Adriamycin and hydroxyurea as radiopotentiators in the treatment of squamous cell carcinoma of the cervix implanted in nude mice: A preliminary report
A tumor model using human squamous cell carcinoma of the cervix implanted in nude mice was developed. Hydroxyurea and Adriamycin were used as radiopotentiators. A regression delay was observed in tumors treated with radiation therapy alone and radiation therapy and Hydroxyurea. No regression delay w...
Gespeichert in:
| Veröffentlicht in: | Gynecologic oncology 1980-04, Vol.9 (2), p.170-176 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 176 |
|---|---|
| container_issue | 2 |
| container_start_page | 170 |
| container_title | Gynecologic oncology |
| container_volume | 9 |
| creator | Xynos, Francisco P. Benjamin, Ivy Sapiente, Ronald Rana, M.Waheed Nalesnik, William J. |
| description | A tumor model using human squamous cell carcinoma of the cervix implanted in nude mice was developed. Hydroxyurea and Adriamycin were used as radiopotentiators. A regression delay was observed in tumors treated with radiation therapy alone and radiation therapy and Hydroxyurea. No regression delay was observed when the tumors were treated with radiation therapy and Adriamycin. Six weeks after treatment, 75% of the tumors treated with radiation therapy and Adriamycin were not palpable, while all the tumors were present in the group treated with radiation therapy alone and radiation therapy and Hydroxyurea. No difference in tumor response was noted between the group receiving radiation therapy alone and radiation therapy and Hydroxyurea. This preliminary observation shows obvious interaction between Adriamycin and radiation therapy, suggesting radiopotentiating activity. The tumor model was found useful and practical. |
| doi_str_mv | 10.1016/0090-8258(80)90024-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75099144</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0090825880900244</els_id><sourcerecordid>75099144</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-ce98de22c1d5df12b151980197dfea2892a91876fee4b276fb0c8e8ddb4ca2233</originalsourceid><addsrcrecordid>eNp9kcFq3DAQhkVpSTZp36AFnUpycDuS7bWUQ2AJTVsI9NKehSyNiYplOZIcsi-S563cXXLMaUD_N7_mnyHkI4MvDNj2K4CESvBWXAi4lAC8qZo3ZMNAttVWtPIt2bwgp-Qspb8AUAPjJ-SkqzvOhNyQ552NTvu9cRPVk6X3exvD036JqKlONGrrwhwyTtnpHGKihcv3SHMBsi_PNAw0PSzahyVRg-NIjY7FLXi9SitrMD66J-r8POopo109psUi9c7gFd3ROeLovJt03NOIc4j5PXk36DHhh2M9J39uv_2--VHd_fr-82Z3V5m67XJlUAqLnBtmWzsw3rOWSQFMdnZAzYXkWjLRbQfEpuel9mAECmv7xmjO6_qcfD74zjE8LJiy8i6tKfSEJZDqWpCSNU0BmwNoYkgp4qDm6HwZWDFQ6znUumu17loJUP_Poda2T0f_pfdoX5qO-y_69UHHEvLRYVTJOJwMWhfRZGWDe_2Df8ienXM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75099144</pqid></control><display><type>article</type><title>Adriamycin and hydroxyurea as radiopotentiators in the treatment of squamous cell carcinoma of the cervix implanted in nude mice: A preliminary report</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Xynos, Francisco P. ; Benjamin, Ivy ; Sapiente, Ronald ; Rana, M.Waheed ; Nalesnik, William J.</creator><creatorcontrib>Xynos, Francisco P. ; Benjamin, Ivy ; Sapiente, Ronald ; Rana, M.Waheed ; Nalesnik, William J.</creatorcontrib><description>A tumor model using human squamous cell carcinoma of the cervix implanted in nude mice was developed. Hydroxyurea and Adriamycin were used as radiopotentiators. A regression delay was observed in tumors treated with radiation therapy alone and radiation therapy and Hydroxyurea. No regression delay was observed when the tumors were treated with radiation therapy and Adriamycin. Six weeks after treatment, 75% of the tumors treated with radiation therapy and Adriamycin were not palpable, while all the tumors were present in the group treated with radiation therapy alone and radiation therapy and Hydroxyurea. No difference in tumor response was noted between the group receiving radiation therapy alone and radiation therapy and Hydroxyurea. This preliminary observation shows obvious interaction between Adriamycin and radiation therapy, suggesting radiopotentiating activity. The tumor model was found useful and practical.