In vitro Adsorption Studies of Cimetidine
The adsorption of cimetidine on selected pharmaceuticals including kaolin, activated charcoal, talc, and nonsystemic antacids was determined at pH 5.0 and 25°. The Langmuir and Freundlich adsorption isotherms showed that cimetidine adsorption was significant with activated charcoal, kaolin, talc, an...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1980-03, Vol.69 (3), p.352-353 |
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| container_end_page | 353 |
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| container_issue | 3 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 69 |
| creator | Ganjian, F. Cutie, A.J. Jochsberger, T. |
| description | The adsorption of cimetidine on selected pharmaceuticals including kaolin, activated charcoal, talc, and nonsystemic antacids was determined at pH 5.0 and 25°. The Langmuir and Freundlich adsorption isotherms showed that cimetidine adsorption was significant with activated charcoal, kaolin, talc, and magnesium trisilicate and was virtually nonexistent with magnesium hydroxide and aluminum hydroxide. Equations expressing the Freundlich and Langmuir adsorption isotherms were evaluated for each adsorbent. The approximate amounts of cimetidine adsorbed per gram of adsorbent were 25.6, 0.402, 0.291, and 0.343mg for charcoal, kaolin, talc, and magnesium trisilicate, respectively. These in vitro studies indicate that some cimetidine may be lost when it is administered concomitantly with pharmaceutical adsorbents. |
| doi_str_mv | 10.1002/jps.2600690329 |
| format | Article |
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The Langmuir and Freundlich adsorption isotherms showed that cimetidine adsorption was significant with activated charcoal, kaolin, talc, and magnesium trisilicate and was virtually nonexistent with magnesium hydroxide and aluminum hydroxide. Equations expressing the Freundlich and Langmuir adsorption isotherms were evaluated for each adsorbent. The approximate amounts of cimetidine adsorbed per gram of adsorbent were 25.6, 0.402, 0.291, and 0.343mg for charcoal, kaolin, talc, and magnesium trisilicate, respectively. These in vitro studies indicate that some cimetidine may be lost when it is administered concomitantly with pharmaceutical adsorbents.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600690329</identifier><identifier>PMID: 7381720</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Adsorption ; Adsorption-cimetidine ; Adsorption—cimetidine, various pharmaceutical adsorbents, in vitro ; Charcoal ; Cimetidine ; Cimetidine-adsorption onto various pharmaceutical adsorbents ; Cimetidine—adsorption onto various pharmaceutical adsorbents, in vitro ; Guanidines ; in vitro ; Interactions-adsorption of cimetidine onto various pharmaceutical adsorbents ; Kinetics ; Thermodynamics ; various pharmaceutical adsorbents</subject><ispartof>Journal of pharmaceutical sciences, 1980-03, Vol.69 (3), p.352-353</ispartof><rights>1980 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1980 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3429-139257b67acf14eb68f27c0888cbaec8c661632ba07278e2763b0db42563e8373</citedby><cites>FETCH-LOGICAL-c3429-139257b67acf14eb68f27c0888cbaec8c661632ba07278e2763b0db42563e8373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600690329$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600690329$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7381720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ganjian, F.</creatorcontrib><creatorcontrib>Cutie, A.J.</creatorcontrib><creatorcontrib>Jochsberger, T.</creatorcontrib><title>In vitro Adsorption Studies of Cimetidine</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>The adsorption of cimetidine on selected pharmaceuticals including kaolin, activated charcoal, talc, and nonsystemic antacids was determined at pH 5.0 and 25°. The Langmuir and Freundlich adsorption isotherms showed that cimetidine adsorption was significant with activated charcoal, kaolin, talc, and magnesium trisilicate and was virtually nonexistent with magnesium hydroxide and aluminum hydroxide. Equations expressing the Freundlich and Langmuir adsorption isotherms were evaluated for each adsorbent. The approximate amounts of cimetidine adsorbed per gram of adsorbent were 25.6, 0.402, 0.291, and 0.343mg for charcoal, kaolin, talc, and magnesium trisilicate, respectively. These in vitro studies indicate that some cimetidine may be lost when it is administered concomitantly with pharmaceutical adsorbents.