Reduced seizure control due to spoiled phenytoin capsules
Subtherapeutic phenytoin serum levels and loss of seizure control occurred in a 31‐year‐old man due to decreased bioavailability of oral drug. During storage at extreme temperatures, physical changes of the phenytion capsule resulted in altered dissolution characteristics so that only 50% dissolutio...
Gespeichert in:
| Veröffentlicht in: | Annals of neurology 1980-02, Vol.7 (2), p.191-193 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 193 |
|---|---|
| container_issue | 2 |
| container_start_page | 191 |
| container_title | Annals of neurology |
| container_volume | 7 |
| creator | Cloyd, James C. Gumnit, Robert J. Lesar, Timothy S. |
| description | Subtherapeutic phenytoin serum levels and loss of seizure control occurred in a 31‐year‐old man due to decreased bioavailability of oral drug. During storage at extreme temperatures, physical changes of the phenytion capsule resulted in altered dissolution characteristics so that only 50% dissolution occurred at 180 minutes compared with 95% in 120 minutes for control capsules. Similar changes were produced in fresh capsules within seven days at high temperature and humidity. The affected patient has metabolic responses to phenytoin that produce marked fluctuations in serum levels with changes in dose. Altered phenytoin serum concentrations may occur with minor dose changes in such patients despite good compliance. |
| doi_str_mv | 10.1002/ana.410070218 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75089915</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>75089915</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3748-c8359cbdc18b1edfd15ab52fd9a2e946ebb3fcaa1dded6c032d3fa8a5bd5d2be3</originalsourceid><addsrcrecordid>eNp9kM9LwzAYhoMoc06PHoWevHXmR9M0xzl0CnPqUDyGNPmK1a6pSYvOv97KxvDk6Qu8bx6-70HolOAxwZhe6FqPk_4lMCXZHhoSzkic0UTuoyFmaRJzwpJDdBTCG8ZYpgQP0ECwVArKh0guwXYGbBSg_O48RMbVrXdVZDuIWheFxpVVHzevUK9bV9aR0U3oKgjH6KDQVYCT7Ryh5-urp-lNPL-f3U4n89gwkWSxyRiXJreGZDkBW1jCdc5pYaWmIJMU8pwVRmtiLdjUYEYtK3SmeW65pTmwETrfcBvvPjoIrVqVwUBV6RpcF5TgOJOyv3qE4k3ReBeCh0I1vlxpv1YEq19Vqleldqr6_tkW3OUrsLv21k2fi03-2RtY_w9Tk8XkL3m7SRla-Nr91P5dpYIJrl4WM0UvyePyLnlQC_YDrIOFTQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75089915</pqid></control><display><type>article</type><title>Reduced seizure control due to spoiled phenytoin capsules</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Cloyd, James C. ; Gumnit, Robert J. ; Lesar, Timothy S.</creator><creatorcontrib>Cloyd, James C. ; Gumnit, Robert J. ; Lesar, Timothy S.</creatorcontrib><description>Subtherapeutic phenytoin serum levels and loss of seizure control occurred in a 31‐year‐old man due to decreased bioavailability of oral drug. During storage at extreme temperatures, physical changes of the phenytion capsule resulted in altered dissolution characteristics so that only 50% dissolution occurred at 180 minutes compared with 95% in 120 minutes for control capsules. Similar changes were produced in fresh capsules within seven days at high temperature and humidity. The affected patient has metabolic responses to phenytoin that produce marked fluctuations in serum levels with changes in dose. Altered phenytoin serum concentrations may occur with minor dose changes in such patients despite good compliance.</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.410070218</identifier><identifier>PMID: 7369725</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Biological Availability ; Drug Stability ; Drug Storage ; Epilepsy - blood ; Epilepsy - drug therapy ; Humans ; Humidity ; Male ; Phenytoin - blood ; Phenytoin - standards ; Temperature</subject><ispartof>Annals of neurology, 1980-02, Vol.7 (2), p.191-193</ispartof><rights>Copyright © 1980 American Neurological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3748-c8359cbdc18b1edfd15ab52fd9a2e946ebb3fcaa1dded6c032d3fa8a5bd5d2be3</citedby><cites>FETCH-LOGICAL-c3748-c8359cbdc18b1edfd15ab52fd9a2e946ebb3fcaa1dded6c032d3fa8a5bd5d2be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.410070218$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.410070218$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7369725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cloyd, James C.</creatorcontrib><creatorcontrib>Gumnit, Robert J.</creatorcontrib><creatorcontrib>Lesar, Timothy S.