Arachidonate metabolite(s) increase the permeability of the plasma membrane of the neutrophils to calcium
The relationship between arachidonate metabolism and stimulated calcium fluxes in rabbit peritoneal neutrophils has been investigated. The addition of arachidonate to the neutrophils was found to cause a rapid and significant increase in the permeability of the plasma membrane to calcium. This effec...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1980-02, Vol.92 (4), p.1231-1237 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Volpi, M. Naccache, P.H. Sha'afi, R.I. |
| description | The relationship between arachidonate metabolism and stimulated calcium fluxes in rabbit peritoneal neutrophils has been investigated. The addition of arachidonate to the neutrophils was found to cause a rapid and significant increase in the permeability of the plasma membrane to calcium. This effect is specific to calcium, concentration dependent and sensitive to inhibitors of the lipoxygenase mediated metabolic pathway(s). These results strongly suggest that arachidonate metabolites are directly involved in the mechanisms underlying calcium gating in the neutrophils. |
| doi_str_mv | 10.1016/0006-291X(80)90418-0 |
| format | Article |
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The addition of arachidonate to the neutrophils was found to cause a rapid and significant increase in the permeability of the plasma membrane to calcium. This effect is specific to calcium, concentration dependent and sensitive to inhibitors of the lipoxygenase mediated metabolic pathway(s). These results strongly suggest that arachidonate metabolites are directly involved in the mechanisms underlying calcium gating in the neutrophils.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(80)90418-0</identifier><identifier>PMID: 7370031</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Arachidonic Acids - blood ; Arachidonic Acids - pharmacology ; Biological Transport, Active - drug effects ; Calcium - blood ; Catechols - pharmacology ; Cell Membrane - drug effects ; Cell Membrane - metabolism ; Kinetics ; Masoprocol ; Neutrophils - drug effects ; Neutrophils - metabolism ; Permeability ; Rabbits</subject><ispartof>Biochemical and biophysical research communications, 1980-02, Vol.92 (4), p.1231-1237</ispartof><rights>1980</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-3751fd11ffdc75bcb973761710772ca9dc38a4bb68d31d3f8a47d77d719666a83</citedby><cites>FETCH-LOGICAL-c357t-3751fd11ffdc75bcb973761710772ca9dc38a4bb68d31d3f8a47d77d719666a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-291X(80)90418-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7370031$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Volpi, M.</creatorcontrib><creatorcontrib>Naccache, P.H.</creatorcontrib><creatorcontrib>Sha'afi, R.I.</creatorcontrib><title>Arachidonate metabolite(s) increase the permeability of the plasma membrane of the neutrophils to calcium</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The relationship between arachidonate metabolism and stimulated calcium fluxes in rabbit peritoneal neutrophils has been investigated. The addition of arachidonate to the neutrophils was found to cause a rapid and significant increase in the permeability of the plasma membrane to calcium. This effect is specific to calcium, concentration dependent and sensitive to inhibitors of the lipoxygenase mediated metabolic pathway(s). These results strongly suggest that arachidonate metabolites are directly involved in the mechanisms underlying calcium gating in the neutrophils.</description><subject>Animals</subject><subject>Arachidonic Acids - blood</subject><subject>Arachidonic Acids - pharmacology</subject><subject>Biological Transport, Active - drug effects</subject><subject>Calcium - blood</subject><subject>Catechols - pharmacology</subject><subject>Cell Membrane - drug effects</subject><subject>Cell Membrane - metabolism</subject><subject>Kinetics</subject><subject>Masoprocol</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - metabolism</subject><subject>Permeability</subject><subject>Rabbits</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFLJDEQhYO46KzuP1Dok-ih16pJT9J9EWRwVRjYywreQjqpZiLdnTFJC_57MzujRyEQUu-9qsrH2BnCbwQU1wAgynmDz5c1XDVQYV3CAZshNFDOEapDNvuyHLOfMb4AIFaiOWJHkksAjjPmboM2a2f9qBMVAyXd-t4luoxXhRtNIB2pSGsqNhQG0q3L4nvhu12t13HQOTW0QY_0WR5pSsFv1q6PRfKF0b1x03DKfnS6j_Rrf5-wpz93_5YP5erv_ePydlUavpCp5HKBnUXsOmvkojVtk3cVKBGknBvdWMNrXbWtqC1Hy7v8kFbmg40QQtf8hF3s-m6Cf50oJjW4aKjv84Z-ikouoBEgeDZWO6MJPsZAndoEN-jwrhDUlrDa4lNbfKoG9Z-wghw73_ef2oHsV2iPNOs3O53yJ98cBRWNo9GQdYFMUta77wd8AAvwi6k</recordid><startdate>19800227</startdate><enddate>19800227</enddate><creator>Volpi, M.</creator><creator>Naccache, P.H.</creator><creator>Sha'afi, R.I.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19800227</creationdate><title>Arachidonate metabolite(s) increase the permeability of the plasma membrane of the neutrophils to calcium</title><author>Volpi, M. ; Naccache, P.H. ; Sha'afi, R.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-3751fd11ffdc75bcb973761710772ca9dc38a4bb68d31d3f8a47d77d719666a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Arachidonic Acids - blood</topic><topic>Arachidonic Acids - pharmacology</topic><topic>Biological Transport, Active - drug effects</topic><topic>Calcium - blood</topic><topic>Catechols - pharmacology</topic><topic>Cell Membrane - drug effects</topic><topic>Cell Membrane - metabolism</topic><topic>Kinetics</topic><topic>Masoprocol</topic><topic>Neutrophils - drug effects</topic><topic>Neutrophils - metabolism</topic><topic>Permeability</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Volpi, M.</creatorcontrib><creatorcontrib>Naccache, P.H.</creatorcontrib><creatorcontrib>Sha'afi, R.I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Volpi, M.</au><au>Naccache, P.H.</au><au>Sha'afi, R.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arachidonate metabolite(s) increase the permeability of the plasma membrane of the neutrophils to calcium</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1980-02-27</date><risdate>1980</risdate><volume>92</volume><issue>4</issue><spage>1231</spage><epage>1237</epage><pages>1231-1237</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>The relationship between arachidonate metabolism and stimulated calcium fluxes in rabbit peritoneal neutrophils has been investigated. The addition of arachidonate to the neutrophils was found to cause a rapid and significant increase in the permeability of the plasma membrane to calcium. This effect is specific to calcium, concentration dependent and sensitive to inhibitors of the lipoxygenase mediated metabolic pathway(s). These results strongly suggest that arachidonate metabolites are directly involved in the mechanisms underlying calcium gating in the neutrophils.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7370031</pmid><doi>10.1016/0006-291X(80)90418-0</doi><tpages>7</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1980-02, Vol.92 (4), p.1231-1237 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Arachidonic Acids - blood Arachidonic Acids - pharmacology Biological Transport, Active - drug effects Calcium - blood Catechols - pharmacology Cell Membrane - drug effects Cell Membrane - metabolism Kinetics Masoprocol Neutrophils - drug effects Neutrophils - metabolism Permeability Rabbits |
| title | Arachidonate metabolite(s) increase the permeability of the plasma membrane of the neutrophils to calcium |
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