Platelet monoamine oxidase and plasma amine oxidase in psychiatric patients
Platelet monoamine oxidase (MAO) and plasma amine oxidase (PAO) activities were determined in 70 normal controls and 76 psychiatric patients. Platelet MAO activity did not differ between the normal controls and patients diagnosed as schizophrenic or primary affective illness, although there was a st...
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| Veröffentlicht in: | Schizophrenia bulletin 1980, Vol.6 (2), p.213-219 |
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| container_title | Schizophrenia bulletin |
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| creator | Meltzer, H Y Arora, R C Jackman, H Pscheidt, G Smith, M D |
| description | Platelet monoamine oxidase (MAO) and plasma amine oxidase (PAO) activities were determined in 70 normal controls and 76 psychiatric patients. Platelet MAO activity did not differ between the normal controls and patients diagnosed as schizophrenic or primary affective illness, although there was a strong trend for chronic schizophrenics to have lower MAO activity. Schizophrenic patients with Schneiderian-type hallucinatiions had significantly lower MAO activity than normal controls or schizophrenic patients who did not hallucinate. There was no relationship between hallucinations and platelet MAO activity in patients with affective psychoses. Paranoid schizophrenics did not have significantly different MAO activity from nonparanoid schizophrenics. PAO activity was generally lower in all diagnostic groups than in normal controls, but the results were statistically significant only for acute schizophrenics. |
| doi_str_mv | 10.1093/schbul/6.2.213 |
| format | Article |
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Platelet MAO activity did not differ between the normal controls and patients diagnosed as schizophrenic or primary affective illness, although there was a strong trend for chronic schizophrenics to have lower MAO activity. Schizophrenic patients with Schneiderian-type hallucinatiions had significantly lower MAO activity than normal controls or schizophrenic patients who did not hallucinate. There was no relationship between hallucinations and platelet MAO activity in patients with affective psychoses. Paranoid schizophrenics did not have significantly different MAO activity from nonparanoid schizophrenics. PAO activity was generally lower in all diagnostic groups than in normal controls, but the results were statistically significant only for acute schizophrenics.</description><identifier>ISSN: 0586-7614</identifier><identifier>EISSN: 1745-1701</identifier><identifier>DOI: 10.1093/schbul/6.2.213</identifier><identifier>PMID: 7375852</identifier><language>eng</language><publisher>United States: National Institute of Mental Health</publisher><subject>Acute Schizophrenia ; Affective Disorders, Psychotic - enzymology ; Bipolar Disorder - enzymology ; Blood Plasma ; Blood Platelets ; Blood Platelets - enzymology ; Etiology ; Female ; Hallucinations - enzymology ; Human ; Humans ; Male ; Monoamine Oxidase - blood ; Monoamine Oxidases ; Oxidases ; Oxidoreductases Acting on CH-NH Group Donors - blood ; Paranoid Schizophrenia ; Schizophrenia ; Schizophrenia - enzymology ; Schizophrenia, Paranoid - enzymology</subject><ispartof>Schizophrenia bulletin, 1980, Vol.6 (2), p.213-219</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-d3d774955f2c42f27d7c9276485a3c92bf5ff034f8de5f518ad1a88f603422733</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7375852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meltzer, H Y</creatorcontrib><creatorcontrib>Arora, R C</creatorcontrib><creatorcontrib>Jackman, H</creatorcontrib><creatorcontrib>Pscheidt, G</creatorcontrib><creatorcontrib>Smith, M D</creatorcontrib><title>Platelet monoamine oxidase and plasma amine oxidase in psychiatric patients</title><title>Schizophrenia bulletin</title><addtitle>Schizophr Bull</addtitle><description>Platelet monoamine oxidase (MAO) and plasma amine oxidase (PAO) activities were determined in 70 normal controls and 76 psychiatric patients. Platelet MAO activity did not differ between the normal controls and patients diagnosed as schizophrenic or primary affective illness, although there was a strong trend for chronic schizophrenics to have lower MAO activity. Schizophrenic patients with Schneiderian-type hallucinatiions had significantly lower MAO activity than normal controls or schizophrenic patients who did not hallucinate. There was no relationship between hallucinations and platelet MAO activity in patients with affective psychoses. Paranoid schizophrenics did not have significantly different MAO activity from nonparanoid schizophrenics. PAO activity was generally lower in all diagnostic groups than in normal controls, but the results were statistically significant only for acute schizophrenics.