</description><subject>Adsorption</subject><subject>Adsorption-cimetidine</subject><subject>Adsorption—cimetidine, various pharmaceutical adsorbents, in vitro</subject><subject>Charcoal</subject><subject>Cimetidine</subject><subject>Cimetidine-adsorption onto various pharmaceutical adsorbents</subject><subject>Cimetidine—adsorption onto various pharmaceutical adsorbents, in vitro</subject><subject>Guanidines</subject><subject>in vitro</subject><subject>Interactions-adsorption of cimetidine onto various pharmaceutical adsorbents</subject><subject>Kinetics</subject><subject>Thermodynamics</subject><subject>various pharmaceutical adsorbents</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLw0AUhQdRaq1u3QlZCS5S55HMTJa1aFspPmjF5ZBMbmBqHnUmqfbfG0mpuBBXd3G-c-B-CJ0TPCQY0-vV2g0px5hHmNHoAPVJSLHPMRGHqN8C1GdhEB2jE-dWuMVwGPZQTzBJBMV9dDUrvY2pbeWNUlfZdW2q0lvUTWrAeVXmjU0BtUlNCafoKItzB2e7O0Avd7fL8dSfP05m49Hc1yygkU9YREORcBHrjASQcJlRobGUUicxaKk5J5zRJMaCCglUcJbgNAloyBlIJtgAXXa7a1u9N-BqVRinIc_jEqrGKRESFvC2NkDDDtS2cs5CptbWFLHdKoLVtxvVulE_btrCxW65SQpI9_hORptHXf5hctj-s6bunxa_tv2ua1wNn_tubN8UF0yE6vVhop7x9GEe3BC1bHnZ8dCq3BiwymkDpYbUWNC1Sivz1xtfPyyPsA</recordid><startdate>198003</startdate><enddate>198003</enddate><creator>Ganjian, F.</creator><creator>Cutie, A.J.</creator><creator>Jochsberger, T.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198003</creationdate><title>In vitro Adsorption Studies of Cimetidine</title><author>Ganjian, F. ; Cutie, A.J. ; Jochsberger, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3429-139257b67acf14eb68f27c0888cbaec8c661632ba07278e2763b0db42563e8373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Adsorption</topic><topic>Adsorption-cimetidine</topic><topic>Adsorption—cimetidine, various pharmaceutical adsorbents, in vitro</topic><topic>Charcoal</topic><topic>Cimetidine</topic><topic>Cimetidine-adsorption onto various pharmaceutical adsorbents</topic><topic>Cimetidine—adsorption onto various pharmaceutical adsorbents, in vitro</topic><topic>Guanidines</topic><topic>in vitro</topic><topic>Interactions-adsorption of cimetidine onto various pharmaceutical adsorbents</topic><topic>Kinetics</topic><topic>Thermodynamics</topic><topic>various pharmaceutical adsorbents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ganjian, F.</creatorcontrib><creatorcontrib>Cutie, A.J.</creatorcontrib><creatorcontrib>Jochsberger, T.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ganjian, F.</au><au>Cutie, A.J.</au><au>Jochsberger, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro Adsorption Studies of Cimetidine</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1980-03</date><risdate>1980</risdate><volume>69</volume><issue>3</issue><spage>352</spage><epage>353</epage><pages>352-353</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>The adsorption of cimetidine on selected pharmaceuticals including kaolin, activated charcoal, talc, and nonsystemic antacids was determined at pH 5.0 and 25°. The Langmuir and Freundlich adsorption isotherms showed that cimetidine adsorption was significant with activated charcoal, kaolin, talc, and magnesium trisilicate and was virtually nonexistent with magnesium hydroxide and aluminum hydroxide. Equations expressing the Freundlich and Langmuir adsorption isotherms were evaluated for each adsorbent. The approximate amounts of cimetidine adsorbed per gram of adsorbent were 25.6, 0.402, 0.291, and 0.343mg for charcoal, kaolin, talc, and magnesium trisilicate, respectively. These in vitro studies indicate that some cimetidine may be lost when it is administered concomitantly with pharmaceutical adsorbents.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>7381720</pmid><doi>10.1002/jps.2600690329</doi><tpages>2</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1980-03, Vol.69 (3), p.352-353 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | Adsorption Adsorption-cimetidine Adsorption—cimetidine, various pharmaceutical adsorbents, in vitro Charcoal Cimetidine Cimetidine-adsorption onto various pharmaceutical adsorbents Cimetidine—adsorption onto various pharmaceutical adsorbents, in vitro Guanidines in vitro Interactions-adsorption of cimetidine onto various pharmaceutical adsorbents Kinetics Thermodynamics various pharmaceutical adsorbents |
| title | In vitro Adsorption Studies of Cimetidine |
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