Properties of antithrombin III depleted plasma I. Effect of heparin

Antithrombin III depleted plasma was prepared by immunosorption. The plasma was shown to retain all factors necessary for normal coagulation and the level of the protease inhibitors α 1-antitrypsin and α 2-macroglobulin was not affected. The addition of heparin to this plasma had no effect on the in...

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Veröffentlicht in:	Thrombosis research 1980, Vol.17 (1), p.113-124
Hauptverfasser:	Holmer, E., Söderström, G., Andersson, L.-O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antithrombin III Binding Sites Factor X - antagonists & inhibitors Fibrinogen - metabolism Heparin - pharmacology Humans Immunosorbent Techniques Partial Thromboplastin Time Swine Thrombin - antagonists & inhibitors Thrombosis - blood
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container_title	Thrombosis research
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creator	Holmer, E. Söderström, G. Andersson, L.-O.
description	Antithrombin III depleted plasma was prepared by immunosorption. The plasma was shown to retain all factors necessary for normal coagulation and the level of the protease inhibitors α 1-antitrypsin and α 2-macroglobulin was not affected. The addition of heparin to this plasma had no effect on the inhibition of thrombin and factor X a and only slightly prolonged the coagulation time as measured by the APTT test. When purified antithrombin III was added to the depleted plasma the effect of heparin on the inhibition of thrombin and factor X a and on the over-all clotting time was restored. The formation of antithrombin III-heparin complex in heparinized plasma was shown using an immunosorption technique.
doi_str_mv	10.1016/0049-3848(80)90299-6
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The formation of antithrombin III-heparin complex in heparinized plasma was shown using an immunosorption technique.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/0049-3848(80)90299-6</identifier><identifier>PMID: 6990545</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Animals ; Antithrombin III ; Binding Sites ; Factor X - antagonists & inhibitors ; Fibrinogen - metabolism ; Heparin - pharmacology ; Humans ; Immunosorbent Techniques ; Partial Thromboplastin Time ; Swine ; Thrombin - antagonists & inhibitors ; Thrombosis - blood</subject><ispartof>Thrombosis research, 1980, Vol.17 (1), p.113-124</ispartof><rights>1980</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-32fc7b66096272d15f7571a00cfd9e6dc71fb9dacd71fe8bc488c5ee6d37e0593</citedby><cites>FETCH-LOGICAL-c272t-32fc7b66096272d15f7571a00cfd9e6dc71fb9dacd71fe8bc488c5ee6d37e0593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0049384880902996$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6990545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holmer, E.</creatorcontrib><creatorcontrib>Söderström, G.</creatorcontrib><creatorcontrib>Andersson, L.-O.</creatorcontrib><title>Properties of antithrombin III depleted plasma I. 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The formation of antithrombin III-heparin complex in heparinized plasma was shown using an immunosorption technique.</description><subject>Animals</subject><subject>Antithrombin III</subject><subject>Binding Sites</subject><subject>Factor X - antagonists & inhibitors</subject><subject>Fibrinogen - metabolism</subject><subject>Heparin - pharmacology</subject><subject>Humans</subject><subject>Immunosorbent Techniques</subject><subject>Partial Thromboplastin Time</subject><subject>Swine</subject><subject>Thrombin - antagonists & inhibitors</subject><subject>Thrombosis - blood</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo6_rxDxR6Ej10TdqmSS6CLKsWFvSg55AmEzbSL5Ou4L83dZc9epoZ3vedYR6ErgheEEzKe4wLkea84Lcc3wmcCZGWR2hOOBNpVrDsGM0PllN0FsInxoQRQWdoVgqBaUHnaPnm-wH86CAkvU1UN7px4_u2dl1SVVViYGhgBJMMjQqtSqpFsrIW9Di5NzAo77oLdGJVE-ByX8_Rx9PqffmSrl-fq-XjOtUZy8Y0z6xmdVliUcbZEGoZZURhrK0RUBrNiK2FUdrEBnitC841hajkDDAV-Tm62e0dfP-1hTDK1gUNTaM66LdBMkoIyYs8GoudUfs-BA9WDt61yv9IguXETk5g5ARGciz_2Mkyxq73-7d1C-YQ2sOK-sNOh_jktwMvg3bQaTDORyLS9O7_A78gI31B</recordid><startdate>1980</startdate><enddate>1980</enddate><creator>Holmer, E.</creator><creator>Söderström, G.</creator><creator>Andersson, L.-O.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1980</creationdate><title>Properties of antithrombin III depleted plasma I. Effect of heparin</title><author>Holmer, E. ; Söderström, G. ; Andersson, L.-O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-32fc7b66096272d15f7571a00cfd9e6dc71fb9dacd71fe8bc488c5ee6d37e0593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Antithrombin III</topic><topic>Binding Sites</topic><topic>Factor X - antagonists & inhibitors</topic><topic>Fibrinogen - metabolism</topic><topic>Heparin - pharmacology</topic><topic>Humans</topic><topic>Immunosorbent Techniques</topic><topic>Partial Thromboplastin Time</topic><topic>Swine</topic><topic>Thrombin - antagonists & inhibitors</topic><topic>Thrombosis - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holmer, E.</creatorcontrib><creatorcontrib>Söderström, G.</creatorcontrib><creatorcontrib>Andersson, L.-O.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holmer, E.</au><au>Söderström, G.</au><au>Andersson, L.-O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Properties of antithrombin III depleted plasma I. 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subjects	Animals Antithrombin III Binding Sites Factor X - antagonists & inhibitors Fibrinogen - metabolism Heparin - pharmacology Humans Immunosorbent Techniques Partial Thromboplastin Time Swine Thrombin - antagonists & inhibitors Thrombosis - blood
title	Properties of antithrombin III depleted plasma I. Effect of heparin
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