Protective effect of levamisole and its sulfhydryl metabolite OMPI against cell death induced by glutathione depletion

Levamisole protects cultured cells against auto-oxidative necrosis induced by glutathione depletion. The sulfhydryl metabolite, OMPI, is approximately 100 times more active in this respect. As is the case for vitamin E and synthetic antioxidants, the cell rescue is not due to the inhibition of gluta...

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Veröffentlicht in:	International journal of immunopharmacology 1979, Vol.1 (2), p.93-100
Hauptverfasser:	De Brabander, M., Van Belle, H., Aerts, F., Van De Veire, R., Geuens, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Survival - drug effects Cystine - physiology Fibroblasts Glutathione - physiology Humans Imidazoles - pharmacology Imidazolidines Levamisole - pharmacology Necrosis - physiopathology Vitamin E - pharmacology
Online-Zugang:	Volltext
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