Twin Studies and Substrate Differences in Platelet Monoamine Oxidase Activity

Monoamine oxidase activity was measured in blood platelets of 7 pairs of identical (MZ) twins and a similar number of age- and sex-matched control pairs. Mean intrapair difference in platelet MAO activity was significantly smaller (0.01 < p < 0.025) in MZ compared to controls. Kinetic studies...

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Veröffentlicht in:	Human heredity 1980, Vol.30 (2), p.65-70
Hauptverfasser:	Hussein, Laila, Sindarto, E., Goedde, H. Werner
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Factors Blood Platelets - enzymology Female Humans Male Monoamine Oxidase - blood Monoamine Oxidase - genetics Original Paper Original Papers Pregnancy Sex Factors Substrate Specificity Tryptamines Twins Twins, Monozygotic Tyramine
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container_title	Human heredity
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creator	Hussein, Laila Sindarto, E. Goedde, H. Werner
description	Monoamine oxidase activity was measured in blood platelets of 7 pairs of identical (MZ) twins and a similar number of age- and sex-matched control pairs. Mean intrapair difference in platelet MAO activity was significantly smaller (0.01 < p < 0.025) in MZ compared to controls. Kinetic studies of the enzyme revealed mean Km value of 1.0 × 10⁻⁵ mol/1 for tryptamine. Platelet MAO activity is higher in women than in men.
doi_str_mv	10.1159/000153104
format	Article
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subjects	Adolescent Adult Age Factors Blood Platelets - enzymology Female Humans Male Monoamine Oxidase - blood Monoamine Oxidase - genetics Original Paper Original Papers Pregnancy Sex Factors Substrate Specificity Tryptamines Twins Twins, Monozygotic Tyramine
title	Twin Studies and Substrate Differences in Platelet Monoamine Oxidase Activity
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