Quantitative structure-activity correlations of rifamycins as inhibitors of viral RNA-directed DNA polymerase and mammalian .alpha. and .beta. DNA polymerases

Twenty-two 3-substituted rifamycins were tested for inhibition of mammalian alpha and beta DNA polymerase and viral RNA-dependent DNA polymerase ("reverse transcriptase"). Quantitative structure--activity relationships (QSAR) were formulated for the three systems. Inhibition is linearly de...

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Veröffentlicht in:	Journal of medicinal chemistry 1980-03, Vol.23 (3), p.256-261
Hauptverfasser:	Wu, Roy S, DeFilippes, Mary K. Wolpert, Quinn, Frank R
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals In Vitro Techniques Mathematics Mice Nucleic Acid Synthesis Inhibitors Reverse Transcriptase Inhibitors Rifamycins - pharmacology Sarcoma Virus, Woolly Monkey - drug effects Sarcoma Virus, Woolly Monkey - enzymology Solubility Structure-Activity Relationship Viruses - drug effects Viruses - enzymology
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