The Gonadotropin Response of Men with Varicoceles to Gonadotropin-Releasing Hormone
The serum gonadotropin and testosterone responses to 100μg of intravenously administered gonadotropin-releasing hormone (GnRH) were studied, over 180minutes, in four groups of men: severely oligospermic men with varicoceles and sperm densities 10 million/ml, severely oligospermic men without varicoc...
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| Veröffentlicht in: | Fertility and sterility 1980-04, Vol.33 (4), p.427-432 |
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| creator | Hudson, Robert W. Mckay, David E. |
| description | The serum gonadotropin and testosterone responses to 100μg of intravenously administered gonadotropin-releasing hormone (GnRH) were studied, over 180minutes, in four groups of men: severely oligospermic men with varicoceles and sperm densities 10 million/ml, severely oligospermic men without varicoceles, and men of normal fertility. Each group had similar preinjection gonadotropin and testosterone levels. Following the injection of GnRH, the severely oligospermic men with varicoceles had excessive increases in luteinizing hormone and follicle-stimulating hormone levels and a slower return to preinjection values as compared with the other three groups. The responses of the other groups were not different from each other. There was not a consistent increase in testosterone levels in any group during the period of the study. These results suggest that severely oligospermic men with varicoceles have a pantesticular defect in testosterone synthesis and spermatogenesis which can be demonstrated by their response to GnRH. |
| doi_str_mv | 10.1016/S0015-0282(16)44662-5 |
| format | Article |
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Each group had similar preinjection gonadotropin and testosterone levels. Following the injection of GnRH, the severely oligospermic men with varicoceles had excessive increases in luteinizing hormone and follicle-stimulating hormone levels and a slower return to preinjection values as compared with the other three groups. The responses of the other groups were not different from each other. There was not a consistent increase in testosterone levels in any group during the period of the study. These results suggest that severely oligospermic men with varicoceles have a pantesticular defect in testosterone synthesis and spermatogenesis which can be demonstrated by their response to GnRH.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)44662-5</identifier><identifier>PMID: 6767632</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Dose-Response Relationship, Drug ; Follicle Stimulating Hormone - blood ; Gonadotropins, Pituitary - blood ; Humans ; Injections, Intravenous ; Injections, Subcutaneous ; Luteinizing Hormone - blood ; Male ; Oligospermia - diagnosis ; Pituitary Hormone-Releasing Hormones - administration & dosage ; Sperm Count ; Testosterone - blood ; Varicocele - diagnosis</subject><ispartof>Fertility and sterility, 1980-04, Vol.33 (4), p.427-432</ispartof><rights>1980 American Society for Reproductive Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-d865cf9f27465e549886f367728b846c962f93fe410401aaef9ea1816ebd5aa53</citedby><cites>FETCH-LOGICAL-c407t-d865cf9f27465e549886f367728b846c962f93fe410401aaef9ea1816ebd5aa53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-0282(16)44662-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6767632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hudson, Robert W.</creatorcontrib><creatorcontrib>Mckay, David E.</creatorcontrib><title>The Gonadotropin Response of Men with Varicoceles to Gonadotropin-Releasing Hormone</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>The serum gonadotropin and testosterone responses to 100μg of intravenously administered gonadotropin-releasing hormone (GnRH) were studied, over 180minutes, in four groups of men: severely oligospermic men with varicoceles and sperm densities <10 million/ml, men with varicoceles and sperm densities >10 million/ml, severely oligospermic men without varicoceles, and men of normal fertility. Each group had similar preinjection gonadotropin and testosterone levels. Following the injection of GnRH, the severely oligospermic men with varicoceles had excessive increases in luteinizing hormone and follicle-stimulating hormone levels and a slower return to preinjection values as compared with the other three groups. The responses of the other groups were not different from each other. There was not a consistent increase in testosterone levels in any group during the period of the study. These results suggest that severely oligospermic men with varicoceles have a pantesticular defect in testosterone synthesis and spermatogenesis which can be demonstrated by their response to GnRH.