</description><subject>Acute Schizophrenia</subject><subject>Affective Disorders, Psychotic - enzymology</subject><subject>Bipolar Disorder - enzymology</subject><subject>Blood Plasma</subject><subject>Blood Platelets</subject><subject>Blood Platelets - enzymology</subject><subject>Etiology</subject><subject>Female</subject><subject>Hallucinations - enzymology</subject><subject>Human</subject><subject>Humans</subject><subject>Male</subject><subject>Monoamine Oxidase - blood</subject><subject>Monoamine Oxidases</subject><subject>Oxidases</subject><subject>Oxidoreductases Acting on CH-NH Group Donors - blood</subject><subject>Paranoid Schizophrenia</subject><subject>Schizophrenia</subject><subject>Schizophrenia - enzymology</subject><subject>Schizophrenia, Paranoid - enzymology</subject><issn>0586-7614</issn><issn>1745-1701</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMtLxDAQh4Mo67p69SYUD97azTvpUcQXLuhBzyGbB5ulTWvTgvvfG9lF0NMMM9_8GD4ALhGsEKzJMpnNemqWvMIVRuQIzJGgrEQComMwh0zyUnBET8FZSlsIEa05noGZIIJJhufg5a3Ro2vcWLRd7HQboiu6r2B1coWOtugbnVpd_F2EWPRpZzZBj0MwRa_H4OKYzsGJ101yF4e6AB8P9-93T-Xq9fH57nZVGsLEWFpihaA1Yx4bij0WVpgaC04l0yR3a8-8h4R6aR3zDEltkZbS8zzDWBCyADf73H7oPieXRtWGZFzT6Oi6KSnBEIKS8wxe_wO33TTE_JvKTrBEXMgMVXvIDF1Kg_OqH0Krh51CUP0oVnvFiiussuJ8cHVIndats7_4wSn5Bn88d_0</recordid><startdate>1980</startdate><enddate>1980</enddate><creator>Meltzer, H Y</creator><creator>Arora, R C</creator><creator>Jackman, H</creator><creator>Pscheidt, G</creator><creator>Smith, M D</creator><general>National Institute of Mental Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>1980</creationdate><title>Platelet monoamine oxidase and plasma amine oxidase in psychiatric patients</title><author>Meltzer, H Y ; Arora, R C ; Jackman, H ; Pscheidt, G ; Smith, M D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-d3d774955f2c42f27d7c9276485a3c92bf5ff034f8de5f518ad1a88f603422733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Acute Schizophrenia</topic><topic>Affective Disorders, Psychotic - enzymology</topic><topic>Bipolar Disorder - enzymology</topic><topic>Blood Plasma</topic><topic>Blood Platelets</topic><topic>Blood Platelets - enzymology</topic><topic>Etiology</topic><topic>Female</topic><topic>Hallucinations - enzymology</topic><topic>Human</topic><topic>Humans</topic><topic>Male</topic><topic>Monoamine Oxidase - blood</topic><topic>Monoamine Oxidases</topic><topic>Oxidases</topic><topic>Oxidoreductases Acting on CH-NH Group Donors - blood</topic><topic>Paranoid Schizophrenia</topic><topic>Schizophrenia</topic><topic>Schizophrenia - enzymology</topic><topic>Schizophrenia, Paranoid - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meltzer, H Y</creatorcontrib><creatorcontrib>Arora, R C</creatorcontrib><creatorcontrib>Jackman, H</creatorcontrib><creatorcontrib>Pscheidt, G</creatorcontrib><creatorcontrib>Smith, M D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Schizophrenia bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meltzer, H Y</au><au>Arora, R C</au><au>Jackman, H</au><au>Pscheidt, G</au><au>Smith, M D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet monoamine oxidase and plasma amine oxidase in psychiatric patients</atitle><jtitle>Schizophrenia bulletin</jtitle><addtitle>Schizophr Bull</addtitle><date>1980</date><risdate>1980</risdate><volume>6</volume><issue>2</issue><spage>213</spage><epage>219</epage><pages>213-219</pages><issn>0586-7614</issn><eissn>1745-1701</eissn><abstract>Platelet monoamine oxidase (MAO) and plasma amine oxidase (PAO) activities were determined in 70 normal controls and 76 psychiatric patients. Platelet MAO activity did not differ between the normal controls and patients diagnosed as schizophrenic or primary affective illness, although there was a strong trend for chronic schizophrenics to have lower MAO activity. Schizophrenic patients with Schneiderian-type hallucinatiions had significantly lower MAO activity than normal controls or schizophrenic patients who did not hallucinate. There was no relationship between hallucinations and platelet MAO activity in patients with affective psychoses. Paranoid schizophrenics did not have significantly different MAO activity from nonparanoid schizophrenics. PAO activity was generally lower in all diagnostic groups than in normal controls, but the results were statistically significant only for acute schizophrenics.</abstract><cop>United States</cop><pub>National Institute of Mental Health</pub><pmid>7375852</pmid><doi>10.1093/schbul/6.2.213</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0586-7614 |
| ispartof | Schizophrenia bulletin, 1980, Vol.6 (2), p.213-219 |
| issn | 0586-7614 1745-1701 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; EBSCOhost APA PsycARTICLES; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acute Schizophrenia Affective Disorders, Psychotic - enzymology Bipolar Disorder - enzymology Blood Plasma Blood Platelets Blood Platelets - enzymology Etiology Female Hallucinations - enzymology Human Humans Male Monoamine Oxidase - blood Monoamine Oxidases Oxidases Oxidoreductases Acting on CH-NH Group Donors - blood Paranoid Schizophrenia Schizophrenia Schizophrenia - enzymology Schizophrenia, Paranoid - enzymology |
| title | Platelet monoamine oxidase and plasma amine oxidase in psychiatric patients |
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