Bile layering: a cause for false-positive cholescintiscans
A number of /sup 99m/Tc-labeled pharmaceuticals have been introduced recently for evaluation and diagnosis of hepatobiliary disease. Pyridoxylidene glutamate (PG) and iminodiacetic acid derivatives have evolved as the most useful agents due to excellent biliary excretion with rapid visualization of...
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| Veröffentlicht in: | Am. J. Roentgenol.; (United States) 1980-06, Vol.134 (6), p.1251-1253 |
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| creator | Rao, B K Lieberman, L M |
| description | A number of /sup 99m/Tc-labeled pharmaceuticals have been introduced recently for evaluation and diagnosis of hepatobiliary disease. Pyridoxylidene glutamate (PG) and iminodiacetic acid derivatives have evolved as the most useful agents due to excellent biliary excretion with rapid visualization of the gallbladder and the biliary ducts. These radiopharmaceuticals offer substantial advantages over /sup 131/I-rose bengal. In our experience of over 80 patients evaluated for various hepatobiliary disorders with /sup 99m/Tc PG or paraisopropyl acetanilidoiminodiacetic acid (PIPIDA), two patients had early cholescintigrams suggestive of intraluminal defects. These were not confirmed on delayed imaging. The cholescintigrams in these two patients were similar and suggested bile layering. Although demonstration of this phenomenon by oral cholecystography and intravenous cholangiography has been reported, we found no description of bile layering with radiopharmaceuticals. |
| doi_str_mv | 10.2214/ajr.134.6.1251 |
| format | Article |
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Pyridoxylidene glutamate (PG) and iminodiacetic acid derivatives have evolved as the most useful agents due to excellent biliary excretion with rapid visualization of the gallbladder and the biliary ducts. These radiopharmaceuticals offer substantial advantages over /sup 131/I-rose bengal. In our experience of over 80 patients evaluated for various hepatobiliary disorders with /sup 99m/Tc PG or paraisopropyl acetanilidoiminodiacetic acid (PIPIDA), two patients had early cholescintigrams suggestive of intraluminal defects. These were not confirmed on delayed imaging. The cholescintigrams in these two patients were similar and suggested bile layering. Although demonstration of this phenomenon by oral cholecystography and intravenous cholangiography has been reported, we found no description of bile layering with radiopharmaceuticals.</description><identifier>ISSN: 0361-803X</identifier><identifier>EISSN: 1546-3141</identifier><identifier>DOI: 10.2214/ajr.134.6.1251</identifier><identifier>PMID: 6770639</identifier><language>eng</language><publisher>United States</publisher><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics ; ACETIC ACID ESTERS ; Acute Disease ; AMINO ACIDS ; AZINES ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; BILE ; BILIARY TRACT ; BIOLOGICAL MATERIALS ; BODY ; BODY FLUIDS ; CARBOXYLIC ACID ESTERS ; CARBOXYLIC ACIDS ; Cholecystitis - diagnostic imaging ; Cholecystography ; Cholestasis - diagnostic imaging ; COMPARATIVE EVALUATIONS ; COUNTING TECHNIQUES ; DAYS LIVING RADIOISOTOPES ; DIAGNOSIS ; Diagnosis, Differential ; DIAGNOSTIC TECHNIQUES ; DIGESTIVE SYSTEM ; DIGESTIVE SYSTEM DISEASES ; DISEASES ; DYES ; ERRORS ; ESTERS ; False Positive Reactions ; Female ; Gallbladder - diagnostic imaging ; Gallbladder Diseases - diagnostic imaging ; GLANDS ; Glutamates ; GLUTAMIC ACID ; HETEROCYCLIC COMPOUNDS ; HOURS LIVING RADIOISOTOPES ; Humans ; HYDROXY ACIDS ; Imino Acids ; INDICATORS ; INTERMEDIATE MASS NUCLEI ; IODINE 131 ; IODINE ISOTOPES ; ISOMERIC NUCLEI ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPES ; LIVER ; Male ; MATERIALS ; Middle Aged ; NUCLEI ; ODD-EVEN NUCLEI ; ORGANIC ACIDS ; ORGANIC CHLORINE COMPOUNDS ; ORGANIC COMPOUNDS ; ORGANIC HALOGEN COMPOUNDS ; ORGANIC IODINE COMPOUNDS ; ORGANIC NITROGEN COMPOUNDS ; Organotechnetium Compounds ; ORGANS ; PATIENTS ; Posture ; PYRIDINES ; Pyridoxal - analogs & derivatives ; PYRIDOXYLIDENEGLUTAMATE ; RADIOISOTOPE SCANNING ; RADIOISOTOPES ; RADIOLOGY AND NUCLEAR MEDICINE ; Radionuclide Imaging ; REAGENTS ; ROSE BENGAL ; SCINTISCANNING ; Technetium ; TECHNETIUM 99 ; TECHNETIUM ISOTOPES ; YEARS LIVING RADIOISOTOPES</subject><ispartof>Am. 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J. Roentgenol.; (United States)</title><addtitle>AJR Am J Roentgenol</addtitle><description>A number of /sup 99m/Tc-labeled pharmaceuticals have been introduced recently for evaluation and diagnosis of hepatobiliary disease. Pyridoxylidene glutamate (PG) and iminodiacetic acid derivatives have evolved as the most useful agents due to excellent biliary excretion with rapid visualization of the gallbladder and the biliary ducts. These radiopharmaceuticals offer substantial advantages over /sup 131/I-rose bengal. In our experience of over 80 patients evaluated for various hepatobiliary disorders with /sup 99m/Tc PG or paraisopropyl acetanilidoiminodiacetic acid (PIPIDA), two patients had early cholescintigrams suggestive of intraluminal defects. These were not confirmed on delayed imaging. The cholescintigrams in these two patients were similar and suggested bile layering. Although demonstration of this phenomenon by oral cholecystography and intravenous cholangiography has been reported, we found no description of bile layering with radiopharmaceuticals.</description><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics</subject><subject>ACETIC ACID ESTERS</subject><subject>Acute Disease</subject><subject>AMINO ACIDS</subject><subject>AZINES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>BILE</subject><subject>BILIARY TRACT</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BODY</subject><subject>BODY FLUIDS</subject><subject>CARBOXYLIC ACID ESTERS</subject><subject>CARBOXYLIC ACIDS</subject><subject>Cholecystitis - diagnostic imaging</subject><subject>Cholecystography</subject><subject>Cholestasis - diagnostic imaging</subject><subject>COMPARATIVE EVALUATIONS</subject><subject>COUNTING TECHNIQUES</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DIAGNOSIS</subject><subject>Diagnosis, Differential</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>DIGESTIVE SYSTEM</subject><subject>DIGESTIVE SYSTEM DISEASES</subject><subject>DISEASES</subject><subject>DYES</subject><subject>ERRORS</subject><subject>ESTERS</subject><subject>False Positive Reactions</subject><subject>Female</subject><subject>Gallbladder - diagnostic imaging</subject><subject>Gallbladder Diseases - diagnostic imaging</subject><subject>GLANDS</subject><subject>Glutamates</subject><subject>GLUTAMIC ACID</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HOURS LIVING RADIOISOTOPES</subject><subject>Humans</subject><subject>HYDROXY ACIDS</subject><subject>Imino Acids</subject><subject>INDICATORS</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>IODINE 131</subject><subject>IODINE ISOTOPES</subject><subject>ISOMERIC NUCLEI</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPES</subject><subject>LIVER</subject><subject>Male</subject><subject>MATERIALS</subject><subject>Middle Aged</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC CHLORINE COMPOUNDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC HALOGEN COMPOUNDS</subject><subject>ORGANIC IODINE COMPOUNDS</subject><subject>ORGANIC NITROGEN COMPOUNDS</subject><subject>Organotechnetium Compounds</subject><subject>ORGANS</subject><subject>PATIENTS</subject><subject>Posture</subject><subject>PYRIDINES</subject><subject>Pyridoxal - analogs & derivatives</subject><subject>PYRIDOXYLIDENEGLUTAMATE</subject><subject>RADIOISOTOPE SCANNING</subject><subject>RADIOISOTOPES</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radionuclide Imaging</subject><subject>REAGENTS</subject><subject>ROSE BENGAL</subject><subject>SCINTISCANNING</subject><subject>Technetium</subject><subject>TECHNETIUM 99</subject><subject>TECHNETIUM ISOTOPES</subject><subject>YEARS LIVING RADIOISOTOPES</subject><issn>0361-803X</issn><issn>1546-3141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM9LwzAUx4Moc06v3oTiwVtrXpM0iTcd_oKBFwVvIUvfXEbXzKQV9t_bueHpXT7vw5cPIZdAi7IEfmtXsQDGi6qAUsARGYPgVc6AwzEZU1ZBrij7PCVnKa0opVJpOSKjSkpaMT0mdw--wayxW4y-_brLbOZsnzBbhJgtbJMw34TkO_-DmVuGBpPzbeeTs206Jyd_xMXhTsjH0-P79CWfvT2_Tu9nuWNCdjlHJpgqFapSlJY7AUxDidbVVHEpUc-Fc6JW81pTV1lYSMuo5lppBxyRswm53ntD6rwZBnToli60LbrOCEZBMRigmz20ieG7x9SZ9bASm8a2GPpkpAAuBdvZij3oYkgp4sJsol_buDVAza6oGYqaoaipzK7o8HB1MPfzNdb_-CEh-wXfQnBG</recordid><startdate>198006</startdate><enddate>198006</enddate><creator>Rao, B K</creator><creator>Lieberman, L M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198006</creationdate><title>Bile layering: a cause for false-positive cholescintiscans</title><author>Rao, B K ; Lieberman, L M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-4e353828e8252a4c513912eacd08477e9b5cc5d8bd90c6a1f7a3094989c14ee43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>550601 - Medicine- Unsealed Radionuclides in Diagnostics</topic><topic>ACETIC ACID ESTERS</topic><topic>Acute Disease</topic><topic>AMINO ACIDS</topic><topic>AZINES</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>BILE</topic><topic>BILIARY TRACT</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BODY</topic><topic>BODY FLUIDS</topic><topic>CARBOXYLIC ACID ESTERS</topic><topic>CARBOXYLIC ACIDS</topic><topic>Cholecystitis - diagnostic imaging</topic><topic>Cholecystography</topic><topic>Cholestasis - diagnostic imaging</topic><topic>COMPARATIVE EVALUATIONS</topic><topic>COUNTING TECHNIQUES</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DIAGNOSIS</topic><topic>Diagnosis, Differential</topic><topic>DIAGNOSTIC TECHNIQUES</topic><topic>DIGESTIVE SYSTEM</topic><topic>DIGESTIVE SYSTEM DISEASES</topic><topic>DISEASES</topic><topic>DYES</topic><topic>ERRORS</topic><topic>ESTERS</topic><topic>False Positive Reactions</topic><topic>Female</topic><topic>Gallbladder - diagnostic imaging</topic><topic>Gallbladder Diseases - diagnostic imaging</topic><topic>GLANDS</topic><topic>Glutamates</topic><topic>GLUTAMIC ACID</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HOURS LIVING RADIOISOTOPES</topic><topic>Humans</topic><topic>HYDROXY ACIDS</topic><topic>Imino Acids</topic><topic>INDICATORS</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>IODINE 131</topic><topic>IODINE ISOTOPES</topic><topic>ISOMERIC NUCLEI</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPES</topic><topic>LIVER</topic><topic>Male</topic><topic>MATERIALS</topic><topic>Middle Aged</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC CHLORINE COMPOUNDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC HALOGEN COMPOUNDS</topic><topic>ORGANIC IODINE COMPOUNDS</topic><topic>ORGANIC NITROGEN COMPOUNDS</topic><topic>Organotechnetium Compounds</topic><topic>ORGANS</topic><topic>PATIENTS</topic><topic>Posture</topic><topic>PYRIDINES</topic><topic>Pyridoxal - analogs & derivatives</topic><topic>PYRIDOXYLIDENEGLUTAMATE</topic><topic>RADIOISOTOPE SCANNING</topic><topic>RADIOISOTOPES</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radionuclide Imaging</topic><topic>REAGENTS</topic><topic>ROSE BENGAL</topic><topic>SCINTISCANNING</topic><topic>Technetium</topic><topic>TECHNETIUM 99</topic><topic>TECHNETIUM ISOTOPES</topic><topic>YEARS LIVING RADIOISOTOPES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rao, B K</creatorcontrib><creatorcontrib>Lieberman, L M</creatorcontrib><creatorcontrib>Univ. of Wisconsin Hospital and Clinics, Madison</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Am. J. Roentgenol.