Text Journals in Chemistry</source><creator>KITADA, CHIEKO ; ASHIDA, YASUKO ; MAKI, YOSHITAKA ; FUJINO, MASAHIKO ; HIRAI, YUKO ; YASUHARA, TADASHI ; NAKAJIMA, TERUMI ; TAKEYAMA, MASAHARU ; KOYAMA, KANAME ; YAJIMA, HARUAKI</creator><creatorcontrib>KITADA, CHIEKO ; ASHIDA, YASUKO ; MAKI, YOSHITAKA ; FUJINO, MASAHIKO ; HIRAI, YUKO ; YASUHARA, TADASHI ; NAKAJIMA, TERUMI ; TAKEYAMA, MASAHARU ; KOYAMA, KANAME ; YAJIMA, HARUAKI</creatorcontrib><description>Granuliberin-R and various fragment peptides were synthesized and their histaminereleasing activities were examined. The relative potencies of granuliberin-R, H-Phe-Gly-Phe-Leu-Pro-Ile-Tyr-Arg-Arg-Pro-Ala-Ser-NH2, as liberators of histamine from mast cells are very similar to those of substance P and bradykinin. Studies on the histamine-releasing activity of various fragment peptides of granuliberin-R showed that a 4-amino acid central sequence, -Ile-Tyr-Arg-Arg-, is the minimum requirement for the releasing action of this frog skin peptide.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.28.887</identifier><identifier>PMID: 6156021</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Cytoplasmic Granules - drug effects ; fragment peptides of granuliberin-R ; Histamine Release - drug effects ; In Vitro Techniques ; Mast Cells - drug effects ; Oligopeptides - chemical synthesis ; Oligopeptides - pharmacology ; Peptide Fragments - chemical synthesis ; Peptide Fragments - pharmacology ; Rats</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1980/03/25, Vol.28(3), pp.887-892</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 1980</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-a897a7e74521353923b35783dc6bd9e1bd9546be9a10334c611cd1a69d456033</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6156021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KITADA, CHIEKO</creatorcontrib><creatorcontrib>ASHIDA, YASUKO</creatorcontrib><creatorcontrib>MAKI, YOSHITAKA</creatorcontrib><creatorcontrib>FUJINO, MASAHIKO</creatorcontrib><creatorcontrib>HIRAI, YUKO</creatorcontrib><creatorcontrib>YASUHARA, TADASHI</creatorcontrib><creatorcontrib>NAKAJIMA, TERUMI</creatorcontrib><creatorcontrib>TAKEYAMA, MASAHARU</creatorcontrib><creatorcontrib>KOYAMA, KANAME</creatorcontrib><creatorcontrib>YAJIMA, HARUAKI</creatorcontrib><title>Synthesis of Granuliberin-R and Various Fragment Peptides and Their Histamine-Releasing Activities</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Granuliberin-R and various fragment peptides were synthesized and their histaminereleasing activities were examined. The relative potencies of granuliberin-R, H-Phe-Gly-Phe-Leu-Pro-Ile-Tyr-Arg-Arg-Pro-Ala-Ser-NH2, as liberators of histamine from mast cells are very similar to those of substance P and bradykinin. Studies on the histamine-releasing activity of various fragment peptides of granuliberin-R showed that a 4-amino acid central sequence, -Ile-Tyr-Arg-Arg-, is the minimum requirement for the releasing action of this frog skin peptide.</description><subject>Animals</subject><subject>Cytoplasmic Granules - drug effects</subject><subject>fragment peptides of granuliberin-R</subject><subject>Histamine Release - drug effects</subject><subject>In Vitro Techniques</subject><subject>Mast Cells - drug effects</subject><subject>Oligopeptides - chemical synthesis</subject><subject>Oligopeptides - pharmacology</subject><subject>Peptide Fragments - chemical synthesis</subject><subject>Peptide Fragments - pharmacology</subject><subject>Rats</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtrGzEURkVJSZy0m-4LA4EsAuPqMXotg8mjEGhJTbdCo7m2ZWY0jqQJ-N9Xrk0K3dy7-A4f9x6EvhA8J7RR39yunVM1V0p-QDPCGllzStkZmmGMdU2ZYBfoMqUtxpRjyc7RuSBcYEpmqP21D3kDyadqXFWP0Yap9y1EH-qXyoau-m2jH6dUPUS7HiDk6ifssu8g_U2XG_CxevIp28EHqF-gB5t8WFd3Lvs3nz2kT-jjyvYJPp_2FVo-3C8XT_Xzj8fvi7vn2jWS5toqLa0E2XBKGGeaspZxqVjnRNtpIGXwRrSgLcGMNU4Q4jpihe6a8gtjV-jmWLuL4-sEKZvBJwd9bwOUB4zkRDAqSQGv_wO34xRDOc2QhmulBeayULdHysUxpQgrs4t-sHFvCDYH66ZYN1SZYr3AX0-VUztA946eNJd8ccy3RdQa3nMbs3c9HKqI5upQx46jtP5LNzYaCOwPFJmUIg</recordid><startdate>19800101</startdate><enddate>19800101</enddate><creator>KITADA, CHIEKO</creator><creator>ASHIDA, YASUKO</creator><creator>MAKI, YOSHITAKA</creator><creator>FUJINO, MASAHIKO</creator><creator>HIRAI, YUKO</creator><creator>YASUHARA, TADASHI</creator><creator>NAKAJIMA, TERUMI</creator><creator>TAKEYAMA, MASAHARU</creator><creator>KOYAMA, KANAME</creator><creator>YAJIMA, HARUAKI</creator><general>The Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19800101</creationdate><title>Synthesis