Use of a common standard for comparison of insulin C-peptide measurements by different laboratories

A synthetic human C-peptide analogue has been used as a common standard for the comparison of insulin C-peptide measurements in seven assay systems in six laboratories. Even in terms of this common standard there was statistically significant numerical heterogeneity between laboratories for estimate...

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Veröffentlicht in:	Diabetologia 1980-03, Vol.18 (3), p.197-204
Hauptverfasser:	Caygill, C P, Gaines Das, R E, Bangham, D R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma, Islet Cell - blood C-Peptide - analogs & derivatives C-Peptide - blood Diabetes Mellitus - blood Humans Pancreatic Neoplasms - blood Peptides - blood Proinsulin - blood Quality Control Radioimmunoassay - methods
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container_title	Diabetologia
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creator	Caygill, C P Gaines Das, R E Bangham, D R
description	A synthetic human C-peptide analogue has been used as a common standard for the comparison of insulin C-peptide measurements in seven assay systems in six laboratories. Even in terms of this common standard there was statistically significant numerical heterogeneity between laboratories for estimates of the C-peptide content of the same plasma samples. However, the consistency in ranking order of estimates of C-peptide in the plasma samples between laboratories suggests that laboratories are in most cases measuring at least similar immunoreactive constituents and that a reference plasma might prove useful in comparing results between laboratories. Until a more suitable reference material is available, the synthetic analogue, 64 formyllysine C-peptide, in ampoules coded 76/561, will be made available for research purposes.
doi_str_mv	10.1007/BF00251916
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Even in terms of this common standard there was statistically significant numerical heterogeneity between laboratories for estimates of the C-peptide content of the same plasma samples. However, the consistency in ranking order of estimates of C-peptide in the plasma samples between laboratories suggests that laboratories are in most cases measuring at least similar immunoreactive constituents and that a reference plasma might prove useful in comparing results between laboratories. Until a more suitable reference material is available, the synthetic analogue, 64 formyllysine C-peptide, in ampoules coded 76/561, will be made available for research purposes.</description><subject>Adenoma, Islet Cell - blood</subject><subject>C-Peptide - analogs & derivatives</subject><subject>C-Peptide - blood</subject><subject>Diabetes Mellitus - blood</subject><subject>Humans</subject><subject>Pancreatic Neoplasms - blood</subject><subject>Peptides - blood</subject><subject>Proinsulin - blood</subject><subject>Quality Control</subject><subject>Radioimmunoassay - methods</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLxDAURoMo4zi6cS9k5UKo5tW0XergqDDgxgF3JY8biDRNTdqF_94OM-jqcg-Hb3EQuqbknhJSPTxtCGElbag8QUsqOCuIYPUpWhJCWUFr-XmOLnL-IoTwUsgFWkgmyqbmS2R2GXB0WGETQ4g9zqPqrUoWu5j2bFDJ55nPju_z1Pker4sBhtFbwAFUnhIE6MeM9Q-23jlI84c7pWNSY0we8iU6c6rLcHW8K7TbPH-sX4vt-8vb-nFbGE7rsbBCM10JYrnhlTCyUdrVtBTMNpXhIEoKnDmjpDGaGWUlZaWzlTYzZlATvkK3h90hxe8J8tgGnw10neohTrmtSkoo53IW7w6iSTHnBK4dkg8q_bSUtPui7X_RWb45rk46gP1Tjwn5L6urce8</recordid><startdate>198003</startdate><enddate>198003</enddate><creator>Caygill, C P</creator><creator>Gaines Das, R E</creator><creator>Bangham, D R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198003</creationdate><title>Use of a common standard for comparison of insulin C-peptide measurements by different laboratories</title><author>Caygill, C P ; Gaines Das, R E ; Bangham, D R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c318t-d4b2b740d3c374c69abf81542d97c3e451e32fca6ccb2cad6125fd7bce322e803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Adenoma, Islet Cell - blood</topic><topic>C-Peptide - analogs & derivatives</topic><topic>C-Peptide - blood</topic><topic>Diabetes Mellitus - blood</topic><topic>Humans</topic><topic>Pancreatic Neoplasms - blood</topic><topic>Peptides - blood</topic><topic>Proinsulin - blood</topic><topic>Quality Control</topic><topic>Radioimmunoassay - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caygill, C P</creatorcontrib><creatorcontrib>Gaines Das, R E</creatorcontrib><creatorcontrib>Bangham, D R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caygill, C P</au><au>Gaines Das, R E</au><au>Bangham, D R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of a common standard for comparison of insulin C-peptide measurements by different laboratories</atitle><jtitle>Diabetologia</jtitle><addtitle>Diabetologia</addtitle><date>1980-03</date><risdate>1980</risdate><volume>18</volume><issue>3</issue><spage>197</spage><epage>204</epage><pages>197-204</pages><issn>0012-186X</issn><eissn>1432-0428</eissn><abstract>A synthetic human C-peptide analogue has been used as a common standard for the comparison of insulin C-peptide measurements in seven assay systems in six laboratories. 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source	MEDLINE; SpringerNature Journals
subjects	Adenoma, Islet Cell - blood C-Peptide - analogs & derivatives C-Peptide - blood Diabetes Mellitus - blood Humans Pancreatic Neoplasms - blood Peptides - blood Proinsulin - blood Quality Control Radioimmunoassay - methods
title	Use of a common standard for comparison of insulin C-peptide measurements by different laboratories
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