Ontogenesis and independent genetic control of the rat adenylate kinase isozymes (EC 2.7.4.3.)
The level of activity of cytoplasmic isozyme II of adenylate kinase (EC 2.7.4.3) appears to be genetically controlled in the rat ( Rattus norvegicus). Adult animals of the Okamoto inbred strain exhibit a ninefold higher erythrocytic activity than the rats of the dilute agouti inbred strain. This dif...
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| Veröffentlicht in: | Archives of biochemistry and biophysics 1980, Vol.199 (1), p.76-83 |
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| container_title | Archives of biochemistry and biophysics |
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| creator | Carleer, J. Ansay, M. |
| description | The level of activity of cytoplasmic isozyme II of adenylate kinase (EC 2.7.4.3) appears to be genetically controlled in the rat (
Rattus norvegicus). Adult animals of the Okamoto inbred strain exhibit a ninefold higher erythrocytic activity than the rats of the dilute agouti inbred strain. This difference seems to be due to two codominant autosomal alleles at a same locus. The study of the ontogeny of that enzyme in muscle in the two strains shows that the wellknown postnatal activity increase of that isozyme is reduced in the low activity (dilute agouti) strain. However, the mitochondrial isozyme III activity is not similarly regulated as no difference between the two strains has been observed. |
| doi_str_mv | 10.1016/0003-9861(80)90258-1 |
| format | Article |
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Rattus norvegicus). Adult animals of the Okamoto inbred strain exhibit a ninefold higher erythrocytic activity than the rats of the dilute agouti inbred strain. This difference seems to be due to two codominant autosomal alleles at a same locus. The study of the ontogeny of that enzyme in muscle in the two strains shows that the wellknown postnatal activity increase of that isozyme is reduced in the low activity (dilute agouti) strain. However, the mitochondrial isozyme III activity is not similarly regulated as no difference between the two strains has been observed.</description><identifier>ISSN: 0003-9861</identifier><identifier>EISSN: 1096-0384</identifier><identifier>DOI: 10.1016/0003-9861(80)90258-1</identifier><identifier>PMID: 6243910</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adenylate Kinase - genetics ; Adenylate Kinase - metabolism ; Animals ; Crosses, Genetic ; Isoenzymes - genetics ; Isoenzymes - metabolism ; Liver - enzymology ; Muscles - enzymology ; Phosphotransferases - metabolism ; Rats ; Species Specificity ; Tissue Distribution</subject><ispartof>Archives of biochemistry and biophysics, 1980, Vol.199 (1), p.76-83</ispartof><rights>1980</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-740cb4d6394b037ff34b3af0d9816723ac028abdbc7193bf2fcffce1f8821c813</citedby><cites>FETCH-LOGICAL-c376t-740cb4d6394b037ff34b3af0d9816723ac028abdbc7193bf2fcffce1f8821c813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0003-9861(80)90258-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6243910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carleer, J.</creatorcontrib><creatorcontrib>Ansay, M.</creatorcontrib><title>Ontogenesis and independent genetic control of the rat adenylate kinase isozymes (EC 2.7.4.3.)</title><title>Archives of biochemistry and biophysics</title><addtitle>Arch Biochem Biophys</addtitle><description>The level of activity of cytoplasmic isozyme II of adenylate kinase (EC 2.7.4.3) appears to be genetically controlled in the rat (