of Granuliberin-R and Various Fragment Peptides and Their Histamine-Releasing Activities</title><author>KITADA, CHIEKO ; ASHIDA, YASUKO ; MAKI, YOSHITAKA ; FUJINO, MASAHIKO ; HIRAI, YUKO ; YASUHARA, TADASHI ; NAKAJIMA, TERUMI ; TAKEYAMA, MASAHARU ; KOYAMA, KANAME ; YAJIMA, HARUAKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-a897a7e74521353923b35783dc6bd9e1bd9546be9a10334c611cd1a69d456033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Cytoplasmic Granules - drug effects</topic><topic>fragment peptides of granuliberin-R</topic><topic>Histamine Release - drug effects</topic><topic>In Vitro Techniques</topic><topic>Mast Cells - drug effects</topic><topic>Oligopeptides - chemical synthesis</topic><topic>Oligopeptides - pharmacology</topic><topic>Peptide Fragments - chemical synthesis</topic><topic>Peptide Fragments - pharmacology</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KITADA, CHIEKO</creatorcontrib><creatorcontrib>ASHIDA, YASUKO</creatorcontrib><creatorcontrib>MAKI, YOSHITAKA</creatorcontrib><creatorcontrib>FUJINO, MASAHIKO</creatorcontrib><creatorcontrib>HIRAI, YUKO</creatorcontrib><creatorcontrib>YASUHARA, TADASHI</creatorcontrib><creatorcontrib>NAKAJIMA, TERUMI</creatorcontrib><creatorcontrib>TAKEYAMA, MASAHARU</creatorcontrib><creatorcontrib>KOYAMA, KANAME</creatorcontrib><creatorcontrib>YAJIMA, HARUAKI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KITADA, CHIEKO</au><au>ASHIDA, YASUKO</au><au>MAKI, YOSHITAKA</au><au>FUJINO, MASAHIKO</au><au>HIRAI, YUKO</au><au>YASUHARA, TADASHI</au><au>NAKAJIMA, TERUMI</au><au>TAKEYAMA, MASAHARU</au><au>KOYAMA, KANAME</au><au>YAJIMA, HARUAKI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of Granuliberin-R and Various Fragment Peptides and Their Histamine-Releasing Activities</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1980-01-01</date><risdate>1980</risdate><volume>28</volume><issue>3</issue><spage>887</spage><epage>892</epage><pages>887-892</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>Granuliberin-R and various fragment peptides were synthesized and their histaminereleasing activities were examined. The relative potencies of granuliberin-R, H-Phe-Gly-Phe-Leu-Pro-Ile-Tyr-Arg-Arg-Pro-Ala-Ser-NH2, as liberators of histamine from mast cells are very similar to those of substance P and bradykinin. Studies on the histamine-releasing activity of various fragment peptides of granuliberin-R showed that a 4-amino acid central sequence, -Ile-Tyr-Arg-Arg-, is the minimum requirement for the releasing action of this frog skin peptide.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>6156021</pmid><doi>10.1248/cpb.28.887</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-2363 |
| ispartof | Chemical and Pharmaceutical Bulletin, 1980/03/25, Vol.28(3), pp.887-892 |
| issn | 0009-2363 1347-5223 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75163271 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Free Full-Text Journals in Chemistry |
| subjects | Animals Cytoplasmic Granules - drug effects fragment peptides of granuliberin-R Histamine Release - drug effects In Vitro Techniques Mast Cells - drug effects Oligopeptides - chemical synthesis Oligopeptides - pharmacology Peptide Fragments - chemical synthesis Peptide Fragments - pharmacology Rats |
| title | Synthesis of Granuliberin-R and Various Fragment Peptides and Their Histamine-Releasing Activities |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T20%3A29%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis%20of%20Granuliberin-R%20and%20Various%20Fragment%20Peptides%20and%20Their%20Histamine-Releasing%20Activities&rft.jtitle=Chemical%20&%20pharmaceutical%20bulletin&rft.au=KITADA,%20CHIEKO&rft.date=1980-01-01&rft.volume=28&rft.issue=3&rft.spage=887&rft.epage=892&rft.pages=887-892&rft.issn=0009-2363&rft.eissn=1347-5223&rft_id=info:doi/10.1248/cpb.28.887&rft_dat=%3Cproquest_cross%3E3132030481%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1459896057&rft_id=info:pmid/6156021&rfr_iscdi=true |