Evaluation of Sunscreen Protection by Measurement of Epidermal DNA Synthesis
Different sunscreens were tested to determine their protection of epidermis from ultraviolet light effects. Ultraviolet light-induced changes in hairless mouse epidermal DNA synthesis were used for measurement of sunscreen protection. Visual assessment of erythema and edema was also performed. This...
Gespeichert in:
| Veröffentlicht in: | Journal of investigative dermatology 1980-03, Vol.74 (3), p.181-182 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 182 |
|---|---|
| container_issue | 3 |
| container_start_page | 181 |
| container_title | Journal of investigative dermatology |
| container_volume | 74 |
| creator | Lowe, Nicholas J. Breeding, James |
| description | Different sunscreens were tested to determine their protection of epidermis from ultraviolet light effects.
Ultraviolet light-induced changes in hairless mouse epidermal DNA synthesis were used for measurement of sunscreen protection. Visual assessment of erythema and edema was also performed.
This initial study has evaluated sunscreens containing para-aminobenzoic acid (PABA) as the principal sunscreen chemical.
These experiments were conducted using fluorescent sunlamp tubes and hydroxylapatite extraction of epidermal DNA. The ultraviolet light exposure was measured using a recording radiometer. The results showed that the sunscreens tested were able to partially prevent ultraviolet light induced changes in epidermal DNA synthesis.
It may be possible to use this assay as one of the initial evaluations of potential ultraviolet light protectants. |
| doi_str_mv | 10.1111/1523-1747.ep12535093 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75041489</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022202X15457410</els_id><sourcerecordid>75041489</sourcerecordid><originalsourceid>FETCH-LOGICAL-c425t-42dff1b8d570da4b2b6e8b5f56220d759fe706187c36ad59fffd2f4996988f793</originalsourceid><addsrcrecordid>eNp9kNtKAzEQhoMotVbfQGGvvNuaZJPs7o1Qaj1APUAVvAvZzQQjezLZLfTt3bWlvXNgGGb-f4bhQ-iS4Cnp44ZwGoUkZvEUGkJ5xHEaHaHxfnyMxhhTGlJMP0_RmfffGBPBeDJCI5EK3ucYLRdrVXSqtXUV1CZYdZXPHUAVvLm6hfxvnm2CZ1C-c1BC1Q62RWM1uFIVwd3LLFhtqvYLvPXn6MSowsPFrk7Qx_3iff4YLl8fnuazZZgzytuQUW0MyRLNY6wVy2gmIMm44YJSrGOeGoixIEmcR0LpvjVGU8PSVKRJYuI0mqDr7d3G1T8d-FaW1udQFKqCuvMy5pgRlgxGtjXmrvbegZGNs6VyG0mwHCDKgZYcaMkDxH7tane_y0rQ-6UdtYNeqbanste5IALzpNdvtzr0ENYWnPS5hSoHbV3PVOra_v_AL5gbixE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75041489</pqid></control><display><type>article</type><title>Evaluation of Sunscreen Protection by Measurement of Epidermal DNA Synthesis</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Lowe, Nicholas J. ; Breeding, James</creator><creatorcontrib>Lowe, Nicholas J. ; Breeding, James</creatorcontrib><description>Different sunscreens were tested to determine their protection of epidermis from ultraviolet light effects.
Ultraviolet light-induced changes in hairless mouse epidermal DNA synthesis were used for measurement of sunscreen protection. Visual assessment of erythema and edema was also performed.
This initial study has evaluated sunscreens containing para-aminobenzoic acid (PABA) as the principal sunscreen chemical.
These experiments were conducted using fluorescent sunlamp tubes and hydroxylapatite extraction of epidermal DNA. The ultraviolet light exposure was measured using a recording radiometer. The results showed that the sunscreens tested were able to partially prevent ultraviolet light induced changes in epidermal DNA synthesis.
It may be possible to use this assay as one of the initial evaluations of potential ultraviolet light protectants.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1111/1523-1747.ep12535093</identifier><identifier>PMID: 6965696</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>4-Aminobenzoic Acid - pharmacology ; Animals ; DNA - biosynthesis ; Drug Evaluation, Preclinical ; Epidermis - drug effects ; Epidermis - metabolism ; Evaluation Studies as Topic ; Mice ; Mice, Nude ; Sunscreening Agents</subject><ispartof>Journal of investigative dermatology, 1980-03, Vol.74 (3), p.181-182</ispartof><rights>1980 The Society for Investigative Dermatology, Inc</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-42dff1b8d570da4b2b6e8b5f56220d759fe706187c36ad59fffd2f4996988f793</citedby><cites>FETCH-LOGICAL-c425t-42dff1b8d570da4b2b6e8b5f56220d759fe706187c36ad59fffd2f4996988f793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6965696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lowe, Nicholas J.</creatorcontrib><creatorcontrib>Breeding, James</creatorcontrib><title>Evaluation of Sunscreen Protection by Measurement of Epidermal DNA Synthesis</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>Different sunscreens were tested to determine their protection of epidermis from ultraviolet light effects.
Ultraviolet light-induced changes in hairless mouse epidermal DNA synthesis were used for measurement of sunscreen protection. Visual assessment of erythema and edema was also performed.
