Effects of thymectomy on mammary tumor growth
The effect of thymectomy on prognosis following mammary tumor excision was evaluated in female C 3H MTV + mice, 5 to 6 months old, with spontaneous tumors 0.5 to 1 cm in diameter after random allocation to thymectomy or sham operation. Significant differences between these two groups were noted in a...
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| Veröffentlicht in: | The Journal of surgical research 1980-04, Vol.28 (4), p.348-355 |
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| container_title | The Journal of surgical research |
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| creator | Peer, Gary Papatestas, Angelos E. Tartter, Paul Bekesi, George Genkins, Gabriel Aufses, Arthur H. |
| description | The effect of thymectomy on prognosis following mammary tumor excision was evaluated in female C
3H MTV + mice, 5 to 6 months old, with spontaneous tumors 0.5 to 1 cm in diameter after random allocation to thymectomy or sham operation. Significant differences between these two groups were noted in absolute survival, disease-free survival, interval to tumor reappearance, and survival following tumor reappearance. Thymectomy prolonged survival both in tumor-free and tumor-bearing mice and delayed the reappearance of the tumors. The results indicate that thymectomy, when used as an adjuvant to surgical ablation of mammary tumors, has a therapeutic role. Both the previously reported protective effect of thymectomy against the risk of mammary neoplasia and the observed protective role following tumor occurrence could be attributed to its metabolic and immunoregulatory effects. |
| doi_str_mv | 10.1016/0022-4804(80)90095-5 |
| format | Article |
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3H MTV + mice, 5 to 6 months old, with spontaneous tumors 0.5 to 1 cm in diameter after random allocation to thymectomy or sham operation. Significant differences between these two groups were noted in absolute survival, disease-free survival, interval to tumor reappearance, and survival following tumor reappearance. Thymectomy prolonged survival both in tumor-free and tumor-bearing mice and delayed the reappearance of the tumors. The results indicate that thymectomy, when used as an adjuvant to surgical ablation of mammary tumors, has a therapeutic role. Both the previously reported protective effect of thymectomy against the risk of mammary neoplasia and the observed protective role following tumor occurrence could be attributed to its metabolic and immunoregulatory effects.</description><identifier>ISSN: 0022-4804</identifier><identifier>EISSN: 1095-8673</identifier><identifier>DOI: 10.1016/0022-4804(80)90095-5</identifier><identifier>PMID: 7366194</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Crosses, Genetic ; Female ; Mammary Neoplasms, Experimental - mortality ; Mammary Neoplasms, Experimental - pathology ; Mammary Neoplasms, Experimental - therapy ; Mice ; Mice, Inbred C3H ; Neoplasm Recurrence, Local ; Thymectomy</subject><ispartof>The Journal of surgical research, 1980-04, Vol.28 (4), p.348-355</ispartof><rights>1980</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-d8fae858a9593f92425098ddc93eb7516a64c40c583b67f738612f2c649ba8e23</citedby><cites>FETCH-LOGICAL-c357t-d8fae858a9593f92425098ddc93eb7516a64c40c583b67f738612f2c649ba8e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0022480480900955$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7366194$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peer, Gary</creatorcontrib><creatorcontrib>Papatestas, Angelos E.</creatorcontrib><creatorcontrib>Tartter, Paul</creatorcontrib><creatorcontrib>Bekesi, George</creatorcontrib><creatorcontrib>Genkins, Gabriel</creatorcontrib><creatorcontrib>Aufses, Arthur H.</creatorcontrib><title>Effects of thymectomy on mammary tumor growth</title><title>The Journal of surgical research</title><addtitle>J Surg Res</addtitle><description>The effect of thymectomy on prognosis following mammary tumor excision was evaluated in female C
