Transmission of the Hepatitis B Virus-Associated Delta Antigen to Chimpanzees
Inoculation of hepatitis B surface antigen (HBsAg)-positive sera from patients with chronic liver disease and intrahepatic delta (δ) into chimpanzees susceptible to infection with hepatitis B virus (HBV) resulted in type B hepatitis and δ markers (δ antigen and antibody to δ) in recipient animals. A...
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| Veröffentlicht in: | The Journal of infectious diseases 1980-05, Vol.141 (5), p.590-602 |
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| container_issue | 5 |
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| container_title | The Journal of infectious diseases |
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| creator | Rizzetto, M. Canese, M. G. Gerin, J. L. London, W. T. Sly, D. L. Purcell, R. H. |
| description | Inoculation of hepatitis B surface antigen (HBsAg)-positive sera from patients with chronic liver disease and intrahepatic delta (δ) into chimpanzees susceptible to infection with hepatitis B virus (HBV) resulted in type B hepatitis and δ markers (δ antigen and antibody to δ) in recipient animals. A dilution (10-8) of serum induced type B hepatitis without δ markers in another HBV-susceptible animal. HBV infection and δ markers did not develop in animals with preexisting titers of antibody to HBsAg. In chimpanzees with circulating HBsAg at the time of inoculation, synthesis of d occurred earlier and its extent and duration were greater than in animals previously unexposed to HBV; coincident with synthesis of δ, hepatitis occurred in chronic HBsAg carriers, and synthesis of preexisting HBV gene products (HBsAg and hepatitis B core antigen) was diminished. Delta appears to be a marker of a transmissible pathogenic agent, either an HBV variant or another agent that requires the helper functions of HBV, that is defective and interferes with HBV replication. |
| doi_str_mv | 10.1093/infdis/141.5.590 |
| format | Article |
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G. ; Gerin, J. L. ; London, W. T. ; Sly, D. L. ; Purcell, R. H.</creator><creatorcontrib>Rizzetto, M. ; Canese, M. G. ; Gerin, J. L. ; London, W. T. ; Sly, D. L. ; Purcell, R. H.</creatorcontrib><description>Inoculation of hepatitis B surface antigen (HBsAg)-positive sera from patients with chronic liver disease and intrahepatic delta (δ) into chimpanzees susceptible to infection with hepatitis B virus (HBV) resulted in type B hepatitis and δ markers (δ antigen and antibody to δ) in recipient animals. A dilution (10-8) of serum induced type B hepatitis without δ markers in another HBV-susceptible animal. HBV infection and δ markers did not develop in animals with preexisting titers of antibody to HBsAg. In chimpanzees with circulating HBsAg at the time of inoculation, synthesis of d occurred earlier and its extent and duration were greater than in animals previously unexposed to HBV; coincident with synthesis of δ, hepatitis occurred in chronic HBsAg carriers, and synthesis of preexisting HBV gene products (HBsAg and hepatitis B core antigen) was diminished. Delta appears to be a marker of a transmissible pathogenic agent, either an HBV variant or another agent that requires the helper functions of HBV, that is defective and interferes with HBV replication.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/141.5.590</identifier><identifier>PMID: 6989929</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Animals ; Antibodies ; Antigens ; Biopsies ; DNA-Directed DNA Polymerase - metabolism ; Fluorescent Antibody Technique ; Hepatitis ; Hepatitis antigens ; Hepatitis B - transmission ; Hepatitis B Antigens - administration & dosage ; Hepatitis B Surface Antigens - administration & dosage ; Hepatitis B virus ; Humans ; Infections ; Inoculation ; Liver ; Liver - microbiology ; Liver - ultrastructure ; Microscopy, Electron ; Pan troglodytes ; Radioimmunoassay ; Viral Infections and Antiviral Theraphy</subject><ispartof>The Journal of infectious diseases, 1980-05, Vol.141 (5), p.590-602</ispartof><rights>Copyright 1980 The University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-90c9923d6ac96a4414fa8b72627664c7b12b7a9cc86715b2d2a5aca78edc53e43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30109869$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30109869$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6989929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rizzetto, M.</creatorcontrib><creatorcontrib>Canese, M. G.</creatorcontrib><creatorcontrib>Gerin, J. L.</creatorcontrib><creatorcontrib>London, W. T.</creatorcontrib><creatorcontrib>Sly, D. L.</creatorcontrib><creatorcontrib>Purcell, R. H.</creatorcontrib><title>Transmission of the Hepatitis B Virus-Associated Delta Antigen to Chimpanzees</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Inoculation of hepatitis B surface antigen (HBsAg)-positive sera from patients with chronic liver disease and intrahepatic delta (δ) into chimpanzees susceptible to infection with hepatitis B virus (HBV) resulted in type B hepatitis and δ markers (δ antigen and antibody to δ) in recipient animals. A dilution (10-8) of serum induced type B hepatitis without δ markers in another HBV-susceptible animal. HBV infection and δ markers did not develop in animals with preexisting titers of antibody to HBsAg. In chimpanzees with circulating HBsAg at the time of inoculation, synthesis of d occurred earlier and its extent and duration were greater than in animals previously unexposed to HBV; coincident with synthesis of δ, hepatitis occurred in chronic HBsAg carriers, and synthesis of preexisting HBV gene products (HBsAg and hepatitis B core antigen) was diminished. Delta appears to be a marker of a transmissible pathogenic agent, either an HBV variant or another agent that requires the helper functions of HBV, that is defective and interferes with HBV replication.