Comparison of DNA distributions in primary human breast cancers and their metastases
Quantitative measurements of nuclear DNA in individual cells were performed on fine-needle aspirates from 22 primary breast tumors and their metastases, found either at operation or as much as 126 months afterwards. The DNA distribution patterns of each tumor differed widely. However, the primary tu...
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| Veröffentlicht in: | European journal of cancer 1980-02, Vol.16 (2), p.273-278 |
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| container_title | European journal of cancer |
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| creator | Auer, Gert U. Arrhenius, Eva Granberg, Per-Ola Fox, Cecil H. |
| description | Quantitative measurements of nuclear DNA in individual cells were performed on fine-needle aspirates from
22 primary breast tumors and their metastases, found either at operation or as much as
126 months afterwards. The DNA distribution patterns of each tumor differed widely. However, the primary tumor and its metastasis always showed similar distribution patterns, irrespective of location or time of occurrence of the metastasis. These results indicate a monoclonal genesis of breast carcinoma. It is suggested that the primary tumor and its metastases are made up of similar cell populations with comparable proliferative activities, which may be information of great importance for diagnosis and treatment of secondary breast malignancies. |
| doi_str_mv | 10.1016/0014-2964(80)90160-7 |
| format | Article |
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22 primary breast tumors and their metastases, found either at operation or as much as
126 months afterwards. The DNA distribution patterns of each tumor differed widely. However, the primary tumor and its metastasis always showed similar distribution patterns, irrespective of location or time of occurrence of the metastasis. These results indicate a monoclonal genesis of breast carcinoma. It is suggested that the primary tumor and its metastases are made up of similar cell populations with comparable proliferative activities, which may be information of great importance for diagnosis and treatment of secondary breast malignancies.</description><identifier>ISSN: 0014-2964</identifier><identifier>DOI: 10.1016/0014-2964(80)90160-7</identifier><identifier>PMID: 7371682</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Breast Neoplasms - metabolism ; Cell Count ; DNA, Neoplasm - metabolism ; Female ; Humans ; Lymphatic Metastasis ; Neoplasm Metastasis ; Neoplasm Recurrence, Local - metabolism ; Time Factors</subject><ispartof>European journal of cancer, 1980-02, Vol.16 (2), p.273-278</ispartof><rights>1980</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-be62a987a6501335d69df2cfe7bdd79e622618f0b4da6cbc5b1f7129440c35d33</citedby><cites>FETCH-LOGICAL-c357t-be62a987a6501335d69df2cfe7bdd79e622618f0b4da6cbc5b1f7129440c35d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7371682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Auer, Gert U.</creatorcontrib><creatorcontrib>Arrhenius, Eva</creatorcontrib><creatorcontrib>Granberg, Per-Ola</creatorcontrib><creatorcontrib>Fox, Cecil H.</creatorcontrib><title>Comparison of DNA distributions in primary human breast cancers and their metastases</title><title>European journal of cancer</title><addtitle>Eur J Cancer</addtitle><description>Quantitative measurements of nuclear DNA in individual cells were performed on fine-needle aspirates from
22 primary breast tumors and their metastases, found either at operation or as much as
126 months afterwards. The DNA distribution patterns of each tumor differed widely. However, the primary tumor and its metastasis always showed similar distribution patterns, irrespective of location or time of occurrence of the metastasis. These results indicate a monoclonal genesis of breast carcinoma. It is suggested that the primary tumor and its metastases are made up of similar cell populations with comparable proliferative activities, which may be information of great importance for diagnosis and treatment of secondary breast malignancies.</description><subject>Breast Neoplasms - metabolism</subject><subject>Cell Count</subject><subject>DNA, Neoplasm - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Recurrence, Local - metabolism</subject><subject>Time Factors</subject><issn>0014-2964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPwzAQhH0AlVL4ByD5hOAQsJ3ETi5IVXlKFVzK2fJjoxo1SbEdJP49Lo165LTSzO6s5kPogpJbSii_I4QWGat5cV2RmzopJBNHaHqQT9BpCJ-EsKoo2QRNRC4or9gUrRZ9u1Xehb7DfYMf3ubYuhC900N0fRew6_DWu1b5H7weWtVh7UGFiI3qDPiAVWdxXIPzuIWYDBUgnKHjRm0CnI9zhj6eHleLl2z5_vy6mC8zk5ciZho4U3UlFC8JzfPS8to2zDQgtLWiTi7jtGqILqziRptS00ZQVhcFSQE2z2foap-79f3XACHK1gUDm43qoB-CFCWpBcvLtFjsF43vQ_DQyLGTpETuAModKbkjJSsi_wBKkc4ux_xBt2APRyO95N_vfUglvx14GYyDxMU6DyZK27v_H_wChemB-Q</recordid><startdate>198002</startdate><enddate>198002</enddate><creator>Auer, Gert U.</creator><creator>Arrhenius, Eva</creator><creator>Granberg, Per-Ola</creator><creator>Fox, Cecil H.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198002</creationdate><title>Comparison of DNA distributions in primary human breast cancers and their metastases</title><author>Auer, Gert U. ; Arrhenius, Eva ; Granberg, Per-Ola ; Fox, Cecil H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-be62a987a6501335d69df2cfe7bdd79e622618f0b4da6cbc5b1f7129440c35d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Breast Neoplasms - metabolism</topic><topic>Cell Count</topic><topic>DNA, Neoplasm - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Recurrence, Local - metabolism</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Auer, Gert U.</creatorcontrib><creatorcontrib>Arrhenius, Eva</creatorcontrib><creatorcontrib>Granberg, Per-Ola</creatorcontrib><creatorcontrib>Fox, Cecil H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Auer, Gert U.</au><au>Arrhenius, Eva</au><au>Granberg, Per-Ola</au><au>Fox, Cecil H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of DNA distributions in primary human breast cancers and their metastases</atitle><jtitle>European journal of cancer</jtitle><addtitle>Eur J Cancer</addtitle><date>1980-02</date><risdate>1980</risdate><volume>16</volume><issue>2</issue><spage>273</spage><epage>278</epage><pages>273-278</pages><issn>0014-2964</issn><abstract>Quantitative measurements of nuclear DNA in individual cells were performed on fine-needle aspirates from
22 primary breast tumors and their metastases, found either at operation or as much as
126 months afterwards. The DNA distribution patterns of each tumor differed widely. However, the primary tumor and its metastasis always showed similar distribution patterns, irrespective of location or time of occurrence of the metastasis. These results indicate a monoclonal genesis of breast carcinoma. It is suggested that the primary tumor and its metastases are made up of similar cell populations with comparable proliferative activities, which may be information of great importance for diagnosis and treatment of secondary breast malignancies.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>7371682</pmid><doi>10.1016/0014-2964(80)90160-7</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Breast Neoplasms - metabolism Cell Count DNA, Neoplasm - metabolism Female Humans Lymphatic Metastasis Neoplasm Metastasis Neoplasm Recurrence, Local - metabolism Time Factors |
| title | Comparison of DNA distributions in primary human breast cancers and their metastases |
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