</description><subject>Adult</subject><subject>Dose-Response Relationship, Drug</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gonadotropins, Pituitary - blood</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Injections, Subcutaneous</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Oligospermia - diagnosis</subject><subject>Pituitary Hormone-Releasing Hormones - administration & dosage</subject><subject>Sperm Count</subject><subject>Testosterone - blood</subject><subject>Varicocele - diagnosis</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9LAzEQxYMotVY_QmFPoofVZDfJZk8iRVuhIrTVa0izExvpJjXZKn57t38oeJIchuS9mZf5IdQn-IZgwm-nGBOW4kxkV4RfU8p5lrIj1CWM8ZRxlh-j7sFyis5i_MAYc1JkHdThRXvyrIumswUkQ-9U5ZvgV9YlE4gr7yIk3iTP4JJv2yySNxWs9hqWEJPG_2lIJ-2rita9JyMfau_gHJ0YtYxwsa899Pr4MBuM0vHL8GlwP041xUWTVoIzbUqTFZQzYLQUgpucF0Um5oJyXfLMlLkBSjDFRCkwJSgiCId5xZRieQ9d7uaugv9cQ2xkbWP7x6Vy4NdRFgzzQgjSGtnOqIOPMYCRq2BrFX4kwXIDU25hyg0p2d62MOUmoL8PWM9rqA5de3qtfrfTod3yy0KQUVtwGiobQDey8vafhF80aYPZ</recordid><startdate>198004</startdate><enddate>198004</enddate><creator>Hudson, Robert W.</creator><creator>Mckay, David E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198004</creationdate><title>The Gonadotropin Response of Men with Varicoceles to Gonadotropin-Releasing Hormone</title><author>Hudson, Robert W. ; Mckay, David E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-d865cf9f27465e549886f367728b846c962f93fe410401aaef9ea1816ebd5aa53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Adult</topic><topic>Dose-Response Relationship, Drug</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gonadotropins, Pituitary - blood</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Injections, Subcutaneous</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Oligospermia - diagnosis</topic><topic>Pituitary Hormone-Releasing Hormones - administration & dosage</topic><topic>Sperm Count</topic><topic>Testosterone - blood</topic><topic>Varicocele - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hudson, Robert W.</creatorcontrib><creatorcontrib>Mckay, David E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hudson, Robert W.</au><au>Mckay, David E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Gonadotropin Response of Men with Varicoceles to Gonadotropin-Releasing Hormone</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1980-04</date><risdate>1980</risdate><volume>33</volume><issue>4</issue><spage>427</spage><epage>432</epage><pages>427-432</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><abstract>The serum gonadotropin and testosterone responses to 100μg of intravenously administered gonadotropin-releasing hormone (GnRH) were studied, over 180minutes, in four groups of men: severely oligospermic men with varicoceles and sperm densities <10 million/ml, men with varicoceles and sperm densities >10 million/ml, severely oligospermic men without varicoceles, and men of normal fertility. Each group had similar preinjection gonadotropin and testosterone levels. Following the injection of GnRH, the severely oligospermic men with varicoceles had excessive increases in luteinizing hormone and follicle-stimulating hormone levels and a slower return to preinjection values as compared with the other three groups. The responses of the other groups were not different from each other. There was not a consistent increase in testosterone levels in any group during the period of the study. These results suggest that severely oligospermic men with varicoceles have a pantesticular defect in testosterone synthesis and spermatogenesis which can be demonstrated by their response to GnRH.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6767632</pmid><doi>10.1016/S0015-0282(16)44662-5</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Fertility and sterility, 1980-04, Vol.33 (4), p.427-432 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present); Alma/SFX Local Collection |
| subjects | Adult Dose-Response Relationship, Drug Follicle Stimulating Hormone - blood Gonadotropins, Pituitary - blood Humans Injections, Intravenous Injections, Subcutaneous Luteinizing Hormone - blood Male Oligospermia - diagnosis Pituitary Hormone-Releasing Hormones - administration & dosage Sperm Count Testosterone - blood Varicocele - diagnosis |
| title | The Gonadotropin Response of Men with Varicoceles to Gonadotropin-Releasing Hormone |
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