Serum Antibody and Opsonic Responses to Vaccination with Pneumococcal Capsular Polysaccharide in Normal and Splenectomized Children
Serum pneumococcal antibody and opsonic activity were measured in normal and splenectomized children before and after vaccination with capsular polysaccharides of Streptococcus pneumoniae. Splenectomized children showed a lower mean antibody response to four capsular polysaccharide types after vacci...
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| Veröffentlicht in: | The Journal of infectious diseases 1980-03, Vol.141 (3), p.404-412 |
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| container_title | The Journal of infectious diseases |
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| creator | Giebink, G. Scott Foker, John E. Kim, Youngki Schiffman, Gerald |
| description | Serum pneumococcal antibody and opsonic activity were measured in normal and splenectomized children before and after vaccination with capsular polysaccharides of Streptococcus pneumoniae. Splenectomized children showed a lower mean antibody response to four capsular polysaccharide types after vaccination but had higher antibody levels than normal children before vaccination for 10 of the 12 antigen types. Two splenectomized children showed high serum antibody levels before vaccination but low autologous pneumococcal opsonic activity, measured with a phagocytic test that employednormal human leukocytes. Thirteen (42%) of 31 splenectomized patients and three (25%) of 12 normal subjects with a twofold pneumococcal antibody increase after vaccination failed to show an autologous opsonic response. Alternative-pathway opsonic activity was moderately reduced in five splenectomized patients; however, immunochemical measurements of Clq, C3, properdin, and factor B were normal in all patient sera. These observations suggest that vaccination with pneumococcal polysaccharides may not enhance serum opsonic activity against vaccine pneumococcal types in some splenectomized, as well as unsplenectomized, children. |
| doi_str_mv | 10.1093/infdis/141.3.404 |
| format | Article |
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Scott ; Foker, John E. ; Kim, Youngki ; Schiffman, Gerald</creator><creatorcontrib>Giebink, G. Scott ; Foker, John E. ; Kim, Youngki ; Schiffman, Gerald</creatorcontrib><description>Serum pneumococcal antibody and opsonic activity were measured in normal and splenectomized children before and after vaccination with capsular polysaccharides of Streptococcus pneumoniae. Splenectomized children showed a lower mean antibody response to four capsular polysaccharide types after vaccination but had higher antibody levels than normal children before vaccination for 10 of the 12 antigen types. Two splenectomized children showed high serum antibody levels before vaccination but low autologous pneumococcal opsonic activity, measured with a phagocytic test that employednormal human leukocytes. Thirteen (42%) of 31 splenectomized patients and three (25%) of 12 normal subjects with a twofold pneumococcal antibody increase after vaccination failed to show an autologous opsonic response. Alternative-pathway opsonic activity was moderately reduced in five splenectomized patients; however, immunochemical measurements of Clq, C3, properdin, and factor B were normal in all patient sera. These observations suggest that vaccination with pneumococcal polysaccharides may not enhance serum opsonic activity against vaccine pneumococcal types in some splenectomized, as well as unsplenectomized, children.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/141.3.404</identifier><identifier>PMID: 6988526</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Adolescent ; Adult ; Antibodies ; Antibodies, Bacterial - biosynthesis ; Antibody formation ; Antigens ; Bacterial Vaccines - immunology ; Child ; Child health services ; Child, Preschool ; Children ; Complement Pathway, Classical ; Humans ; Medical Miscellany ; Opsonin Proteins - immunology ; Phagocytosis ; Polysaccharides ; Polysaccharides, Bacterial - immunology ; Salmonella typhimurium - immunology ; Splenectomy ; Streptococcus pneumoniae ; Streptococcus pneumoniae - immunology ; Vaccination</subject><ispartof>The Journal of infectious diseases, 1980-03, Vol.141 (3), p.404-412</ispartof><rights>Copyright 1980 The University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-5950693e106e1afe3747f8d2af35444243683ba12450f30ccb3045dd545a781c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30081715$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30081715$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6988526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giebink, G. Scott</creatorcontrib><creatorcontrib>Foker, John E.</creatorcontrib><creatorcontrib>Kim, Youngki</creatorcontrib><creatorcontrib>Schiffman, Gerald</creatorcontrib><title>Serum Antibody and Opsonic Responses to Vaccination with Pneumococcal Capsular Polysaccharide in Normal and Splenectomized Children</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Serum pneumococcal antibody and opsonic activity were measured in normal and splenectomized children before and after vaccination with capsular polysaccharides of Streptococcus pneumoniae. Splenectomized children showed a lower mean antibody response to four capsular polysaccharide types after vaccination but had higher antibody levels than normal children before vaccination for 10 of the 12 antigen types. Two splenectomized children showed high serum antibody levels before vaccination but low autologous pneumococcal opsonic activity, measured with a phagocytic test that employednormal human leukocytes. Thirteen (42%) of 31 splenectomized patients and three (25%) of 12 normal subjects with a twofold pneumococcal antibody increase after vaccination failed to show an autologous opsonic response. Alternative-pathway opsonic activity was moderately reduced in five splenectomized patients; however, immunochemical measurements of Clq, C3, properdin, and factor B were normal in all patient sera. These observations suggest that vaccination with pneumococcal polysaccharides may not enhance serum opsonic activity against vaccine pneumococcal types in some splenectomized, as well as unsplenectomized, children.