The Crossover Experiment for Clinical Trials

The Crossover Experiment for Clinical Trials

The two-period crossover or changeover design for clinical trials is compared with other simple designs in terms of statistical precision and cost. The sensitivity of the crossover to bias due to carryover effects is examined. The feasibility of using the crossover data to test for the existence of...

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Veröffentlicht in:Biometrics 1980-03, Vol.36 (1), p.69-79
1. Verfasser: Brown, Jr, B W
Format: Artikel
Sprache:eng
Schlagworte:
Antianxiety agents
Biometrics
Clinical trials
Clinical Trials as Topic - economics
Clinical Trials as Topic - methods
Cost efficiency
Cost savings
Crossovers
Experiment design
Humans
Placebos
Probability
Random Allocation
Research Design
Statistical discrepancies
Unbiased estimators
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Zusammenfassung:The two-period crossover or changeover design for clinical trials is compared with other simple designs in terms of statistical precision and cost. The sensitivity of the crossover to bias due to carryover effects is examined. The feasibility of using the crossover data to test for the existence of carryover effects is investigated and found to be uneconomical. A numerical example is presented.
ISSN:0006-341X
1541-0420
DOI:10.2307/2530496