Control of thymidine incorporation in mucosal explants from patients with chronic ulcerative colitis

Chronic ulcerative colitis is considered a “premalignant” lesion in patients with chronic and total colonic disease. In organ culture, we have studied the mucosa from normal human colon, and from patients with ulcerative colitis. These tissues were maintained for up to 20 hr in organ culture, and a...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1980-03, Vol.78 (3), p.470-478
Hauptverfasser:	Alpers, D.H., Philpott, G., Grimme, N.L., Margolis, D.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Transformation, Neoplastic Colitis, Ulcerative - metabolism Colon - metabolism Colonic Neoplasms - metabolism Cyclic AMP - metabolism DNA - biosynthesis Humans Intestinal Mucosa - metabolism Organ Culture Techniques Papaverine - pharmacology Phosphodiesterase Inhibitors - pharmacology Precancerous Conditions - metabolism Theophylline - pharmacology Thymidine - metabolism Time Factors
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