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - biosynthesis</subject><subject>Antibody formation</subject><subject>Antigens</subject><subject>Bacterial Vaccines - immunology</subject><subject>Child</subject><subject>Child health services</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Complement Pathway, Classical</subject><subject>Humans</subject><subject>Medical Miscellany</subject><subject>Opsonin Proteins - immunology</subject><subject>Phagocytosis</subject><subject>Polysaccharides</subject><subject>Polysaccharides, Bacterial - immunology</subject><subject>Salmonella typhimurium - immunology</subject><subject>Splenectomy</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - immunology</subject><subject>Vaccination</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU2P0zAQhi0EWkrhzgXJJ27pjmM7To6rCijSil1t-RIXy7UnqpfEztqJoFz542TVqpzm8LzzSvMMIa8ZrBg0_NKH1vl8yQRb8ZUA8YQsmOSqqCrGn5IFQFkWrG6a5-RFzvcAIHilLshF1dS1LKsF-bvFNPX0Kox-F92BmuDozZBj8JbeYR5iyJjpGOlXY60PZvQx0F9-3NPbgFMfbbTWdHRthjx1JtHb2B3yHN2b5B1SH-inmPo58Vi8HToMaMfY-z_o6HrvO5cwvCTPWtNlfHWaS_Ll_bvP601xffPh4_rqurBcirGQjYSq4cigQmZa5EqotnalaWcsRDmfVvOdYaWQ0HKwdsdBSOekkEbVzPIleXvsHVJ8mDCPuvfZYteZgHHKWklQDEqYg3AM2hRzTtjqIfnepINmoB-966N3PXvXXM_e55U3p-5p16M7L5xE_-f3eYzpjDlAzdT8siUpjtznEX-fuUk_daW4knrz_Ye-WyvYfttwrfg_d_GaAQ</recordid><startdate>198003</startdate><enddate>198003</enddate><creator>Giebink, G. Scott</creator><creator>Foker, John E.</creator><creator>Kim, Youngki</creator><creator>Schiffman, Gerald</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198003</creationdate><title>Serum Antibody and Opsonic Responses to Vaccination with Pneumococcal Capsular Polysaccharide in Normal and Splenectomized Children</title><author>Giebink, G. Scott ; Foker, John E. ; Kim, Youngki ; Schiffman, Gerald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-5950693e106e1afe3747f8d2af35444243683ba12450f30ccb3045dd545a781c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial - biosynthesis</topic><topic>Antibody formation</topic><topic>Antigens</topic><topic>Bacterial Vaccines - immunology</topic><topic>Child</topic><topic>Child health services</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Complement Pathway, Classical</topic><topic>Humans</topic><topic>Medical Miscellany</topic><topic>Opsonin Proteins - immunology</topic><topic>Phagocytosis</topic><topic>Polysaccharides</topic><topic>Polysaccharides, Bacterial - immunology</topic><topic>Salmonella typhimurium - immunology</topic><topic>Splenectomy</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pneumoniae - immunology</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giebink, G. Scott</creatorcontrib><creatorcontrib>Foker, John E.</creatorcontrib><creatorcontrib>Kim, Youngki</creatorcontrib><creatorcontrib>Schiffman, Gerald</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giebink, G. Scott</au><au>Foker, John E.</au><au>Kim, Youngki</au><au>Schiffman, Gerald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Antibody and Opsonic Responses to Vaccination with Pneumococcal Capsular Polysaccharide in Normal and Splenectomized Children</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1980-03</date><risdate>1980</risdate><volume>141</volume><issue>3</issue><spage>404</spage><epage>412</epage><pages>404-412</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Serum pneumococcal antibody and opsonic activity were measured in normal and splenectomized children before and after vaccination with capsular polysaccharides of Streptococcus pneumoniae. Splenectomized children showed a lower mean antibody response to four capsular polysaccharide types after vaccination but had higher antibody levels than normal children before vaccination for 10 of the 12 antigen types. Two splenectomized children showed high serum antibody levels before vaccination but low autologous pneumococcal opsonic activity, measured with a phagocytic test that employednormal human leukocytes. Thirteen (42%) of 31 splenectomized patients and three (25%) of 12 normal subjects with a twofold pneumococcal antibody increase after vaccination failed to show an autologous opsonic response. Alternative-pathway opsonic activity was moderately reduced in five splenectomized patients; however, immunochemical measurements of Clq, C3, properdin, and factor B were normal in all patient sera. These observations suggest that vaccination with pneumococcal polysaccharides may not enhance serum opsonic activity against vaccine pneumococcal types in some splenectomized, as well as unsplenectomized, children.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>6988526</pmid><doi>10.1093/infdis/141.3.404</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | The Journal of infectious diseases, 1980-03, Vol.141 (3), p.404-412 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | MEDLINE; Jstor Complete Legacy |
| subjects | Adolescent Adult Antibodies Antibodies, Bacterial - biosynthesis Antibody formation Antigens Bacterial Vaccines - immunology Child Child health services Child, Preschool Children Complement Pathway, Classical Humans Medical Miscellany Opsonin Proteins - immunology Phagocytosis Polysaccharides Polysaccharides, Bacterial - immunology Salmonella typhimurium - immunology Splenectomy Streptococcus pneumoniae Streptococcus pneumoniae - immunology Vaccination |
| title | Serum Antibody and Opsonic Responses to Vaccination with Pneumococcal Capsular Polysaccharide in Normal and Splenectomized Children |
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