Evidence that somatostatin inhibits proinsulin synthesis and insulin release by isolated pancreatic islets of the rat

Conflicting reports on the direction and magnitude of the effect of somatostatin on (pro)insulin synthesis prompted our investigation. Two assays for proinsulin synthesis were designed in which [4,5- 3H]-L-leucine incorporation into proinsulin was normalized on the basis of postincubation insulin le...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 1980-04, Vol.29 (4), p.351-354
Hauptverfasser:	Williams, Frank G., Bauer, G.Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Glucagon - pharmacology Glucose - pharmacology In Vitro Techniques Insulin - metabolism Insulin Secretion Islets of Langerhans - metabolism Male Proinsulin - biosynthesis Rats Somatostatin - pharmacology
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