Potassium uptake by platelets from Down's syndrome and normal subjects
Potassium uptake was studied in Down's syndrome (D.S.) platelets to determine if the Na +/K + ATPase mediated movement of this ion was decreased compared to normal platelets. Total uptake of 42K was 1.58±0.16 μmoles/hr/10 9 normal platelets but was decreased to 1.06±0.06 μmoles/hr/10 9 D.S. pla...
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| Veröffentlicht in: | Life sciences (1973) 1980-02, Vol.26 (8), p.603-606 |
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| container_title | Life sciences (1973) |
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| creator | McCoy, Ernest E. Enns, Louise |
| description | Potassium uptake was studied in Down's syndrome (D.S.) platelets to determine if the Na
+/K
+ ATPase mediated movement of this ion was decreased compared to normal platelets. Total uptake of
42K was 1.58±0.16 μmoles/hr/10
9 normal platelets but was decreased to 1.06±0.06 μmoles/hr/10
9 D.S. platelets (p |
| doi_str_mv | 10.1016/0024-3205(80)90235-0 |
| format | Article |
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+/K
+ ATPase mediated movement of this ion was decreased compared to normal platelets. Total uptake of
42K was 1.58±0.16 μmoles/hr/10
9 normal platelets but was decreased to 1.06±0.06 μmoles/hr/10
9 D.S. platelets (p<.001). Na
+/K
+ ATPase mediated (ouabain sensitive) K
+ uptake was 0.87±0.05 μmoles/hr/10
9 normal platelets but only 0.54±0.04 μmoles/hr/10
9 in D.S. platelets (p<.001). As the Na
+/K
+ ATPase mediated outward movement of Na
+ is decreased in D.S. platelets, the present work demonstrates that bidirectional functional imparrment of the Na
+/K
+ ATPase pump is present in D.S. platelets.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(80)90235-0</identifier><identifier>PMID: 6446013</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Blood Platelets - drug effects ; Blood Platelets - metabolism ; Down Syndrome - blood ; Humans ; Kinetics ; Ouabain - pharmacology ; Potassium - blood ; Potassium Radioisotopes</subject><ispartof>Life sciences (1973), 1980-02, Vol.26 (8), p.603-606</ispartof><rights>1980</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-f21d748e280f3d5bd958463ba7d206b9c861f423a4a71aeea5a1674d1bf38c13</citedby><cites>FETCH-LOGICAL-c357t-f21d748e280f3d5bd958463ba7d206b9c861f423a4a71aeea5a1674d1bf38c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0024-3205(80)90235-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6446013$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McCoy, Ernest E.</creatorcontrib><creatorcontrib>Enns, Louise</creatorcontrib><title>Potassium uptake by platelets from Down's syndrome and normal subjects</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Potassium uptake was studied in Down's syndrome (D.S.) platelets to determine if the Na
+/K
+ ATPase mediated movement of this ion was decreased compared to normal platelets. Total uptake of
42K was 1.58±0.16 μmoles/hr/10
9 normal platelets but was decreased to 1.06±0.06 μmoles/hr/10
9 D.S. platelets (p<.001). Na
+/K
+ ATPase mediated (ouabain sensitive) K
+ uptake was 0.87±0.05 μmoles/hr/10
9 normal platelets but only 0.54±0.04 μmoles/hr/10
9 in D.S. platelets (p<.001). As the Na
+/K
+ ATPase mediated outward movement of Na
+ is decreased in D.S. platelets, the present work demonstrates that bidirectional functional imparrment of the Na
+/K
+ ATPase pump is present in D.S. platelets.</description><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - metabolism</subject><subject>Down Syndrome - blood</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Ouabain - pharmacology</subject><subject>Potassium - blood</subject><subject>Potassium Radioisotopes</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLw0AQxxdRaq1-A4U9-ThEZ7OPbC6C1CcU9ND7sslOIDUvdxOl397Ulh49DcP_McyPkHMGtwyYugOIRcRjkNcablKIuYzggEyZTtIIFGeHZLq3HJOTEFYAIGXCJ2SihFDA-JQ8f7S9DaEcajp0vf1Emq1pV9keK-wDLXxb08f2p7kKNKwbN65IbeNo0_raVjQM2QrzPpySo8JWAc92c0aWz0_L-Wu0eH95mz8sopzLpI-KmLlEaIw1FNzJzKVSC8Uzm7gYVJbmWrFCxNwKmzCLaKVlKhGOZQXXOeMzcrmt7Xz7NWDoTV2GHKvKNtgOwSSScZ3GcjSKrTH3bQgeC9P5srZ-bRiYDT2zQWM2aIwG80fPwBi72PUPWY1uH9rhGvX7rY7jj98lehPyEpscXelHDMa15f8HfgHNcn4N</recordid><startdate>19800225</startdate><enddate>19800225</enddate><creator>McCoy, Ernest E.</creator><creator>Enns, Louise</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19800225</creationdate><title>Potassium uptake by platelets from Down's syndrome and normal subjects</title><author>McCoy, Ernest E. ; Enns, Louise</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-f21d748e280f3d5bd958463ba7d206b9c861f423a4a71aeea5a1674d1bf38c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - metabolism</topic><topic>Down Syndrome - blood</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Ouabain - pharmacology</topic><topic>Potassium - blood</topic><topic>Potassium Radioisotopes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McCoy, Ernest E.</creatorcontrib><creatorcontrib>Enns, Louise</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McCoy, Ernest E.</au><au>Enns, Louise</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potassium uptake by platelets from Down's syndrome and normal subjects</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1980-02-25</date><risdate>1980</risdate><volume>26</volume><issue>8</issue><spage>603</spage><epage>606</epage><pages>603-606</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Potassium uptake was studied in Down's syndrome (D.S.) platelets to determine if the Na
+/K
+ ATPase mediated movement of this ion was decreased compared to normal platelets. Total uptake of
42K was 1.58±0.16 μmoles/hr/10
9 normal platelets but was decreased to 1.06±0.06 μmoles/hr/10
9 D.S. platelets (p<.001). Na
+/K
+ ATPase mediated (ouabain sensitive) K
+ uptake was 0.87±0.05 μmoles/hr/10
9 normal platelets but only 0.54±0.04 μmoles/hr/10
9 in D.S. platelets (p<.001). As the Na
+/K
+ ATPase mediated outward movement of Na
+ is decreased in D.S. platelets, the present work demonstrates that bidirectional functional imparrment of the Na
+/K
+ ATPase pump is present in D.S. platelets.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>6446013</pmid><doi>10.1016/0024-3205(80)90235-0</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 1980-02, Vol.26 (8), p.603-606 |
| issn | 0024-3205 1879-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75138925 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Blood Platelets - drug effects Blood Platelets - metabolism Down Syndrome - blood Humans Kinetics Ouabain - pharmacology Potassium - blood Potassium Radioisotopes |
| title | Potassium uptake by platelets from Down's syndrome and normal subjects |
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