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1016/0090-8258(80)90024-4</identifier><identifier>PMID: 7372189</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Carcinoma, Squamous Cell - drug therapy ; Carcinoma, Squamous Cell - radiotherapy ; Carcinoma, Squamous Cell - therapy ; Doxorubicin - therapeutic use ; Female ; Humans ; Hydroxyurea - therapeutic use ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Radiation-Sensitizing Agents - therapeutic use ; Uterine Cervical Neoplasms - drug therapy ; Uterine Cervical Neoplasms - radiotherapy ; Uterine Cervical Neoplasms - therapy</subject><ispartof>Gynecologic oncology, 1980-04, Vol.9 (2), p.170-176</ispartof><rights>1980</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-ce98de22c1d5df12b151980197dfea2892a91876fee4b276fb0c8e8ddb4ca2233</citedby><cites>FETCH-LOGICAL-c357t-ce98de22c1d5df12b151980197dfea2892a91876fee4b276fb0c8e8ddb4ca2233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0090-8258(80)90024-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7372189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xynos, Francisco P.</creatorcontrib><creatorcontrib>Benjamin, Ivy</creatorcontrib><creatorcontrib>Sapiente, Ronald</creatorcontrib><creatorcontrib>Rana, M.Waheed</creatorcontrib><creatorcontrib>Nalesnik, William J.</creatorcontrib><title>Adriamycin and hydroxyurea as radiopotentiators in the treatment of squamous cell carcinoma of the cervix implanted in nude mice: A preliminary report</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>A tumor model using human squamous cell carcinoma of the cervix implanted in nude mice was developed. Hydroxyurea and Adriamycin were used as radiopotentiators. A regression delay was observed in tumors treated with radiation therapy alone and radiation therapy and Hydroxyurea. No regression delay was observed when the tumors were treated with radiation therapy and Adriamycin. Six weeks after treatment, 75% of the tumors treated with radiation therapy and Adriamycin were not palpable, while all the tumors were present in the group treated with radiation therapy alone and radiation therapy and Hydroxyurea. No difference in tumor response was noted between the group receiving radiation therapy alone and radiation therapy and Hydroxyurea. This preliminary observation shows obvious interaction between Adriamycin and radiation therapy, suggesting radiopotentiating activity. The tumor model was found useful and practical.</description><subject>Animals</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Doxorubicin - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Hydroxyurea - therapeutic use</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Neoplasm Transplantation</subject><subject>Radiation-Sensitizing Agents - therapeutic use</subject><subject>Uterine Cervical Neoplasms - drug therapy</subject><subject>Uterine Cervical Neoplasms - radiotherapy</subject><subject>Uterine Cervical Neoplasms - therapy</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFq3DAQhkVpSTZp36AFnUpycDuS7bWUQ2AJTVsI9NKehSyNiYplOZIcsi-S563cXXLMaUD_N7_mnyHkI4MvDNj2K4CESvBWXAi4lAC8qZo3ZMNAttVWtPIt2bwgp-Qspb8AUAPjJ-SkqzvOhNyQ552NTvu9cRPVk6X3exvD036JqKlONGrrwhwyTtnpHGKihcv3SHMBsi_PNAw0PSzahyVRg-NIjY7FLXi9SitrMD66J-r8POopo109psUi9c7gFd3ROeLovJt03NOIc4j5PXk36DHhh2M9J39uv_2--VHd_fr-82Z3V5m67XJlUAqLnBtmWzsw3rOWSQFMdnZAzYXkWjLRbQfEpuel9mAECmv7xmjO6_qcfD74zjE8LJiy8i6tKfSEJZDqWpCSNU0BmwNoYkgp4qDm6HwZWDFQ6znUumu17loJUP_Poda2T0f_pfdoX5qO-y_69UHHEvLRYVTJOJwMWhfRZGWDe_2Df8ienXM</recordid><startdate>198004</startdate><enddate>198004</enddate><creator>Xynos, Francisco P.