Rattus norvegicus). Adult animals of the Okamoto inbred strain exhibit a ninefold higher erythrocytic activity than the rats of the dilute agouti inbred strain. This difference seems to be due to two codominant autosomal alleles at a same locus. The study of the ontogeny of that enzyme in muscle in the two strains shows that the wellknown postnatal activity increase of that isozyme is reduced in the low activity (dilute agouti) strain. However, the mitochondrial isozyme III activity is not similarly regulated as no difference between the two strains has been observed.</description><subject>Adenylate Kinase - genetics</subject><subject>Adenylate Kinase - metabolism</subject><subject>Animals</subject><subject>Crosses, Genetic</subject><subject>Isoenzymes - genetics</subject><subject>Isoenzymes - metabolism</subject><subject>Liver - enzymology</subject><subject>Muscles - enzymology</subject><subject>Phosphotransferases - metabolism</subject><subject>Rats</subject><subject>Species Specificity</subject><subject>Tissue Distribution</subject><issn>0003-9861</issn><issn>1096-0384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVJSTZJ_0BJQaeSHOyMLK0lXwplSdpCIIc21wpZHiVKvdJG0ha2v752d8mxlxmY92PgIeSCQc2AtdcAwKtOtexSwVUHzVJV7A1ZMOjaCrgSR2Txajkhpzk_AzAm2uaYHLeN4B2DBfl5H0p8xIDZZ2rCQH0YcIPTCIXO9-IttTGUFEcaHS1PSJMp1EyG3WgK0l8-mIzU5_hnt8ZML29WtKllLWpeX52Tt86MGd8d9hl5uL35sfpa3d1_-bb6fFdZLttSSQG2F0PLO9EDl85x0XPjYOgUa2XDjYVGmX7orWQd713jrHMWmVOqYVYxfkY-7ns3Kb5sMRe99tniOJqAcZu1XE4kmJiNYm-0Keac0OlN8muTdpqBnrHqmZmemWkF-h9WPcc-HPq3_RqH19CB46S_3-vORG0ek8_64bvsBFdLOYmf9iJOBH57TDpbj8Hi4BPaoofo___9LyYzjbw</recordid><startdate>1980</startdate><enddate>1980</enddate><creator>Carleer, J.</creator><creator>Ansay, M.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1980</creationdate><title>Ontogenesis and independent genetic control of the rat adenylate kinase isozymes (EC 2.7.4.3.)</title><author>Carleer, J. ; Ansay, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-740cb4d6394b037ff34b3af0d9816723ac028abdbc7193bf2fcffce1f8821c813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Adenylate Kinase - genetics</topic><topic>Adenylate Kinase - metabolism</topic><topic>Animals</topic><topic>Crosses, Genetic</topic><topic>Isoenzymes - genetics</topic><topic>Isoenzymes - metabolism</topic><topic>Liver - enzymology</topic><topic>Muscles - enzymology</topic><topic>Phosphotransferases - metabolism</topic><topic>Rats</topic><topic>Species Specificity</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carleer, J.</creatorcontrib><creatorcontrib>Ansay, M.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of biochemistry and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carleer, J.</au><au>Ansay, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ontogenesis and independent genetic control of the rat adenylate kinase isozymes (EC 2.7.4.3.)</atitle><jtitle>Archives of biochemistry and biophysics</jtitle><addtitle>Arch Biochem Biophys</addtitle><date>1980</date><risdate>1980</risdate><volume>199</volume><issue>1</issue><spage>76</spage><epage>83</epage><pages>76-83</pages><issn>0003-9861</issn><eissn>1096-0384</eissn><abstract>The level of activity of cytoplasmic isozyme II of adenylate kinase (EC 2.7.4.3) appears to be genetically controlled in the rat (
Rattus norvegicus). Adult animals of the Okamoto inbred strain exhibit a ninefold higher erythrocytic activity than the rats of the dilute agouti inbred strain. This difference seems to be due to two codominant autosomal alleles at a same locus. The study of the ontogeny of that enzyme in muscle in the two strains shows that the wellknown postnatal activity increase of that isozyme is reduced in the low activity (dilute agouti) strain. However, the mitochondrial isozyme III activity is not similarly regulated as no difference between the two strains has been observed.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6243910</pmid><doi>10.1016/0003-9861(80)90258-1</doi><tpages>8</tpages></addata></record> |
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| ispartof | Archives of biochemistry and biophysics, 1980, Vol.199 (1), p.76-83 |
| issn | 0003-9861 1096-0384 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adenylate Kinase - genetics Adenylate Kinase - metabolism Animals Crosses, Genetic Isoenzymes - genetics Isoenzymes - metabolism Liver - enzymology Muscles - enzymology Phosphotransferases - metabolism Rats Species Specificity Tissue Distribution |
| title | Ontogenesis and independent genetic control of the rat adenylate kinase isozymes (EC 2.7.4.3.) |
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