Immunofluorescence microscopy of a myopathy: α-Actinin is a major constituent of nemaline rods

A biopsy of skeletal muscle taken from a child with the clinical symptoms of congenital nemaline myopathy was studied. Light and electron microscopy revealed rod-like structures within the muscle fibres, and thus confirmed the clinical diagnosis. Indirect immunofluorescence, using specific antibodie...

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Veröffentlicht in:	Experimental cell research 1980-01, Vol.127 (2), p.409-420
Hauptverfasser:	Jockusch, Brigitte M., Veldman, Henk, Griffiths, Gareth W., Van Oost, Bernard A., Jennekens, Frans G.I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinin - analysis Actins - analysis Child, Preschool Desmin Fluorescent Antibody Technique Humans Male Muscle Proteins - analysis Muscles - analysis Muscles - pathology Muscular Diseases - congenital Muscular Diseases - metabolism Muscular Diseases - pathology Myofibrils - ultrastructure Tropomyosin - analysis
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