3H MTV + mice, 5 to 6 months old, with spontaneous tumors 0.5 to 1 cm in diameter after random allocation to thymectomy or sham operation. Significant differences between these two groups were noted in absolute survival, disease-free survival, interval to tumor reappearance, and survival following tumor reappearance. Thymectomy prolonged survival both in tumor-free and tumor-bearing mice and delayed the reappearance of the tumors. The results indicate that thymectomy, when used as an adjuvant to surgical ablation of mammary tumors, has a therapeutic role. Both the previously reported protective effect of thymectomy against the risk of mammary neoplasia and the observed protective role following tumor occurrence could be attributed to its metabolic and immunoregulatory effects.</description><subject>Animals</subject><subject>Crosses, Genetic</subject><subject>Female</subject><subject>Mammary Neoplasms, Experimental - mortality</subject><subject>Mammary Neoplasms, Experimental - pathology</subject><subject>Mammary Neoplasms, Experimental - therapy</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Neoplasm Recurrence, Local</subject><subject>Thymectomy</subject><issn>0022-4804</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKAzEUhoMotVbfQGFWoovR3C8boZR6gYIbXYdMJrEjTVOTGaVv74wtXbo65_D_5_YBcIngHYKI30OIcUklpDcS3ioIFSvZERijIZFckGMwPlhOwVnOn7CvlSAjMBKEc6ToGJRz751tcxF90S63oc9j2BZxXQQTgknbou1CTMVHij_t8hyceLPK7mIfJ-D9cf42ey4Xr08vs-mitISJtqylN04yaRRTxCtMMYNK1rVVxFWCIW44tRRaJknFhRdEcoQ9tpyqykiHyQRc7-ZuUvzqXG51aLJ1q5VZu9hlLRgUjMnBSHdGm2LOyXm9Sc1wtkZQD5T0gEAPCLSE-o-SZn3b1X5-VwVXH5r2WHr9Yae7_snvxiWdbePW1tVN6gnpOjb_L_gFxWB0yg</recordid><startdate>198004</startdate><enddate>198004</enddate><creator>Peer, Gary</creator><creator>Papatestas, Angelos E.</creator><creator>Tartter, Paul</creator><creator>Bekesi, George</creator><creator>Genkins, Gabriel</creator><creator>Aufses, Arthur H.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198004</creationdate><title>Effects of thymectomy on mammary tumor growth</title><author>Peer, Gary ; Papatestas, Angelos E. ; Tartter, Paul ; Bekesi, George ; Genkins, Gabriel ; Aufses, Arthur H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-d8fae858a9593f92425098ddc93eb7516a64c40c583b67f738612f2c649ba8e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Crosses, Genetic</topic><topic>Female</topic><topic>Mammary Neoplasms, Experimental - mortality</topic><topic>Mammary Neoplasms, Experimental - pathology</topic><topic>Mammary Neoplasms, Experimental - therapy</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Neoplasm Recurrence, Local</topic><topic>Thymectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peer, Gary</creatorcontrib><creatorcontrib>Papatestas, Angelos E.</creatorcontrib><creatorcontrib>Tartter, Paul</creatorcontrib><creatorcontrib>Bekesi, George</creatorcontrib><creatorcontrib>Genkins, Gabriel</creatorcontrib><creatorcontrib>Aufses, Arthur H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peer, Gary</au><au>Papatestas, Angelos E.</au><au>Tartter, Paul</au><au>Bekesi, George</au><au>Genkins, Gabriel</au><au>Aufses, Arthur H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of thymectomy on mammary tumor growth</atitle><jtitle>The Journal of surgical research</jtitle><addtitle>J Surg Res</addtitle><date>1980-04</date><risdate>1980</risdate><volume>28</volume><issue>4</issue><spage>348</spage><epage>355</epage><pages>348-355</pages><issn>0022-4804</issn><eissn>1095-8673</eissn><abstract>The effect of thymectomy on prognosis following mammary tumor excision was evaluated in female C
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| ispartof | The Journal of surgical research, 1980-04, Vol.28 (4), p.348-355 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Crosses, Genetic Female Mammary Neoplasms, Experimental - mortality Mammary Neoplasms, Experimental - pathology Mammary Neoplasms, Experimental - therapy Mice Mice, Inbred C3H Neoplasm Recurrence, Local Thymectomy |
| title | Effects of thymectomy on mammary tumor growth |
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