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rao, B K</au><au>Lieberman, L M</au><aucorp>Univ. of Wisconsin Hospital and Clinics, Madison</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bile layering: a cause for false-positive cholescintiscans</atitle><jtitle>Am. J. Roentgenol.; (United States)</jtitle><addtitle>AJR Am J Roentgenol</addtitle><date>1980-06</date><risdate>1980</risdate><volume>134</volume><issue>6</issue><spage>1251</spage><epage>1253</epage><pages>1251-1253</pages><issn>0361-803X</issn><eissn>1546-3141</eissn><abstract>A number of /sup 99m/Tc-labeled pharmaceuticals have been introduced recently for evaluation and diagnosis of hepatobiliary disease. Pyridoxylidene glutamate (PG) and iminodiacetic acid derivatives have evolved as the most useful agents due to excellent biliary excretion with rapid visualization of the gallbladder and the biliary ducts. These radiopharmaceuticals offer substantial advantages over /sup 131/I-rose bengal. In our experience of over 80 patients evaluated for various hepatobiliary disorders with /sup 99m/Tc PG or paraisopropyl acetanilidoiminodiacetic acid (PIPIDA), two patients had early cholescintigrams suggestive of intraluminal defects. These were not confirmed on delayed imaging. The cholescintigrams in these two patients were similar and suggested bile layering. Although demonstration of this phenomenon by oral cholecystography and intravenous cholangiography has been reported, we found no description of bile layering with radiopharmaceuticals.</abstract><cop>United States</cop><pmid>6770639</pmid><doi>10.2214/ajr.134.6.1251</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0361-803X |
| ispartof | Am. J. Roentgenol.; (United States), 1980-06, Vol.134 (6), p.1251-1253 |
| issn | 0361-803X 1546-3141 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75147534 |
| source | American Roentgen Ray Society; MEDLINE; Alma/SFX Local Collection |
| subjects | 550601 - Medicine- Unsealed Radionuclides in Diagnostics ACETIC ACID ESTERS Acute Disease AMINO ACIDS AZINES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BILE BILIARY TRACT BIOLOGICAL MATERIALS BODY BODY FLUIDS CARBOXYLIC ACID ESTERS CARBOXYLIC ACIDS Cholecystitis - diagnostic imaging Cholecystography Cholestasis - diagnostic imaging COMPARATIVE EVALUATIONS COUNTING TECHNIQUES DAYS LIVING RADIOISOTOPES DIAGNOSIS Diagnosis, Differential DIAGNOSTIC TECHNIQUES DIGESTIVE SYSTEM DIGESTIVE SYSTEM DISEASES DISEASES DYES ERRORS ESTERS False Positive Reactions Female Gallbladder - diagnostic imaging Gallbladder Diseases - diagnostic imaging GLANDS Glutamates GLUTAMIC ACID HETEROCYCLIC COMPOUNDS HOURS LIVING RADIOISOTOPES Humans HYDROXY ACIDS Imino Acids INDICATORS INTERMEDIATE MASS NUCLEI IODINE 131 IODINE ISOTOPES ISOMERIC NUCLEI ISOMERIC TRANSITION ISOTOPES ISOTOPES LIVER Male MATERIALS Middle Aged NUCLEI ODD-EVEN NUCLEI ORGANIC ACIDS ORGANIC CHLORINE COMPOUNDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS ORGANIC IODINE COMPOUNDS ORGANIC NITROGEN COMPOUNDS Organotechnetium Compounds ORGANS PATIENTS Posture PYRIDINES Pyridoxal - analogs & derivatives PYRIDOXYLIDENEGLUTAMATE RADIOISOTOPE SCANNING RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE Radionuclide Imaging REAGENTS ROSE BENGAL SCINTISCANNING Technetium TECHNETIUM 99 TECHNETIUM ISOTOPES YEARS LIVING RADIOISOTOPES |
| title | Bile layering: a cause for false-positive cholescintiscans |
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