</creator><creator>Benjamin, Ivy</creator><creator>Sapiente, Ronald</creator><creator>Rana, M.Waheed</creator><creator>Nalesnik, William J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198004</creationdate><title>Adriamycin and hydroxyurea as radiopotentiators in the treatment of squamous cell carcinoma of the cervix implanted in nude mice: A preliminary report</title><author>Xynos, Francisco P. ; Benjamin, Ivy ; Sapiente, Ronald ; Rana, M.Waheed ; Nalesnik, William J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-ce98de22c1d5df12b151980197dfea2892a91876fee4b276fb0c8e8ddb4ca2233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Doxorubicin - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Hydroxyurea - therapeutic use</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Neoplasm Transplantation</topic><topic>Radiation-Sensitizing Agents - therapeutic use</topic><topic>Uterine Cervical Neoplasms - drug therapy</topic><topic>Uterine Cervical Neoplasms - radiotherapy</topic><topic>Uterine Cervical Neoplasms - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xynos, Francisco P.</creatorcontrib><creatorcontrib>Benjamin, Ivy</creatorcontrib><creatorcontrib>Sapiente, Ronald</creatorcontrib><creatorcontrib>Rana, M.Waheed</creatorcontrib><creatorcontrib>Nalesnik, William J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xynos, Francisco P.</au><au>Benjamin, Ivy</au><au>Sapiente, Ronald</au><au>Rana, M.Waheed</au><au>Nalesnik, William J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adriamycin and hydroxyurea as radiopotentiators in the treatment of squamous cell carcinoma of the cervix implanted in nude mice: A preliminary report</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>1980-04</date><risdate>1980</risdate><volume>9</volume><issue>2</issue><spage>170</spage><epage>176</epage><pages>170-176</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><abstract>A tumor model using human squamous cell carcinoma of the cervix implanted in nude mice was developed. Hydroxyurea and Adriamycin were used as radiopotentiators. A regression delay was observed in tumors treated with radiation therapy alone and radiation therapy and Hydroxyurea. No regression delay was observed when the tumors were treated with radiation therapy and Adriamycin. Six weeks after treatment, 75% of the tumors treated with radiation therapy and Adriamycin were not palpable, while all the tumors were present in the group treated with radiation therapy alone and radiation therapy and Hydroxyurea. No difference in tumor response was noted between the group receiving radiation therapy alone and radiation therapy and Hydroxyurea. This preliminary observation shows obvious interaction between Adriamycin and radiation therapy, suggesting radiopotentiating activity. The tumor model was found useful and practical.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7372189</pmid><doi>10.1016/0090-8258(80)90024-4</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-8258 |
| ispartof | Gynecologic oncology, 1980-04, Vol.9 (2), p.170-176 |
| issn | 0090-8258 1095-6859 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75099144 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - therapy Doxorubicin - therapeutic use Female Humans Hydroxyurea - therapeutic use Mice Mice, Nude Neoplasm Transplantation Radiation-Sensitizing Agents - therapeutic use Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - radiotherapy Uterine Cervical Neoplasms - therapy |
| title | Adriamycin and hydroxyurea as radiopotentiators in the treatment of squamous cell carcinoma of the cervix implanted in nude mice: A preliminary report |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T20%3A43%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adriamycin%20and%20hydroxyurea%20as%20radiopotentiators%20in%20the%20treatment%20of%20squamous%20cell%20carcinoma%20of%20the%20cervix%20implanted%20in%20nude%20mice:%20A%20preliminary%20report&rft.jtitle=Gynecologic%20oncology&rft.au=Xynos,%20Francisco%20P.&rft.date=1980-04&rft.volume=9&rft.issue=2&rft.spage=170&rft.epage=176&rft.pages=170-176&rft.issn=0090-8258&rft.eissn=1095-6859&rft_id=info:doi/10.1016/0090-8258(80)90024-4&rft_dat=%3Cproquest_cross%3E75099144%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75099144&rft_id=info:pmid/7372189&rft_els_id=0090825880900244&rfr_iscdi=true |