</creatorcontrib><title>Reduced seizure control due to spoiled phenytoin capsules</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>Subtherapeutic phenytoin serum levels and loss of seizure control occurred in a 31‐year‐old man due to decreased bioavailability of oral drug. During storage at extreme temperatures, physical changes of the phenytion capsule resulted in altered dissolution characteristics so that only 50% dissolution occurred at 180 minutes compared with 95% in 120 minutes for control capsules. Similar changes were produced in fresh capsules within seven days at high temperature and humidity. The affected patient has metabolic responses to phenytoin that produce marked fluctuations in serum levels with changes in dose. Altered phenytoin serum concentrations may occur with minor dose changes in such patients despite good compliance.</description><subject>Adult</subject><subject>Biological Availability</subject><subject>Drug Stability</subject><subject>Drug Storage</subject><subject>Epilepsy - blood</subject><subject>Epilepsy - drug therapy</subject><subject>Humans</subject><subject>Humidity</subject><subject>Male</subject><subject>Phenytoin - blood</subject><subject>Phenytoin - standards</subject><subject>Temperature</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9LwzAYhoMoc06PHoWevHXmR9M0xzl0CnPqUDyGNPmK1a6pSYvOv97KxvDk6Qu8bx6-70HolOAxwZhe6FqPk_4lMCXZHhoSzkic0UTuoyFmaRJzwpJDdBTCG8ZYpgQP0ECwVArKh0guwXYGbBSg_O48RMbVrXdVZDuIWheFxpVVHzevUK9bV9aR0U3oKgjH6KDQVYCT7Ryh5-urp-lNPL-f3U4n89gwkWSxyRiXJreGZDkBW1jCdc5pYaWmIJMU8pwVRmtiLdjUYEYtK3SmeW65pTmwETrfcBvvPjoIrVqVwUBV6RpcF5TgOJOyv3qE4k3ReBeCh0I1vlxpv1YEq19Vqleldqr6_tkW3OUrsLv21k2fi03-2RtY_w9Tk8XkL3m7SRla-Nr91P5dpYIJrl4WM0UvyePyLnlQC_YDrIOFTQ</recordid><startdate>198002</startdate><enddate>198002</enddate><creator>Cloyd, James C.</creator><creator>Gumnit, Robert J.</creator><creator>Lesar, Timothy S.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198002</creationdate><title>Reduced seizure control due to spoiled phenytoin capsules</title><author>Cloyd, James C. ; Gumnit, Robert J. ; Lesar, Timothy S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3748-c8359cbdc18b1edfd15ab52fd9a2e946ebb3fcaa1dded6c032d3fa8a5bd5d2be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Adult</topic><topic>Biological Availability</topic><topic>Drug Stability</topic><topic>Drug Storage</topic><topic>Epilepsy - blood</topic><topic>Epilepsy - drug therapy</topic><topic>Humans</topic><topic>Humidity</topic><topic>Male</topic><topic>Phenytoin - blood</topic><topic>Phenytoin - standards</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cloyd, James C.</creatorcontrib><creatorcontrib>Gumnit, Robert J.</creatorcontrib><creatorcontrib>Lesar, Timothy S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cloyd, James C.</au><au>Gumnit, Robert J.</au><au>Lesar, Timothy S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced seizure control due to spoiled phenytoin capsules</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>1980-02</date><risdate>1980</risdate><volume>7</volume><issue>2</issue><spage>191</spage><epage>193</epage><pages>191-193</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><abstract>Subtherapeutic phenytoin serum levels and loss of seizure control occurred in a 31‐year‐old man due to decreased bioavailability of oral drug. During storage at extreme temperatures, physical changes of the phenytion capsule resulted in altered dissolution characteristics so that only 50% dissolution occurred at 180 minutes compared with 95% in 120 minutes for control capsules. Similar changes were produced in fresh capsules within seven days at high temperature and humidity. The affected patient has metabolic responses to phenytoin that produce marked fluctuations in serum levels with changes in dose. Altered phenytoin serum concentrations may occur with minor dose changes in such patients despite good compliance.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>7369725</pmid><doi>10.1002/ana.410070218</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-5134 |
| ispartof | Annals of neurology, 1980-02, Vol.7 (2), p.191-193 |
| issn | 0364-5134 1531-8249 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75089915 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Biological Availability Drug Stability Drug Storage Epilepsy - blood Epilepsy - drug therapy Humans Humidity Male Phenytoin - blood Phenytoin - standards Temperature |
| title | Reduced seizure control due to spoiled phenytoin capsules |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T08%3A08%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reduced%20seizure%20control%20due%20to%20spoiled%20phenytoin%20capsules&rft.jtitle=Annals%20of%20neurology&rft.au=Cloyd,%20James%20C.&rft.date=1980-02&rft.volume=7&rft.issue=2&rft.spage=191&rft.epage=193&rft.pages=191-193&rft.issn=0364-5134&rft.eissn=1531-8249&rft_id=info:doi/10.1002/ana.410070218&rft_dat=%3Cproquest_cross%3E75089915%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75089915&rft_id=info:pmid/7369725&rfr_iscdi=true |