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Biopsies</subject><subject>DNA-Directed DNA Polymerase - metabolism</subject><subject>Fluorescent Antibody Technique</subject><subject>Hepatitis</subject><subject>Hepatitis antigens</subject><subject>Hepatitis B - transmission</subject><subject>Hepatitis B Antigens - administration & dosage</subject><subject>Hepatitis B Surface Antigens - administration & dosage</subject><subject>Hepatitis B virus</subject><subject>Humans</subject><subject>Infections</subject><subject>Inoculation</subject><subject>Liver</subject><subject>Liver - microbiology</subject><subject>Liver - ultrastructure</subject><subject>Microscopy, Electron</subject><subject>Pan troglodytes</subject><subject>Radioimmunoassay</subject><subject>Viral Infections and Antiviral Theraphy</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkLtPwzAQhy0EKuWxsyB5YkvxI7bjsS2PgkAsgBCL5TgOdWmT4nMl4K8nVasynXTf7-50H0JnlAwo0fwyNHUV4JLmdCAGQpM91KeCq0xKyvdRnxDGMlpofYiOAGaEkJxL1UM9qbsm0330-BxtA4sAENoGtzVOU48nfmlTSAHwCL-GuIJsCNC6YJOv8JWfJ4uHTQofvsGpxeNpWCxt8-s9nKCD2s7Bn27rMXq5uX4eT7KHp9u78fAhc1ywlGniuuu8ktZpafOc5rUtSsUkU1LmTpWUlcpq5wqpqChZxaywzqrCV05wn_NjdLHZu4zt18pDMt0Hzs_ntvHtCowSlFCi1kGyCbrYAkRfm2UMCxt_DCVmbdBsDJrOoBGmM9iNnG93r8qFr3YDW2X_fAapjTvMu4O6kGuebXiA5L933MZPIxVXwkze3s291G9E3RRmxP8A-RuGMw</recordid><startdate>198005</startdate><enddate>198005</enddate><creator>Rizzetto, M.</creator><creator>Canese, M. G.</creator><creator>Gerin, J. L.</creator><creator>London, W. T.</creator><creator>Sly, D. L.</creator><creator>Purcell, R. H.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198005</creationdate><title>Transmission of the Hepatitis B Virus-Associated Delta Antigen to Chimpanzees</title><author>Rizzetto, M. ; Canese, M. G. ; Gerin, J. L. ; London, W. T. ; Sly, D. L. ; Purcell, R. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-90c9923d6ac96a4414fa8b72627664c7b12b7a9cc86715b2d2a5aca78edc53e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>Biopsies</topic><topic>DNA-Directed DNA Polymerase - metabolism</topic><topic>Fluorescent Antibody Technique</topic><topic>Hepatitis</topic><topic>Hepatitis antigens</topic><topic>Hepatitis B - transmission</topic><topic>Hepatitis B Antigens - administration & dosage</topic><topic>Hepatitis B Surface Antigens - administration & dosage</topic><topic>Hepatitis B virus</topic><topic>Humans</topic><topic>Infections</topic><topic>Inoculation</topic><topic>Liver</topic><topic>Liver - microbiology</topic><topic>Liver - ultrastructure</topic><topic>Microscopy, Electron</topic><topic>Pan troglodytes</topic><topic>Radioimmunoassay</topic><topic>Viral Infections and Antiviral Theraphy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rizzetto, M.</creatorcontrib><creatorcontrib>Canese, M. G.</creatorcontrib><creatorcontrib>Gerin, J. L.</creatorcontrib><creatorcontrib>London, W. T.</creatorcontrib><creatorcontrib>Sly, D. L.</creatorcontrib><creatorcontrib>Purcell, R. H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rizzetto, M.</au><au>Canese, M. G.</au><au>Gerin, J. L.</au><au>London, W. T.</au><au>Sly, D. L.</au><au>Purcell, R. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transmission of the Hepatitis B Virus-Associated Delta Antigen to Chimpanzees</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1980-05</date><risdate>1980</risdate><volume>141</volume><issue>5</issue><spage>590</spage><epage>602</epage><pages>590-602</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Inoculation of hepatitis B surface antigen (HBsAg)-positive sera from patients with chronic liver disease and intrahepatic delta (δ) into chimpanzees susceptible to infection with hepatitis B virus (HBV) resulted in type B hepatitis and δ markers (δ antigen and antibody to δ) in recipient animals. A dilution (10-8) of serum induced type B hepatitis without δ markers in another HBV-susceptible animal. HBV infection and δ markers did not develop in animals with preexisting titers of antibody to HBsAg. In chimpanzees with circulating HBsAg at the time of inoculation, synthesis of d occurred earlier and its extent and duration were greater than in animals previously unexposed to HBV; coincident with synthesis of δ, hepatitis occurred in chronic HBsAg carriers, and synthesis of preexisting HBV gene products (HBsAg and hepatitis B core antigen) was diminished. Delta appears to be a marker of a transmissible pathogenic agent, either an HBV variant or another agent that requires the helper functions of HBV, that is defective and interferes with HBV replication.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>6989929</pmid><doi>10.1093/infdis/141.5.590</doi><tpages>13</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1980-05, Vol.141 (5), p.590-602 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Animals Antibodies Antigens Biopsies DNA-Directed DNA Polymerase - metabolism Fluorescent Antibody Technique Hepatitis Hepatitis antigens Hepatitis B - transmission Hepatitis B Antigens - administration & dosage Hepatitis B Surface Antigens - administration & dosage Hepatitis B virus Humans Infections Inoculation Liver Liver - microbiology Liver - ultrastructure Microscopy, Electron Pan troglodytes Radioimmunoassay Viral Infections and Antiviral Theraphy |
| title | Transmission of the Hepatitis B Virus-Associated Delta Antigen to Chimpanzees |
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