Colchicine binding to an oligomer of tubulin

An oligomeric form of tubulin present in microtubule protein prepared from mammalian brain, the 36S double ring containing tau protein, is reported to bind colchicine. Colchicine binds to each individual 6S tubulin subunit in the 36S ring without apparent effect on quarternary structure. The colchic...

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Veröffentlicht in:	Biochemical and biophysical research communications 1980-01, Vol.92 (1), p.183-190
1. Verfasser:	Penningroth, Stephen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Chemistry Colchicine Macromolecular Substances Microtubules - ultrastructure Molecular Weight Protein Binding Swine Tubulin
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creator	Penningroth, Stephen M.
description	An oligomeric form of tubulin present in microtubule protein prepared from mammalian brain, the 36S double ring containing tau protein, is reported to bind colchicine. Colchicine binds to each individual 6S tubulin subunit in the 36S ring without apparent effect on quarternary structure. The colchicine-oligomer complex forms by colchicine binding directly to the tubulin ring; alternatively, complexes formed by colchicine with 6S tubulin subunits associate in the presence of tau protein to form the colchicine-oligomer complex.
doi_str_mv	10.1016/0006-291X(80)91537-5
format	Article
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source	MEDLINE; Elsevier ScienceDirect Journals Complete
subjects	Animals Brain Chemistry Colchicine Macromolecular Substances Microtubules - ultrastructure Molecular Weight Protein Binding Swine Tubulin
title	Colchicine binding to an oligomer of tubulin
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