L-phenylalanine mustard (melphalan) uptake and cross-linking in the RPMI 6410 human lymphoblastoid cell line

L-Phenylalanine mustard (melphalan) induced a time- and concentration-dependent arrest of cycling RPMI 6410 cells in the G2 phase of the cell cycle as evidenced by flow cytofluorometry. A melphalan exposure of 1 microgram/ml for 1 hr caused a temporary G2 blockage which was overcome by 48 hr. Higher...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1980-04, Vol.40 (4), p.1169-1172
Hauptverfasser:	Brox, L W, Gowans, B, Belch, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - pharmacology Biological Transport, Active Cell Cycle - drug effects Cell Line Cross-Linking Reagents DNA - metabolism Humans Lymphocytes - drug effects Lymphocytes - metabolism Melphalan - antagonists & inhibitors Melphalan - metabolism Melphalan - pharmacology Protein Binding
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!