This initial study has evaluated sunscreens containing para-aminobenzoic acid (PABA) as the principal sunscreen chemical.
These experiments were conducted using fluorescent sunlamp tubes and hydroxylapatite extraction of epidermal DNA. The ultraviolet light exposure was measured using a recording radiometer. The results showed that the sunscreens tested were able to partially prevent ultraviolet light induced changes in epidermal DNA synthesis.
It may be possible to use this assay as one of the initial evaluations of potential ultraviolet light protectants.</description><subject>4-Aminobenzoic Acid - pharmacology</subject><subject>Animals</subject><subject>DNA - biosynthesis</subject><subject>Drug Evaluation, Preclinical</subject><subject>Epidermis - drug effects</subject><subject>Epidermis - metabolism</subject><subject>Evaluation Studies as Topic</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Sunscreening Agents</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kNtKAzEQhoMotVbfQGGvvNuaZJPs7o1Qaj1APUAVvAvZzQQjezLZLfTt3bWlvXNgGGb-f4bhQ-iS4Cnp44ZwGoUkZvEUGkJ5xHEaHaHxfnyMxhhTGlJMP0_RmfffGBPBeDJCI5EK3ucYLRdrVXSqtXUV1CZYdZXPHUAVvLm6hfxvnm2CZ1C-c1BC1Q62RWM1uFIVwd3LLFhtqvYLvPXn6MSowsPFrk7Qx_3iff4YLl8fnuazZZgzytuQUW0MyRLNY6wVy2gmIMm44YJSrGOeGoixIEmcR0LpvjVGU8PSVKRJYuI0mqDr7d3G1T8d-FaW1udQFKqCuvMy5pgRlgxGtjXmrvbegZGNs6VyG0mwHCDKgZYcaMkDxH7tane_y0rQ-6UdtYNeqbanste5IALzpNdvtzr0ENYWnPS5hSoHbV3PVOra_v_AL5gbixE</recordid><startdate>198003</startdate><enddate>198003</enddate><creator>Lowe, Nicholas J.</creator><creator>Breeding, James</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198003</creationdate><title>Evaluation of Sunscreen Protection by Measurement of Epidermal DNA Synthesis</title><author>Lowe, Nicholas J. ; Breeding, James</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-42dff1b8d570da4b2b6e8b5f56220d759fe706187c36ad59fffd2f4996988f793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>4-Aminobenzoic Acid - pharmacology</topic><topic>Animals</topic><topic>DNA - biosynthesis</topic><topic>Drug Evaluation, Preclinical</topic><topic>Epidermis - drug effects</topic><topic>Epidermis - metabolism</topic><topic>Evaluation Studies as Topic</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Sunscreening Agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lowe, Nicholas J.</creatorcontrib><creatorcontrib>Breeding, James</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lowe, Nicholas J.</au><au>Breeding, James</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Sunscreen Protection by Measurement of Epidermal DNA Synthesis</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>1980-03</date><risdate>1980</risdate><volume>74</volume><issue>3</issue><spage>181</spage><epage>182</epage><pages>181-182</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><abstract>Different sunscreens were tested to determine their protection of epidermis from ultraviolet light effects.
Ultraviolet light-induced changes in hairless mouse epidermal DNA synthesis were used for measurement of sunscreen protection. Visual assessment of erythema and edema was also performed.
This initial study has evaluated sunscreens containing para-aminobenzoic acid (PABA) as the principal sunscreen chemical.
These experiments were conducted using fluorescent sunlamp tubes and hydroxylapatite extraction of epidermal DNA. The ultraviolet light exposure was measured using a recording radiometer. The results showed that the sunscreens tested were able to partially prevent ultraviolet light induced changes in epidermal DNA synthesis.
It may be possible to use this assay as one of the initial evaluations of potential ultraviolet light protectants.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6965696</pmid><doi>10.1111/1523-1747.ep12535093</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-202X |
| ispartof | Journal of investigative dermatology, 1980-03, Vol.74 (3), p.181-182 |
| issn | 0022-202X 1523-1747 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75041489 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 4-Aminobenzoic Acid - pharmacology Animals DNA - biosynthesis Drug Evaluation, Preclinical Epidermis - drug effects Epidermis - metabolism Evaluation Studies as Topic Mice Mice, Nude Sunscreening Agents |
| title | Evaluation of Sunscreen Protection by Measurement of Epidermal DNA Synthesis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T12%3A56%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20Sunscreen%20Protection%20by%20Measurement%20of%20Epidermal%20DNA%20Synthesis&rft.jtitle=Journal%20of%20investigative%20dermatology&rft.au=Lowe,%20Nicholas%20J.&rft.date=1980-03&rft.volume=74&rft.issue=3&rft.spage=181&rft.epage=182&rft.pages=181-182&rft.issn=0022-202X&rft.eissn=1523-1747&rft_id=info:doi/10.1111/1523-1747.ep12535093&rft_dat=%3Cproquest_cross%3E75041489%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75041489&rft_id=info:pmid/6965696&rft_els_id=S0022202X15457410&rfr_iscdi=true |