Tocainide Conjugation in Humans: Novel Biotransformation Pathway for a Primary Amine

The metabolism of tocainide, an experimental antiarrhythmic drug, was studied in humans. Urinary excretion of unchanged drug was 28-55% in 24 hr after oral dosing. Urine hydrolysis with hydrochloric acid or β-glucuronidase increased tocainide recovery to 55-79%. Saccharo-1,4-lactone inhibited the β-...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1980-01, Vol.69 (1), p.47-49
Hauptverfasser:	Elvin, A.T., Keenaghan, J.B., Byrnes, E.W., Tenthorey, P.A., McMaster, P.D., Takman, B.H., Lalka, D., Manion, C.V., Baer, D.T., Wolshin, E.M., Meyer, M.B., Ronfeld, R.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anilides - metabolism Anilides - urine Anti-Arrhythmia Agents - metabolism Anti-Arrhythmia Agents - urine Antiarrhythmic agents-tocainide Antiarrhythmic agents—tocainide, human metabolism, conjugation Biotransformation Carbon Dioxide - metabolism conjugation Glucuronates - metabolism Glucuronidase - metabolism human metabolism Humans Hydrolysis Metabolism-tocainide in humans Metabolism—tocainide in humans, conjugation Tocainide-human metabolism Tocainide—human metabolism, conjugation
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